You are on page 1of 10



VITAE, REVISTA DE LA FACULTAD DE QUÍMICA FARMACÉUTICA


Volumen 8, Números 1 y 2, 2001
Universidad de Antioquia



    



 
         
   
   
 

   !"! !


#
    
!   !     
   


 $ % &"' ( ! )% * &#' +  ! &$
%   &
 
 !     '  !    & ( 
 
 )
 '
) 
  & )     
(   

*
   
 
  & 
 &

  + ) '  )

       

!

,   % - 

 


   
       
       
   


    
    
    


     
         
       ! "#  

 
   $  
      

   
 

  !        $    !  
"     %  
!      
        
 $  

&'( )*+,   


  
) *

    
  
)  
) 

   


'


) . 
!  )   
   
) '
 /  0

'-.'/

'  0   1             ! 


       2 34 52 6357 !  $
  $   5 657              

, -"( !  !."!& !  !%  !."!& !/ !$(& + !0 0 1  !%$!&
!"0 0 -"( !  !."!& 200 0 3"&  4 52 6 &&!
7 -"( !  !."!& !  !%  !."!& +  0 1  !%$!& !"0 0 -"( /
!  !."!& 200 0 3"&
8 -"( !  !."!& !  0"!!%  !."!  1 00&0 0! & + " 0 1
 !%$!& !"0 0 -"( !  !."!& 200 0 3"&
8 9 :'

        !  0        


  1      1 !    
;  $0 $    <         
  2               $4  
   0 !   %0      0   
     =$   <   2  0
             !  $

; ;9', 


   
) *&  1&
   
) 1 '

  2
 )


 !  ) 
         
 )  
   
 )   3'
 0


/*+- :>/ !   0 0  !00
020" < !!2 0 0   ! /
' -"( !  !."! 9-:; <  !/  0 !  

   
    
%$  $! 0  ! 9:=  !"   1!! "0 3"
!  ' 00 5"(0!' .! <   !2 " 0 %  0 "0&
   5 %  0  0! /   *'  0 !"  ! 0
 9>:  "  0!/3"?$! !     0  " 1!! 0 /
+"!% ! 0 5!! +& " /  $ 0 !00  "04 $ 
%  !!*0  +!  !      2 ! ?
" 2! + !."! ! $ <        $  ! ?
 0!% 0 0!  9 >: !  &  . 3"  ! 0 "!%
!%  !" <@  " "0& 0 !"' >( 0    +
 !"  + !% 0 -'  2 0  "0&  +!  0  0"!!%
!   3"    "!"'   0 5    0 
0  < 0 +"! ! $*!%'  !$( <  00
!0 !  + ! !!  !'    0   +!"0
 02   ."!& 0 -"( !  !."! 0 ('  !" 
 $'  00 !0 " !200 ! 5' " ! 0 2/
!  !! 0  + 0  "04 !  0 3" 2 00 $" < "0'
-' .0!' 0%$' .0! 2/  ! "!! < 00A !/
 < '  !1! 0 "200   3" 0   "  !  /
 !0  ."!'   " 0 5 0 $ !0' 00  $! !/
 >  "  .0!/3"?$! <   % !  " + 3" !0!  %/
 !% 0  "0& -" 5* $" 0 ' "! 2! ! !' 3" 03"
 + !  00 0 00  $1+!' (0! < !+ !/
$  ""'  !" 0 2 ! 2/ 0 ! 0!  !' $.! <
 .! < ' !  + 0 +! ! ! 0 $  $ 0 /
<  %   '   .   "0 9: < 0  0 !B 1!' 2/
+  <  " &  $"  0 $0   2 0 5"!' 3"00'

;  < 7,7 0 ,CC=& $"  +% 0 -"( !  !."!' !  1 0  "0' !  + 0 $ <
2$"0  0! 3"   !% 0 3"   $" !00 < $"00   0! ' ! .!'
! + !."! !   0"! " < 0 1 "  0 "0 !0 !  !  0 0 
-"( !  !."!D
= < ;E= 0 ,CCE& $   +% 0 .!$  $! 0  !' !  1 0  "0& +. 0
$1' ,CCE&


