Eugomem6pancxu cuctem ape 080) je camo Aeo oBor cnoxeHor w AMHAMMUHOT cHCTeMa YHYTpaUtbMx MeMGpana renuje, koje 30BeMO erAoMeMBpancKn cucTem. Mopen jenposor oBoja, wmHe ra jouw 4 Suaonnasmaru4H peruiynym, Tonyujes anapar, nvsos0mM, amin M GpojHe MewGpaHcKe Kecuue, TKS. TpaHCnoptHe Besukyne. MemOpane exgonnasmatnsnor cvcTema cy Beoma quHammuHe. Y HeKMma Of THX OpraHena ce curTeTMuy npoTenku, a y apyrmma nunugu, wwe came mewGpaHe pacty. MehyTwm, npoTewHi MW nunngN He octaly Ty rae cy cuHTeTHcaHH HM yrpaljenn y AB0cnoj, Beh ce GouHMM kperibem ynyhyly ka apyram jenosuma exqomemGpatcxar cucrema. Yak 4 TaMo fae Ce MemOpane pasnmumtux genona EC He Hacraemsajy jenta Ha Apyry, wamelyy Hx nocTojn ecbuKacan Haun 3a cnarbe m McnopyKy, KaKO caMor MaTepujana MeMOpaHe, Tako W YHYTpaultber canpyxaja, Tks. BesMKyNapHM TpaHCnopT. Np exounrosu, sesuKyna Ha nnasma-memOpaxn HacTaje npBo kao ynerHyhe ka yHyTpa Tj. ka UwTonnasmn. Kaga ce oneojn og membpaxe u yije y ynTonnasmy, yHehe Ae0 cnonbauiber Pacteopa, Kojm he Tana Gurn canpxaj Hope BesnKyne. AKO je BesuKyna Mana Mi tome Ce yHocn camo TeuHocT, pe je 0 nuHo\ynTosH, AKo Renwja, Hnp. ame6a unn neyKouMT, enao\nTosOM yanaun Behy, Yepcry YecTuuy, npM Yemy je OGrpnu wspawTajaMa YWATONNasMe (naxvum Hoxnyama, nceynonopujama), roBopumo o darounTosn.pw KoMe ce BeamKyna cnaja ca Erooyyrosa je npoyec cynporan @HnOUNTOs, a. menSpana nocraje nnaama-memOparom, Weer canpxaj ua6auyje y earennicxn npocTop, ‘feo nnasma-mem6pane, CrcTem nosesarix MeMOpaHcKnx KeCHYa W YeeNMUA, Koje ce HacTaBrealy jeaHe Ha APyre ‘ann enjonnasmarmunu peTuKynym. Y MHOTAM eyKapnoTcAM Tennjama, HapoxMro OHMM koje waajy wMreHaMBHy cMHTeTcKy aKTHBHocT, EP moxe saysMmaTn BenmKy 2anpeMMny. Yaya nospwina ierosx MeMGpaHa YecTO sMIUeCTpyKO npeBasnnasn NOBpUMHy cnomawiee nnasma-membpane. EP ce HacTasmea Ha jenpoe OBO) # YenoM CBojOM RospumHoM wma jacHo AedMHNCAHe cTpaHe-jenHy npeMa ceojoj YHYTPALLHLOCTH, TS. nymeny, " cnorauiby Koja je orpeHyTa ynTcTony. MlymeH WMHM jenHHCTBeHH NpoCTOP Ca epavykneapHom \MCTepHOM. Tpema oGniny m ynosn, EP ce AenM Ha: xpanaeM mann panynucann (rpanynapHu) marea EP Tpanynucann EP je y o6nury nosesanux nmochaTax mem6paHcirx Keca m ca cBcje urronnasmarcxe crpave Ma BesaHe pyGosome (s60r Kojux uarnena xpanaso Ha ‘eneKrpoucKom mnkpocxony). Ha Tum pH6osomnua ce ogenja nonmmepysalmia npoTenta Kojn cy HaMerenn fa Gyay Anh MewBpancen nporenti, Aa Gyny wcnpyYeHM HeKo] oPpraHenW wn wanyeHn y cnomaultby cpenMHy npexo nnasma-memOpane. Cea TpM Tuna npoTeMHa Jou Ty y rPEP, poGnjajy xparke Hins08e onvrocaxapnga-nocrajy rmmxonpoTenna. THMe uM Ce Meiea ynora, ann ce w oGenexasaly Kaxo Gn y BesuKynapHoM TpaHcnopry Gann yomepenn xa onrospajyhnm onpenmurruma nyTem TpaHcnoprHMx BesnKyna Koje ce anBajaly of EP: UHM Towne nonMMepyeauja aMMHOKUCEnMHa, CaM NoNeTaK TaxBHX nonunermana je cunMan fia CO PwG030M saKawn 3a ocean npoteuH y MemOpaHn rpEP. Y saswcHoc™m oA npmpone AMmHOKyCennHa Koje creme, HacTaiyha nonvnentaa uma ABe Moryhe cyAbHHe: 41)aKo ce cmersyiy Hi20BK HenONapHAX ca NonapHM AMAHOKACENHHaMa, NonMneNTMA Ce, oamax no wanacky wa enue cyGjenMMuye pHGo20Ma, CKyMaBa y Camo) MeMOPaHH, rpanehn memOparickn npotent, 2)axo je npamapHa