Masoud Movahedi, Ali Akbar Amirzargar, Rasoul Nasiri, Armin Hirbod-Mobarakeh, Elham

Farhadi, Marzieh Tavakol, Nasrin Behniafard, Bita Ansaripour, Batoul Moradi, Ahad
Zare, Nima Rezaei,
Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with
clinical phenotypes,
American Journal of Otolaryngology,
Volume 34, Issue 6,
2013,
Pages 676-681,
ISSN 0196-0709,
https://doi.org/10.1016/j.amjoto.2013.05.002.
(https://www.sciencedirect.com/science/article/pii/S0196070913001245)
Abstract: Background
Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. T-helper
(Th)2 cytokines seems to have major roles behind the scene of unpleasant symptoms
resulted from AR. Expression of interleukin (IL)-4 and its receptor could be
affected by single nucleotide polymorphisms (SNPs). This study assessed the effect
of 4 genetic variants within genes of IL-4 and IL-4R in AR.
Methods
Allele frequencies of one IL-4R variant (rs1801275) and three SNPs of IL-4
(rs2243248, rs2243250, and rs2070874) were investigated in 98 patients with AR,
compared to a group of controls, using PCR sequence-specific-primers (PCR-SSP)
method.
Results
Homozygosity for the C allele of rs2243250 in IL-4 was significantly
overrepresented in the patient group. CC genotype in rs2070874 significantly was
correlated with AR. GG/CC/CC and TT/TT/TT (rs2243248, rs2243250, and rs2070874)
haplotypes in the IL-4 gene had a significant negative correlation with AR.
Conclusion
SNPs in IL-4 are associated with AR and could change the clinical picture of the
disease in patients.