AJAYAN, et al.

MAJOR INFECTIONS IN NEPHROTIC SYNDROME

WEB TABLE I PREDICTORS OF PERITONITIS ON UNIVARIATE ANALYSIS

Characteristics With peritonitis[n=14] OR (95% CI) P value

Age
< 4 years ( n=35) 3 (21.4)
≥4 years (n=66) 11 (78.6) 2.13 (0.55-8.22) 0.37
Age of onset of Nephrotic syndrome
< 4 years (n=49) 7 (50) 0.93 (0.30-2.89) 0.91
≥4 years (n=52) 7 (50)
Sex
Male (n=53) 6 (42.9)
Female (n=48) 8 (57.1) 1.57 (0.50-4.89) 0.44
Pneumococcal vaccine received
No (n=95) 13 (92.9) 1.26 (0.14-11.68) 0.84
Yes (n=6) 1(7.1 )
Duration of nephrotic syndrome
< 2 years (n=69) 5(35.7)
≥2 years (n=32) 9(64.3) 5.01 (1.52-16.51) 0.005#
Duration of edema before presentation
<2 weeks (n=40) 7 (50) 0.61 (0.20-1.90) 0.39
≥2 weeks (n=61) 7 (50)
Clinical type of nephrotic syndrome
IFRNS (n=21) 5 (35.7) 13.75 (1.49 -126.85) 0.02#
FRNS (n=9) 3 (21.4) 22 (1.95-247.06) 0.01#
SDNS (n=7) 2 (14.3) 17.6 (1.34-230.54) 0.03#
SRNS (n=19) 3 (21.4) 8.25(0.80-85.17) 0.07
1st episode (n=45) 1 (7.1) 1 0.12
Immunosuppressants received
Prednisolone only (n=84) 12 (85.7) 1 0.70
Levamosole with prednisolone(n=6) 2 (14.3) 3 (0.49-18.22) 0.23
Cyclophosphamide with prednisolone(n=3) 0 - 0.99
Cyclosporine with prednisolone(n=8) 0 - 0.99
Severe Ascites
No (n=39) 0 - 0.001#
Yes (n=62) 14 (100)
Past history of spontaneous bacterial peritonitis
No (n=92) 11 (78.6) 3.68 (0.80-16.87) 0.07
Yes (n=9) 3 (21.4)
Serum albumin
< 1.7 g % (n=23) 5 (35.7) 0.47 (0.14-1.58) 0.30
1.7 g% (n=78) 9 (64.3)
Serum cholesterol
< 400mg/dL (n=49) 2 (14.3)
≥400 mg/dL (n=52) 12 (85.7) 7.05 (1.49-33.39) 0.006#
Serum creatinine (mg/dL)
< 1 (n=83) 13 (92.9)
≥1 (n=18) 1 (7.1) 0.32 (0.04-2.59) 0.45
Spot urine protein: creatinine ratio
≥3 (n=11) 0
< 3 (n=90) 14 (100) 1.18 (1.08-1.29) 0.35
GFR (mL/m2/min)
≥60(n=31) 3 (21.4)
< 60(n=70) 11 (78.6) 1.74 (0.45-6.74) 0.42
Genital edema
No (n=65) 7 (50)
Yes (n=36) 7(50) 2 (0.64-6.24) 0.23
# p value significant

INDIAN PEDIATRICS VOLUME 50__AUGUST 15, 2013