Learning Log Student Name: Cathy lyn Baranda Week Number: 1 Aftor studying thic topic J leaned that (inclade answers to study questionc): 1 What is atholegy? What is hish pathology ? Fathobogy, according te the sey get ‘6 the study of diseases that 's considered b bri ge sence and mediune, Tt ss what happeme + the tisucs Jor ans of the body in the presence of disease, Under pathology ts hi's fe patho- hay, a branch that deals with the brsue changes chovactewishe of disease. Typically, tissues, cells, and celly- lar matwial ave examined iin this field. Z:. Why ts histopathology important ia the diagnosis of A'sease? Asa field, hi'stepathe logy “s smportant ta disease diagne- sis as it affeds a wide vange of fitlds in medicine. It fills in the blanks and identifies the unknown to move forward with the disease treatment and prevention, With the absence of histe paths logy, caving and ‘dent fying diseaces would be extremely arf ficult.3. What are the major events in the bistvy of Pathology ? Whe have vontributed in the development of the fields of tology and hist pathology? > Hippecwates of Cos (460-376 8c) - humeral theory of nature - clear deceriphions of patthalegical features made by bappouahe writers > bristle (364- 322 Bc) = eunders of Ww > Hevephilos (335-290 be) - first figures f pursue anafd as a suence - one of first cautentist® knewn dissect humans > Evasistrahs (304- 150 8c) = seught tb explain symptoms and complaints by refwene to observed morpho legical changes - one of fivst soventistt known f dissed humans Pcornelivs Celsus ( ¥0BC- 38 ao) - "De Re Mediana” prvides the dassic Aehuihon of Inflammation sfill acceoted today * Welae ver 'aflammahmis sunt guatrer vubor ef tumor. cum colore et dole” 26alen ( 124-201 ao) - Wivildissection of animals ard realized their im- portance os the rewavrent neve and anne ry concer-inhaduced the wnugt of bled Iething - deswibed crab- like grmth of cancer -attbukd ft adeli'ng 5th ” of iaflamaton Chse of fanction/ thrbhirg pukahin ) - made “seats of byseases “and “Abrwrmal Tumors” - his influence Ainctd mediure for ww yours, int the Middle Ages > Aetins of Amiola (902-575 aD) - left notoble deseviphions of the cavernema of the uteus, hemorrhoids, condylomata, and fissures avd ules of fhe recim > Avicenna (80- [037 AD) ~ "Canon Medicinae” based on the doctrines of Galen and Avistotic - considered the vest single work in mediaune until the 15th Centur, > Avenrar (1070-1162 AD) - described cancer of es trophogus and the shmath accurately, in addition fo other lesions >Antonio Bemvieni (1443- (502 AO) -“De Abdi Nonnullis ac Mi'randi's Morborum et Sanationum Causis” - with Ill cases, 20 post: mortemsJean Fernel (1491-1558 % 4D) - main work i's “Mediv'na” became o Furnpe standavd - classifies disease into tar: geneval or special - dishvgurshes symphns ard cigns - first individual th sug gest syphilitic origin of some anw sms ? william Harvey C1579 - 1057 40) -"Do Mor Covdis et Sanguin's” (1626) changed medicine and concept of disease causation - prof of blvd cirelahm and the funchim of heart disproved humeral fh ~ sheabfied relationships of ventricular ruphre and left- sided hypertrophy 10 @ patent wtb aortic value sufhi- cen > Marco Auris Severino and Nicolaas Tule (170-1674 AD) - first illustrahone of disease prcesses or athe logic changes > Thea phile Bonet (474) 2 “Sepulchretum sive Anatvmica Prachea” has case desoniphims of autpry reporte ovroraged in anatom=- cal cechons from head fo he2Dutchman Theodore Kerking and Sreven Blankaart (40-170) -“Spialegium Aratymicam " by Ker king -“Aratmica Prochca” by Blankoart > Herman Boerhaave (166s - 1739) - able ® publish well- explained aubpsy cases anol thar relation to the recent medical history of patients > Giovanni Bahsta Morg aqui (100, 1761) -"Adversaria Anatomica” in 1706 ~~ De Sedibus et Causis Moyborum pu Anahmen Sndlag ans “dcoasses Causes of Asease Phroug h anatomical savesthgation - accyo tol that diseases are ovgan-based - beginni of modern mediane >John Hunter L172¢- 1743) - dabbled in experimental pathology ard use of prim hve micas copes - “Treatise on the Blood, Sflammation and Gunshot Wounds and “Venereal Disease” -desubed s'aflammahm as an jnjhal dchaise mechanism and wentually ac a vepevative prrcess > Mathew Baillie (1743) - authored the fist csystemahc textbook of pathahgy enhthe “The Morbid Anatomy of Some of the Most Important farts of the Human Body .> Maric Francois Xavier Bichat (177I- 1¥02) -able Impave the foundahon of the knowledge on Hssuc-based aiseares by saveshgating freshly - execu ted bodies - rdentificd LI olgeases - correlakd the cinical findings ht hictolog y > Gabriel Andal (1197-1976) - antinued Bichals work - published ‘Préas d’ Avatomie Fattolegigue ” with two Volumes Geneval pathology and specal fatheloga) > Thomas tHodgkin (1799-1966) ~ published “On Some Morbid Appeavances of the Absorbent Glande and the Splean” - records of his findings in Poutopries induding cases of 7B . > Richard Bright (1748-1859) - extensive studies on the wnnection of kidney Wsease and oedema ? Thomas Addison (1793 - 1960) - first described perniaims anemia 7 dthamnes Muller ( 1801-1868) - first to use mics cope in ctoing extensive analy ses of diffwent tissues - "Veber den feinen Bauund adie fermen der krankhaf-ten Ceschwulste” Rudolph Virchow (1821-1402) - Die Cellular Perth log ie” as a collection of 20 lectures and his most important work ~ start of a new undewstanding of pathology fom organ- based te ca- based 2 Edwin Klebs (1¥93 - 1419) ~ disavered paraffin embedding wher using a micrs- wpe fo shady cells Citt5em > feecre—ene—Peedirarca laa 1943), Tredrich von Revk ling hau - mastw in inveshgahng bone pathology, published impor tant shdres on thrombosis, embolism, infavcton, otegenc- rahons, heme chrmatosis, adenomyomata of the ubeus, other pathelgic wnditons, and his descr) on of “mulh- ee ple neu fbromat sis” > Isaac and Ferdinand Blum (1¥73) - advocated use of formal dchyde solution 17 cell fixahon > Cdwing Kebs (1978) - found links between bacteria leqy > Julius Cohnheim (1839- 1£&4) - demonstrated origin of pus” came from blood ano not and infechs ohseases hissue edlls> Dorothy Reece and Car] Sternburg (1#a8- la02) - Reco- Skwnberg cell was ditavered - cfescerbed his' bogie deseviphion of the Celle > budwig Asch off (1866-1442) ~ developed wncest of the rehiuls -endcothelral system > Karl Landstuner (16s -1443) - basic for medean blood typing > Wikolat Anistschkev (1¥85 - 1464) - dewibea his Popa thology of the heart and prpesea the role of cholestevol in atheyrsclertsi's > Paul Klemperer (1984-1464) ~ deconbed the concept of “collagen disease a > Albert Coms (1412-1979) - discovered fluorescein labelled antibodies > Georges Kéhler and César Milstain (147s) - htcovered monotonal antibodies > Kary Mullis (1475) - invented PCR technique I would like fh know more about: > Any previonsly rejected ideas or wncepts in pathalegy that wee laty prved fo be true