crpykrypa nonwnentwaa TaKea fa ce ckynvasa y TPORMMEHSMOHANMH COGnin« suja je cnomaunbocT xypporbanta, oH Nporiasn Kpos MeMOpaHy W cKmynaBa Ce Y nymeny EP. Trani EP je y oGnuny mpexe nonesaHnx yeeunua W Hema puOo20Ma ca ysTonnasMarcKe ‘crpane. Vinak, iseroe MemBpave m nyMeH ce Hacrasreajy Ha MempaHe w nymeH PPEP. Ynore mEP cy cnresa nunwga, ykrbyyyiyhn w crepouge, ” moaMdnKaunja npoTenia ‘cunterucanux y rpEP. Mopea Tora, y MEP ce o6aema n xemnjcxa womeHa Maroux Monexyna, YHETAX v3 OKONHHe, Koja Gx Mave Morn GHTH ToKcHUHM 3a hennjy (necTHAMAH exon). Kon xaBoTutea ce muvorex paarpayle y MEP. Tonyujes anapar je cnctem nreociatax memGpancnnx Keca, x3. caxyna, Koje cy HacnaraHe jenna Ha apyry, nonyr Tareupa. 3a pasnmxy on xeca EP-a, caxyne Fonynjesor anapara ce nanopesyjy jena Ha apyry, Beh cy oppojeHe, Ova Koja je HajGnwxa EP, y creapn wacraje cnajarsem memGpancxnx (rpancnopTHnx) BeanKyna xoje ce oneajaly on EP. Ta crpana Tonyujesor anapara ostavasa ce Kao cis-crpana. HacTankom HoBHX caKyna, nocTojehe ce onaxo nomepaly npema cynpaTHoj cTpaHin, o6y4HO Gniwo) nnasMa-MeMOpann, Koja Ce osHavaea ca trans-crpana. Ha nyty of cis Ao trans crpave, npoTenHn nuniaM, KAKO MemOpancen, Tako M OHM y MyMeHY Caxyna, RoBujajy Apyrasmje onmrocaxapanne omnoneTe. Osaj npoyec cnyxn ia oGenexs nporenre. Onn ce TaKohe # coprupaiy, Kako 6 ce KacHwje ynytunn Ha ogrosapajyha oppeamusra. TaKo oOenemweHn ¥ copTupaH, onauHo ce ogeajajy on cakyne Ha trans- CTPaHH, Kao AeO CeKpeTOPHNX BesMKyna. OHE HacTasmeajy nyt Ha ocHoay oBenexja Koje cy AoGune Aa Gu npoTenHn Ronn AO MecTa Ha ome fe Gum wcKopnuheHu: Kao HOBH feo MeMBpane, eum Koja je noTpeOaH y HeKOM6uoxemujcx caro prensa an Y mse remorse TaMo nowosKnn cao) ae: Bpahajy ce ua crapyivx ka HOBMjMM bit cate Tenwja, jena on saxnux genosa EC cy m mH3030MM, ei eo pences. noes ae ee yHeTax eHqounTosom, TaKo Aospajanux opraHen’ as : ia ‘je. On nojegunux memGparicknx BesuKyna Koje Ce onpajajy OA ae napara, Hacraiy npawaprn nisosomn, Onn y ce6n wMajy pasate XMAPOTMTS eHOMMe, KojM xwponwsoMm pasnaxy paannumTe rpyne OpraHcKux jenMtberea (nporemne, Runae, yrrsere xnapare, HyKnenHcKe nacennve). Onramanna pH Tux exsnma Je O° 2, wo je Bpno kuceno, a Banco je us aga pasnora. Mpeo, H’ joun yuecrayiy ¥ exaHuamy CHSMMCKe Peaxuyyje, na je GuTHo qa weuxosa KOHYeHTpaynja Syne BUCOKA (TKS. kcena xmaponn3a). Dpyro, ao exavmm nnaosoma, Hnp. nyyatsem Herose membpane, Aocnely ¥ UATONTaSMy, tah Re ce y Heytpanvioj cpeamnn, me je HuxoBa xugponnTmuKa aKTMBHOCT saHeMapreMeo mana, 360r Tora y caojoj em@parin umajy Opojre acrusve TpaxcnopTepe-TyMne 33 Hut jove. JeawHo ur npAMapHMM musosoMMMa HeocTaje cy cyncTpaTH pasrPantee- Houx he ROT chajawen ca enjoyWTosHoM sesmynom (Tra. cparosoMoM), YHMe HACTaI® CekyHpapHu nuso30m, a Yeo npoyjec pasrpaptse 30BeMO xerepocparvja.y cny4aly ayrocbarvje, ceKyHgapii mg020M HacTaje cnajaikem npmMapHor ¢ MeMOpaHCKOM KecvHOM y upTonnasmu, Koja je npeTxomHo o6asuna HeKy AoTpajany opraneny. MpovsBonn xMApOnNse, Ce AKTABHHM TpaHcnoprom npeHioce y uMTONNasMy, (me ce HCKOpMLInaBaly. Ykonnxo npn pasnaraisy ocTaly HeKe He pasnomeHe ecruue, OHE Ce ers0yHTOsOM WS6aLIyly Ba henvije, Kao Tks. npeocrano oAHOcHO pesyayanto Teno.