Republic of the Philippines

ISABELA STATE UNIVERSITY

City of Ilagan Campus

IMMUNOLOGY (BS PSYCH 2)

MODULE 2

IMMUNE CELLS AND ORGANS

 Primary lymphoid organs (thymus & bone marrow) for production of lymphocytes
 Secondary lymphoid organs help antigen to come into contact with lymphocytes expressing
appropriate specific receptors
 Lymphocyte numbers are carefully regulated, and they recirculate
 T cells express CD3, and recognise processed antigen presented by MHC molecules
 B cells express CD19 and CD20, and recognise intact, free antigen
 Important APC are dendritic cells, B cells, and macrophages

1. Name the primary and secondary lymphoid organs and briefly differentiate between their
functions.

Primary lymphoid organs: organs where lymphopoeisis occurs, i.e. where lymphocytes are
produced, including the bone morrow and thymus to produce T and B lymphocytes.

Secondary lymphoid organs: where lymphocytes can interact with antigen and with other
lymphocytes, including spleen, lymph nodes, mucosal associated lymphoid tissues (MALT)
2. Draw simple diagrams to illustrate the structure of the thymus, lymph node, spleen, Peyer’s
patch and indicate the changes that occur after stimulation by antigen.

Primary lymphoid Organs:

Bone Marrow
- Site of haematopoesis, i.e. generation of blood cells
- In an embryo, this happens in amniotic sac
- In foetus, occurs in all bones, liver and spleen. Marrow is also very cellular
- In adults, this occurs mostly in flat bones, vertebrae, Iliac bones, Ribs and the ends of long
limbs

Thymus
- Where maturity of T-cells occurs
- Bi- lobed
- Medulla and cortex regions
- No change during immune response to antigens, continuous development of T cell