     
 @

000 < 5  3"&   / "  !+ !% 0 ! .  /
 02$  "" 0 

   0  0 2"!% +1 ! ."!' 0  !/
00'   0 0 "   0 +/
  '  52 0  (!"  !%' 0 !  0!% 0  /
+! + !% 1! < 0! $" +!!% 0 "" < 0 "0  "0& 
!0  $ < .! 0  ! +/ 0! ,EC, 0 ,CC; $   < FI 0
!."!   ! 0  !%  / ,CC8  !"    0  "0 < /
!."!' 0  +  3"   !"  / 2!% 0  + 00&
! "   3" !"!  !" /
  !00 0    !0' ; *$%0 .   
" 0 3" " 2! 1  / 6*. A@87& +    1! <
2$"0   "0 0  !%&  !5" 0 00 0   0 $(
0 !004  +"!" 9"!"' /
!0 ' !' !": <  !!
/' '+'/'  1! 9 '  : 
$"  !+* "+!  3"  /
  '  !"" 0  !00 <  0"!  2! +! 0 0 !0/
!!% !2'   $  0  ! 0 !00   "  3"  0/
+ 0  "0   ! *'  0&  !  +"!% 0  0 /
3"  0+!"0 " 0 < 2"!%&  !%' 3" 0  <   1!! 
 $   (   00   0 (! 0  !00E&
$ !"       
  0 )( 0 00F   "/ +   A@CD   E8    A@@F
! 0 0 2! 0 "0'    $    !  E  A@FE !   !
! 4 EAE  A@@D  1     0
  35&  5 0 .  $   5/
; ; ! ABB  A@@&     !! 0 -   !0 ! " 0!'
"!" "   $ 0 )/ 0' $! < !&   /
( 0 00 0   ) 0 $"/  (!" 0  0! 0 0 #1 /
00 !  "0 9):' !"< 52   0 !!%D'  $"  5!! 0 0/
$"  2! ?! ! 0 "0 < ! +%'  !"  0+   $"
!  !0! 0 !! 0 0  / .    (!" !4 # " +/
!%  2!  " 0+ 2 0  0 1 0  "0' !"< + !% "/
!%G&  < +" $ 0   0/ 2  !!1  5! !200
! 7,G; 0 ,CCF'  0 0 !"  / +   0' !%' /
$   '
'   0 0! 0"!!%' ! < 2$! 0  ! <
$0 < '     !% 0 / 0"! !0   (!"  
  0 00 0 2!  !."!' !/ 0  < 7,7 0 ,CC= <'   !200 -"(/
!0 !  3" !' 0H < 5/ !  !."! 3" !0   "0 /
!"!% 0 "    5  0  020" < !!2D&  (!" 8' C < ,I 0/
!00 0  + !% < 0"!!%   " +  !! 0 -"( !  !."!'
!! 0  0! &   . !%  !."!' 0"!  !."/

F   0 $( 0 !00  2! + !."!' !0  0 + ('  !(!' !"$(' $(
< &
G ?! 0  & < ,II 0 ,CC8' (!" ,=7&
E ' ,CEG&  0 +  .!! E78' 87I
+ & )' &,=  7I&
CB 9 :'

!' !   !."!' /  "  5"(0! 3" 0  !2
  !."!' !% 0 0/  2 !   2! 0 !%
! '  .!' !%  !."/  "0 &
! !   0"! " 
" 
  "0&  0   0 2! 0 !%
 "0 '  )  "   /
 $ /  34 5? $  !   0 !0
2   6 /357&   $/ " 0    3" !"< 0! /
  ! 0  3"( ! + !."! J  &  -   5  3" 0" 
  !" . 0 !/' 3". 0/ ! 0 !%   !' 0 
 H " !200    !/ !!   !  3"  !/
&  $    +"!% 0  / 0' 00  %! 0 " !00 9 0/
*  !00 !  +' 0 !"0 !  < +:' !"< 0! 0 /
  !0   <&  (!" F 0    !!(! 0 !00 %$! !/
" 0 - >   ! 0 (+!' $00' !!00' !"00'
 2 $  0 "0 3"  " !' "00' +!!' +!!%
 (" !(+!' 2$2 < !2 0 ""' 2 5"(0! < .!&  "/
 +  !2 0 0  !4 0!' !% 0  ! 500 <   ! 0
0!2 0 ! "2' 0 ! +1 !   + !'    
"0 < 0 ! 0"!2' 0  / 0 !! "0 !   
' !$' !+! < ' !  !!% <   0!%'   /
+ 0 2  !!%   + !%   0 "* !  "  0 "0' /
0 + - $' !0   !/ 0  !" 3"'  " !!  !/
00 < ! 0 0& 2    0   !"  < "/
0 0"! + 00 9$:& " /

