GLUCONEOGENESIS & GLYCOLYSIS_ REGULATION

HIGH BLOOD GLUCOSE

INSULIN
GLUCOSE
2.7.1.1 GLUCOSE
Endoplasmic Reticulum
3.1.3.9 2.7.1.1
Glucose-6-P Glucose-6-P
GLUCAGON

Fructose-6-P Fructose-2,6- Fructose-6-P

LOW BLOOD GLUCOSE

bis-P
3.1.3.11 2.7.1.11 AMP
ATP AMP
Fructose-1,6-bis-P Fructose-1,6-bis-P
3P-Glyce 4.1.2.13
OL rol
ER
YC 4.1.2.13
GL
Di-OH-acetone-P Di-OH-acetone-P
(Glycerone-P) (Glycerone-P)
GLUCOSE
2 3-P-Glyceraldehyde 2 3-P-Glyceraldehyde

2 1,3-bis-P-Glycerate
2 1,3-bis-P-Glycerate

2 3-P-Glycerate
2 3-P-Glycerate

2 2-P-Glycerate
2 2-P-Glycerate

2 P-enolpyruvate PYRUVATE
2 P-enolpyruvate
4.1.1.32
2 Oxaloacetate 2.7.1.40

LACTATE
2 Malate Aspartate 2 PEP 2PYRUVATE

-OOCCH(OH)CH COO-
2 Aspartate 2 PEP 2PYRUVATE
2Malate

-OOCCOCH COO-
ACETYL-CoA ATP
2 -OOCCOCH COO-
2
2 Oxaloacetate 2 Oxaloacetate
LOW BLOOD GLUCOSE
TCA
CYCLE
Citrate
6.4.1.1
6.4.1.1
2 PYRUVATE 2 Succinyl-CoA 2 PYRUVATE

2 PYRUVATE 2 Succinyl-CoA 2 PYRUVATE

LACTATE GLUCAGON
2 PROPIONATE

2 ALANINE
2 LACTATE
CO
RI CYCLE

LOW BLOOD GLUCOSE

ENZYMES
2.7.1.1 Hexokinase
2.7.1.11 6-Phosphofructokinase
2.7.1.40 Pyruvate kinase
3.1.3.9 Glucose-6-phosphatase
3.1.3.11 Fructose-bis-phosphatase
4.1.1.32 Phosphoenolpyruvate carboxykinase (PEPCK)
6.4.1.1 Pyruvate carboxylase

Designed by Donald Nicholson c 2002 IUBMB