| Advanced Subsidiary nh 1: Lifestyle, Transport, Genes and Health Paper Reference 6BI01/01 }- Instructions © Use black ink or ball-point pen. © Fill in the boxes at the top of this page with your name, centre number and candidate number. @ Answer all questions. © Answer the questions in the spaces provided — there may be more space than you need. Information © The total mark for this paper is 80. © The marks for each question are shown in brackets use this as a guide as to how much time to spend on each question. © Questions labelled with an asterisk (*) are ones where the quality of your written communication will be assessed you should take particular care on these’ questions with your spelling, punctuation and grammar, as welll as the clarit ty of expression, © Candidates may use a calculator. Advice © Read each question carefully before you start to answer it. © Keep an eye onthe time. © Try to answer every question. © Check your answers if you have time at the end. ssesoa IIIT NO Eder Lad, one N35 8 A012 Il ccercat zs ‘advancing learning, changing lives —— — o nny Scanned with CamScannerind about our mind a i an | change Ye ih a cross . an ae tion Answer ALL a4? a jna box" ne’ Fe eset eu Some questions must be answered witha «705 nar answer, puta line through the box &4 ifyou wel wans! of Jes. or role ecu! ture ical MO tru! ; jologic?' ag the 1 The questions below refer to someimportant Tr Gasribe Place a cross (pg) in the most appropriat a) these biological molecules. (a\\Disaccharides dan be split by BLA hydrolysis of glycosidic bonds \ OB condensation of glycosidic bonds 9 FC hydrolysis of ester bonds . RTD condensation of ester bonds a) Staci (bYAmyloseis an example of a CA monosaccharide CB disaccharide LZ A cote QD trisaccharide | (© The role ofstarchi$ to a) G A beasource of energy to plants ~ EB store energy in all living organis XI sGreeneigy in plants Gob store energy in animals insrefolymeis of amino acids joined by peptide bonds formed between rnD (1) BA Rogrtoups © B Rgroup and the amino group 1 € Rgroup and the carboxyl group (p carboxyl group and the amino group ® B® Scanned with CamScanner(e) The three-dimensional structure@f a protein held together by ro) CIA peptide, hydrogen and ionic bonds [1B hydrogen, ester and ionic bonds (JC disulphide bridges and ester bonds _—” po disulphide bridges, hydrogen and ionic bonds fe wee (f) DNA consists ofmononucleotides joined together by bonds between - 7 a OA two pentose sugars ¥ | av (Bone ribose sugar and one phosphate group PKC one deoxyribose sugar and one phosphate group ey neon eens CD two phosphate groups n8' so (g) Water is described as a dipolar molecule because it has a RA “postive charge byei hydrog eDyend andar 1B pesitvély,charged hydrogen end and a positively charged oxygen end =p enargee nyeoser 1 € negatively charged hydrogen end and a negatively charged oxygen end 1 D negatively charged hydrogen end and a positively charged oxygen end (Total for Question 1 = 7 marks) Scanned with CamScanner asod vessel, jor lete peottandil mds to come i the he gor 2 (a) Read through the following passage about ite WO" a then write on the dotted fines the most APP! the passage. os a dl : upper 15, tO The may consists of four chamb ls ventricles: Neus and two lower chambers called the footer. way from 7 The. Verar..Cate. carries oxygenated blood 2 _carties | ‘ the pulmonary ~ Ventrcle tothe cells of the body andthe PINOT” returns deoxygenated A deoxygenated blood to the lungs. The ast blood back to the heart from the body. (b) The diagram below shows the structure of the heart: Suggest which stage of the cardiac cycle is shown in the diagram and give a ay peal tae reason for your answer, dbo shote, | a Rince bth. PV NaWWe3 anc, : ee nc fitted..vith. Bloods & Benilunan, vale, CM redanasy. YAW. Open? CAGKES Lo a ee Prredent. Boo om eloning (Total for Que: Crop ventricles Ko wk stion2 = 7 marks) LNW AAA AMHANA HAs Scanned with CamScanner[_ he fluid mosaic model desc! ibes the structure and pr i . 3 The hows the structure of a cell membr a ee {@) The diagram below 5} Proteins Proteins eal : a Name the molecule labelled A and describe its fracture. J ae dx name ..... Peet eotaR. phere Lips d fapbophobce ho one onientend foesanrd> SE es % Kybraplitic laals..0re ape 22M. —foosandr, pater eavinnnent | ohich. da vane, (ued rn _ Structure paspele (head) 1 Loo Fatty ach Wet ed Scanned with CamScanneri) Explain how th cell membrane. 