 !% 0 2!  !."!
0!!% < " 0  !0 !  2/
 
' &   - 00  2!
! !(+! + !0 $! 3" 2/
 !."! 0 2! 0 !% "0 0
0! " ! $.! < 0 2"/
$"0' ! < !" 2 0 ! 500'
!  !!% !00 0  !
!    0 2! 0   2 
!  - < 0 1 + 0  "0 
  0   0 )( 0 /
+!  ""  5 2! 0 /
00 9): 0   0 " ' 0 
!%  "0' !00  +  $
 !% 0  "0 <  2!% 0 
0+ ! ."!&
+! 0 $ !0 !  " 0 
0!   "  .0!/3"?$!
0 0 !% "  <  ' 00 "    4 
$  3"   $  !&  0     $     
! $"00' +!!' +!200 <
5 !  "" '  ! / 
"!" < 0 !!  2!/
 0  !%  !."!&  52 0    0 $( 0 !00 0 " /
  0 )( 0 00 0 2! 2!  !."!  5  0 0
 !."! 9):  $" !0!/ "0 0 ""  0 +!   "* 0 
 0 2 %  3"   / < 78 0 ,CE, < " 0! $  88EI
< < !  3" 0 "0  0 0   H' < 0 <! 0 < ,=F 0 !/
 1>  0 +! !   $  " 7C 0 ,CCC 0 0'  !" !0/
!'  !" 0"01  0  /    ! 0  00 !2'


     
 CA

 < .! !!" < >!!" 0  0 ! !(!&   .0! 
 + 0  "0' !  ! < !' !   -    0/
!  "! 0 0 "0
' ' !  + 0 <  /
 < ' !"<     !   $!% 0 0  0$! < !"00C&
!> 0 5!! + 0 - < 0
& G  2    &  /
   5""0!'    !$/
;     &  !%0$ !2 0 0  >'   ! !
!   +"0    ! <    (!" 78;, 0 !%0$ !2& 
  00 +   / $!' H < !   !0
!% 0 0H < 5"!&  < 78 0 ,CE, < !  " 0  % 0 0H !
" 0! $  88EI 0   H' !"0  2  ! 0 " /
!0  00 2' .! <  00 0 !"!%&  2! + !."!
!!" < >!!" 0 " +/ !   0 2! 0 !%  /
 0  "0 < 0  "!%' !"<   "0 0( !"   00'
 (  !  + + !."!   % 0 "   0!"0 !
!  + 0 1 0  "0& " > !! !0 !  0$%! /
!'  5       !
      & 
K   
&  5"* 0 !0 
5""0! 0  +"0   
$ 0 5"! !   .00
 0 00' !"0  "*  +/
0 0! "00' " 2* 0&
 0!"0 "   !0  3"
"0 ! 0H    22   L  /!  + 0 < ! /
! &  ! < 0 " +1 / 00 0 !&  !5 0 0
!  2 " $@+!    !   !$% !    /
!"!% 0 !' < 3" $ / ( 0 0*  0 $,I&   !
4  5 '  $ ! 3" "0 / 0 $ !0 !  0! 
0"! % 2"&  "  .0!/3"?$! 3"   0/
2  ""' 0  ! 0 <
     &   0 / " 0   + 0  "0 9 ./
<  !' !"< !"   ! 0!  -:  
&  - 0 $" 
!!"! 0+2 3"    / $" ! +  0  $ 
" 00 ! 4   !(!'  !"  0 $/
G        2    00 0 ! <  0 $00
   2& "0 0H +(!  0 - 0 %  !!%' 
 3" !0   $00 0  ! < !"00  +1 ! 0 <
'  3" $  0 *  / $ <  "! ! 9$!%'
5"!   20'   "0  $00 0 H' ! < + 00 !%!:
!&  5 4  $0   !"  5  0  /
0!% !! 0 " !!% 00 0 2!  !."! <  0 
0 " +!! ! " $.   0 2! 0 !%  "0 &  /
' 00 "$   ! 0 . !"   0   ' "0 $/
+  +1 !'  3"  " 2* $ "/   !% 0 0H 0!0

C "1* M10* & ,CC7' 5" 8I& 5 0 0  ' !!% !& &&
,I NNNNNNNN& ,CCC' < 8& 5 0 0  &
CE 9 :'

