Anaphylaxis

Give IMI adrenaline (1:1000) into outer mid-thigh

Less than 5 years (7.5 to 20kg)
150mcg device
5 to 12 years (> 20kg)
300mcg device
Over 12 and adults (>50kg)
300 mcg or 500 mcg devices

Assess if repeat dose required at 5 minutes

If 2-3 doses are required, consider adrenaline infusion
Adrenaline:
no contraindications to adrenaline for anaphylaxis
Adrenaline should not be withheld in anaphylaxis due to concerns regarding drug interactions.

Adrenaline:
- beta blockers: especially non-selective e.g. propranolol (hypertension then bradycardia) [may
need increased dose and/or glucagon]
- cocaine: arrhythmias
- entacapone, linezolid, Mono-amine oxidase inhibitors: inhibits one of adrenaline metabolism
pathways (can increase concentration)
- Tricyclic antidepressants: potentiate adrenaline effects