Carl Philipp Emanuel Bach composed a trio sonata in C
minor known as Sanguineus et Melancholicus (Wq 161/1). In the 20th century, Carl Nielsen's Symphony No. 2 (Op.16) is subtitled "The Four Temperaments", each of the four movements being inspired by a sketch of a particular temperament.[22] Paul Hindemith's Theme and Four Variations for string orchestra and piano is also known as The Four Temperaments: although originally conceived as a ballet for Léonide Massine,[23][24] the score was ultimately completed as a commission for George Balanchine, who subsequently choreographed it as a neoclassical ballet, using the theory of the temperaments as a point of departure.[25][26]: 253 The 19th century French author Émile Zola used the four temperaments as a basis for his novel Thérèse Raquin.[27]