3" $  $!% 0 *' ! 0!%  !' <    .0!
? 10 0 2 0 !1!  /    -    &&
2  0 "< ! !"!' 
5  " !O +1!! 0"!0   !" ! 0  < 7,7 0 ,CC= /
" !' " 2!"' " .! /   5!! 0  +% 0 - ! /
!' " 0 0 ! < &  0 ! 4 #2    .!
0 " +% < 0$   ! 
G    $   2& M! +! "0 020" < !!2' +!0 0 "
 " (   00 1 / !!00 !  + 0  "0' !/
52'  0 # +"D' !"< % !/ 0 !2    !!% 3" 5! 
0  !"  +! 02   00 0 !D& 0 !4
"0 0 "" 3"   " >!/ #"*    3" "! " !! /
!% !(+!&  5 ' ! !!/  +   0 0 !20/
  !! 0 0!   0 (! 3"  !  "0' "/
"  .0!/3"?$!  2 <  +"! 3"   0 " ! !
 2' 00  3"  0!  !  0$!  $  00
 $.! < "0 !"  +  $ 0   0!% 0  0" /
0+ 020"  020"&  " 0  !% 0  0"! +/
   0! !  " / !."!D'  !" !   !"/
! 0 0 !    ( <  0!/ 00 !2 0 4
% 00  + 0 2!
.0!,,&   *  0!%'  "0 G +&  + "  +% 
+  ! !  " 0 ! /
 3"  -'  . 0( 
!  0 3"!  (!& 5 4 "
2"!0' 3"  00
-  !0  "   /
! 0 !  .0! <  + &
5  "  !0   /
    &  $' . 0"!!%  ! !*!% 0 "!
 "0    5"! !0 (!&  !%  !" 0/
  "*!% !! 0 0!  !   !(" !' (!" 0* 0
 0$'  !" "0 0"! !!/ 0! ,C;=&  +! 1  0 
 02 %>!& 0! 0  !/ ! $'  !" "0  00
  0   0!% 0 /   0 !1!'   $ 0 0 /
0"! + !."! 3"  0 " *!%  00  5!  +%
+! 0 2! ' "0 0+! " +/    !   !"3" 
!!  0"!  $!% 0 0"! %>/ ( 3" $ !  ! /
!&  " 0 +1 !  > !%'   &  5 4 ! 0 0!/
! 0 +1 ! 3"  !0!0'   2!  ! !!/
 5  !!  " $'  "/  0 !"&
5  *0   H&  "  0/
!  3" "0 !! ! ' G  &  "! +!"!  !"/
 +  $2'  5   !!%    0  + 0 1 0
<  0!% 0   "+   "0  0 !$0   0/
0 !%  " "0 $*  00&   5 0   0
+! "!$.!&  00  !"00' !"0   " 2!
$2'    0  00 + !% < / +'   !% 0 !" 0H'

,, NNNNNNNNN & 5 0 0  & ,CCG'   ;&


     
 C

.  0"! 00   "0!' /  &  .  !"    0
$$!'  !    $" !!/ 00' !"0   "  
  !0  !0&  + !% !! < !  +  !
0H 3"  !"  020" "0 4  ""   0!  3" 
!   0&
D     & ! /
0 " 0!  9 0$:'   ! ;    H&  "< /
     !     '  0!' % 3" !   + " 
0 " (   + 00  '   !!"! 020 0  2!% 0
5 ' ! !   $'  !" "0   .!' "$ 0 !"   00 /
$ "+!!%   !& !' 3"  +!"   " 0+&
! ! 4 #%  .  2*D' # .
D    /  &  "/
0!"D' # 0 +"' *  3" 2'
0 0 4
<  0  "0  !' 0  !0D'
G :  & ! 0 " 0!/ "0 2   2!% 0 !1 .!
 9 0$:'   !   /  5 ' !  !! 02 0
 !  " (  900 &  0! ' !00 3"  +!/
5&:'  2% 0 "  +!   + !%$! 00 0 " $ 2/
00'  !0 !  0!/ 00 %$!&   0+  0
4 + !00! 0"!0   00' 14
 0* &  !   3"  !"/ G $  & ! 0 ! 
 ! ?    0 " +"!/ 0+!   " <  '  
 3"   0 " ! !' !        5" 00&
0 0$!' $0 !% 
 + 3"  !0 0! L . & "0    3"
+"!% 9 .0!' 2' 0/  "! 0!  ! +! 
$:'  3" "0 0 "$  !%  00  !'    5!
"0   <& " !% " < !(! $" /
0&  !" 3" ! !  3"
G : & "0  +   / 05 !&
0   '  $!   +
0 1!! < 00& 5 4 >0 G    & "   0 %0'
 "  "*0' 0!   /3"  !   !!%/' /
!!% .0!' +1 ! 0 ! 0 3"  !  "0 !" 0H&
!'  !"   $ 0  
" 0 $ ! 0 -"( /
!  !."!   (!" = "  ' * I: * +'
& 4  +    "00 ! / '*/:;:++ H: 
'  0+!!  $"00 / 5. H-: 
!0 !  0"! + !."!&
G / $$ &  +   !%  3" 3"  0"! !+   
0 " 2!  !  3"  3" / > '  !" ! +!   !1
!     "&  5 ' .! 3"  0 !0   5!!
 0   0  " +!/ 0  +% < 0  0  3"/
!  "  $"0'   %   0 H  ! + !."!& $"/
 0!"0  !"     0 /  4
CC 9 :'

