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[ Everything You
19
-

Epidemiology y
Como 19

• Corona viruses are a

large family g
viruses

• Cause illness in animals or humans

humans Common cold to
ranging from
•
In ,
MERS ,
SARS

Most discovered ( 2019

•

recently -
2020 ) CoV causes could -19

Origin : WUHAN ,
Hubei .
China

first case China first India 's 5th Feb

Whelan 7th
in Wuhan 3ft identifies death in first Feb
osenais
case

IMHO 1st Jan 9th goth Named

of Dec fthgan No
alerted Jan
"'D '9
2019
zozo
Jan
Effective
treatment
by
i¥ymo
China admits WHO
declares
threats
knowing Pandemic
before lpubhz
Alarm
( Epicenter )
As Per 3 1st March 2020 In India : In us ;
into #
-

Cases 1251 Cases 164,253

Cases I 785,807
= =

Deaths 32 Deaths =
3,167
Deaths
=

=
37,820
Recovered 102 Recovered =
5,507
Recovered 165,659
=
=

l
,
l

a
i

In
Italy ( Most affected )
-

In
,

China (
-
conspiracy
to
cases =
81,518 Hide ) Cases =
101,739

Deaths =
3,305 Deaths = 11,591
=

Recovered 14,620
Recovered 76,052
=
=
 Causative Novel Coronavirus ( SARs
agent 2)
• :
-

CoV -

Cases ( from
• Source g
Infection
: other
infected )
• Median Incubation Period : 5.1
days ( 2.2 -

11.5
days )
Mode
•
y Transmission :
Droplets ,
Contact 2 Fo mites
•

Age group : All ( mostly so t )

Morphology
club
•

Enveloped ,
carrying petal
or
shaped or crown
like
loner
pep spikes giving appearance g
solar corona .

( 120
)
Large
•
-

160 nm
,

• Helical
symmetry
• Linear , positive sense ss KMA ,

Non
segmented genome
.

Classification
corona viridae

I
1-
Corona Toro virinae
tlirinae

animals
a p y g [ Most infect except Gamma
( coronavirus es )
coronavirus
]
•
Human coronavirus es : 6
recognised coronavirus es to
human
cause
infections
-

add
Now I wi
:D .

I,
 ①
§
Human coronavirus 229 E

② Human coronavirus NL 63

③ Human coronavirus 43

{
OC -

④ Human coronavirus
④
H KUL

coal
③ SARS -

⑥ MERS - CoV

⑨
x
{⑦ Could -

19 (SARS - CoV 2 )
virus

/SARs-w
Dr Carlo Urbani )
• 2003 ,
China ( Kino
physician .

( Discovered in Business man )

•
8098 cases in 29 countries with over 774 deaths
-

• Source Contracted
from
civets
animals
rodents
,
including
monkey , palm ,
.

Then Human to Human

-
IM ERS coil -

middles syndrome
•

pirating Coronavirus

Mortality 304 .

deaths
• Between 2012-2018
,
about 2143 cases ,
750
-

from 27 countries .
 After entering into host cell
•

A
uncoated
virus
particle
I
Genome enters cell
cytoplasm (coronavirus RNA
genome
has

methylated poly adenylate d

' '
5 & a 3 tail
cap
which allows RNA to attach to host cell

Ribosome Translation
for .

Corona virus also have dependent

• RNA RNA
polymerase
In
which allows viral to transcribe into new RNA

host
genome
copies using
cell
machinery .

I
first protein to be made
,

Rd RP in the

µ
stops by stop codon
,

After Rd KP
gene coding ,
translation
Nested Transcript )
(
 LAB
diagnosis
•

Nasopharyngeal swaps
&
Oropharyngeal swaps
•

Specimen
should be collected as soon as
identified .

RTramcn'p¥R in med .

Genes focused are

(N & E ,
Rd RP )

Genes ( Een ) For Bat associated 13

screening any
•

Coronavirus

Rd Rp like Corona virus 2)

•

specific for SARS & SARS

( 2019 -
n coal )
 pharmacological
• Remdesiuir .
Nowadays
Earlier med
} for
=

Favila ":
•
Ebola chloroquine
t
H
inhibitors Oseltamivir
RFA polymerase .

Medicine
• Hard facts about Collie -

Ig

Could
Influenza Ig
-

Median
-
-

2nd 5. Sd
incubation

/
Period

3d 5-6
days
Interval

pqo 0 It 3%
.
.

•
Fraction g severe disease in more in could -19

80% - Mild
157 .
=
Severe ( Supplemental Oz)
Critical ( Ventilation )
54 .
=

Require
to times
mortality
•
more .

Confirmed Case
state )
=

• LAB
diagnosis ( Irrespective g
clinical

Fever Rhino rhea

{Cough
•
-

Diarrhea Ican Ican not be present

sore Throat
•
Sever
Casey 75
year old patient suffering from
#
Cov l D -

19
-

it when 2
stop -
o

consecutive
•
If 2

negative PCR reports

atleast 24 hrs
apart
.
 Prevention
-

Hand
washing ( with soap 3,20 see )
•

•
Alcohol based Hand samite 's er (I 604 .
alcohol )
Avoid
touching face
•
.

• Cover mouth & nose with a tissue when

coughing / sneezing
•

Surgical masks
•

Self Isolation ,
self quarantine
-

( for all ) ( for infected )

• Social
distancing

② Meditates