2H plucoze WH cacti ort and (b) Some proteins in the cell membrane are involved in active transP facilitatéd diffusion. Describe the role of proteins in these mechanisms. r cell transport cilitated eae Re 7x4, _.Channek. &. Cag Prete + Chonnet protein Car Ptr Kon rot poe Gen cmc gourkert Scanned with CamScannersingle a abber proteins (0 In an investiga “J tion into the properties of the cell membrane, the proteins in the membranes of two cells, A and B, were stained using different dyes. The proteins of one cell were stained green and the proteins of the other cell were stained red. The cells were then fused (merged together) to form a single cell. The diagram below shows the distribution of the proteins in the cell membranes before and after fusion. Red-stained proteins Green-stained proteins Cells before fusion o” CellA Cell B C) (i) Describe the distribution of the proteins in this single cell after fusion. sustOn. gle cell er fusion (2) Vi Farion inhemeted..mone'. fron... Goll. A SETI, fran B Single, Cale, _Cortain’y $08... ned - Brainod PID... tS Iden shat. _prokein wel? }e «Blea, bake DOE type Js ites (i). Describe how the fesuliDof thinvestigation can be explained by the fluid mosaic model. ~~ ———s 2) uaick: ‘ {Total for Question 3 = 13 marks) Scanned with CamScanneree 4 Cocai ESERINC Use increases thy Cocaine a vs mets the lves of & Neer attack 1s, including and factor and fines ee lood component in Blood cloting 5S" PPA Bbrinocen, Tees nts are involved ©) Then ogem ie 1a orm en? and for {brinogen is 150 erage ilebrand foctors 5010 150 ™9 Fe“ ream concenanemteas secannal cocaine use on the sen concentration of von Willebrand fectar ad firinogen me BIooS & z a & — 7 es Sis Be zs § = 2 20-85 sues Frequent cocaine use [Ey cxcasionat cocaine use (i) Describe the effects of frequent and occasional cocaine use on the mean concentrations of von Willebrand factor and fibrinogen in the blood. Ene THE Few 2 pos Bea endo 22K... OCC aaéonad, sn OL GAD CM LBR fn e sane Hem tnoian...concentnation..04..dibriinagare..daieciee.L0 ‘S., pencn wn lopaned Lo. Nore. wile brand... } hear conc of Non wilthrand bo Ribsinogen Ancrecre by 15 mg pew ce 8. tne of Coedme Cotaine | : Companed ty occanionol = : we A Cocang Scanned with CamScanner(i) Using the information ivan, explain wl Conchsionscanohbe made about _ the Hact ‘of occasional cacaing use on the concentrations of these blood = components. a oe eee ti he he hate tobe thrcone ae Cammebietioin _ Serene, Bince.... 0Ccarionet..022... Droant, batt, Arabs 7 hote...mche..... Be... AE er... Coane, 2. taed, Tngfonioatson 42.026 Clea encigh, ¥(b) The diagram below shows two functions of von Willebrand factor: ~~ = = Platelet Platelet Platelets stick together er, Lh Endothelial Platelet cell ee Platelets stick to endothelial cells lining blood vessels } — vonWillebrand factor Using the information in this ) mom : (1) bors, eo os : a uggest why this study had to “attest “es er of years, (1) Bin 9G... dpeephe.... Charhe diols AR Lifene, ler —&.... pane sed badly... - CVD J ] hoki : nnahete de Regor Scanned with CamScannerNeo oT 7 {d) Using the data in the table, what is the evidence that drug $ is safe for people to * take? es : — (2) Tuleing s HANhZ Beez, Dawg Shar foerer feath + cp #2 x matte Nate Compared lo faking the... placebo. = i ith (€) (Calculate how man people given the placebo had CvD. compared wi thoseigivendugs “= ) each anoup 10 cooppe digs Fraction = Peputation nabe drug 5 = Fo 092 =) 1444 4 Sie = yor ioe — pag ~ oot % =o4F Qo Answer (ii) Explain why drug $ could be a potential statin. 7 Natsna..bomne, & LovBre M8k...o7 deukhe Crh & phnoke Compare k fo place. Bo CDS AES (Total for Question 7 = 11 marks) Q 94 211.5 | W8- 6.423] faend led @ = i. 3.1 x199 =319 | Scanned with CamScanner(a group of rapidly-dividing oS Sol of can ad to e production © umoUrs. e types ancer le dito th ducti tl nN ‘ = er cells). : ‘ cane maar-diseases, including cancer. ial to cure 2 per of but ; ene horapy ps the Poe relies on animal models of diseases. A present, research into gene uced in two groups of rats. tumours were ind d the other group of rats acted as a a) {none investigation, brain : n gene therapy an One group of rats was give control. The photographs below show the appearance ofatumour in the brain of a control ratandina rat given gene therapy. Both photographs have the same magnification. Brain of rat receiving gene therapy a. Brain of control rat Tumour Magnification x10 The graph belo w sh two groups, lows the percentage survival after treat ‘Ment of the rats ii in the & = 8 22 ag ae cs g 5 Control o @ 0 FELCH HH t 0 10 20 ct Time aft 30 Sr treatment / days 40 Scanned with CamScannerUsing the information shown in th, effects of gene therapy on these rae Potographs and in the graph, describe the (3) (b) Cancer Can cause a lot of pain. Pain can be reduced by a chemical called endorphin that is made by cells in the brain and spinal cord. Endorphin reduces the activity of neurones that carry impulses from pain receptors. Gene therapy has been used in rats to increase the tolerance to pain. Viruses, containing a gene coding for endorphin, were developed. These viruses were injected into the spinal cords of a group of rats. The level of tolerance to pain was tested in these rats and in the rats in a control group. (i) Describe the role of the viruses in this investigation. (2) (ii) Suggest why the injection was made into the spinal cord. (1) QUESTION 8 CONTINUES ON THE NEXT PAGE Scanned with CamScannerLevel ' of tolerance to pain / arbitrary uni 20 w ° {iv) The results of thi investigation are show (i) sugges! | f inthe gr@pP below. { Faas ° z Time after treatment / months 1 ‘olerance to pain in Using the information in the graph, compare the levels of ti (3) the rats given gene therapy with the control group. (Total for Question 8 = 10 marks) TOTAL FOR PAPE ll nett W 80 MARKS Scanned with CamScanner