P-A M-1 L-8 Diabetes Complications

Uncontrolled diabetes mellitus sets in an abnormal state in metabolism in the body. Therefore, all tissues/organs
of the body are in threat of developing complications of diabetes. Long term complications are mediated by
microvascular and macrovascular changes.

• A diabetic is at risk of developing coronary artery disease, stroke, blindness, renal failure, lower limb
amputation etc. many times more than a non-diabetic person.
• Children with uncontrolled diabetes may have problem in growth.
• Pregnancy in women with diabetes threatens both expectant mother and foetus.
• Acute metabolic derangement may lead to life threatening diabetic comas, such as diabetic ketoacidosis
(DKA), hyperosmolar non-ketotic coma (HONK) etc.

Diabetic Complications
Uncontrolled DM is key to
Long term complications Acute metabolic derangement
complication

Uncontrolled DM sets in an Long term complications are Acute metabolic derangement

abnormal state in metabolism and mediated by may lead to life threatening
thereby all tissues/organs of the • microvascular and diabetic comas such as DKA,
body are in threat of developing • macrovascular changes. HONK etc
complications of diabetes.