P      !!2 !/ $         J?
0 !  "0 +   020"' 4    ! H&  !200  /
 H0 0 " !!00 !  +/ 2! 0 - <   0  /
 0  "0& 0   < 5  0  !00
0 20 0 ""& $" 0  $"
P ! "! %$  $ !!"! "0  " +! !/
  "0    0 !!    " % !' <  !"< 
03"0  "  ! 0  20 $24
"  < 3" !2$   "0 < 
 0  0 1& P !! 3" 2" '  0 0
"0 0 ! 3" "0   !
P  +!  !!  + !."!    + !%$!&
 5" 00' !"0  3"0'
0 !!   !0! 0 !/ P
$ 3" " 0!  "0 0"/
& ! !" 0 0+ $0'   3" 
0 !    !4'  0 0
P  ! $"     0 )/ "0  ' 0" < 0". 0 /
( 0 00 0 +1 ! 00 " 0H'   + !."!' " !0!/
0' 0"!!%' ! 0 !00 0  +(! < " 0 (3"! < ( !&
0"!  0' 0!% < +!
0 " "& P  !  "" " ! 
+ 0 < 0   0 /
P  ! $" ' ! < 2"!%' &
!"0  0 " !" !  ! /
 0  0+ 0!  < P ! ( " !% !   2
2!  " "$ 0 5' !  + 0 0 0"! $
0+! " 000  5 "
!0!  " +""  0' "!/ P +! " ("     +"!/
0 (   0  ! "00&   0 !  + !."!'
  2!"0 $?  $!% 2/
P  ! " ! !!% $&
2 !  + 0 1
0  "0' 0   3"  $ / P    !+0!00 +'
  !  !* !  0!/  !" !"< "! 2   3"
 !0 !  "0 <   < >$ ! 2&
+1 ! "*0   2! 0 / P  $  0200   < 
!%  "0& 0  0  !"  /
P  !   !  00 0   +!!% 0  0"! +/
3" H  5 0!"0 0 0! !."!&
"   0"!!% 0 0! / P  0 " " 5 < 0!%  
 < 3" "0   !   0" %>!' 0 2 /
$2&   ! &
P  ! < ! !2  ! P      0 + !% 
 -'  0 !'   3"  "/ 0 0$0   ! "00  $' 
0 !"   $$!      2 ! H 3" !"  " !/
020"   !!200'& ! 0  0!    !%&


     
 CD

P  0"!   "00 ! / ! < $!A $"0 "   !/
  5!! (! 0  !200 / 0"! $" 0 !%&
+ 9!" =7' -:&
 - !    0 +*  
*'+ / :*/+*&  0*5 0  !! + !."!' !
" 0 /35 !     /    ! 0  00 !2'
$"   ! .!/+ 3"  .! < A !!0  0 % < 
 01  5"! 0  !! $  !! 3" . 02   02/
3"  02 0  2$! 3" 0/ 0" !  !"0   !"" 0
  $  0 2$! < !' " '   "* 0  < <    
 2!%   $(  5"(0!&  /  !"  ! "   3"  /
  " 0 .! +     !! 0 H 0  <' 3" 1
!"3" !%  ! 0 + !  ./  2$"0  0 !' 0 
! +'   !" 01  !" 
' 0   < 0  !%  $&
"* 0   '  $200' !0/
! <  !0 0 !"0&  /   !10 0  $  0 - <
 ! 3"  "0 ! 4   ! 0 0!"  < < /
 !     !0. ! !(+/
D  !% 20& ! 0  !000&  +   !" /
  " 0   &
D  !% ! < ?!
   0+!  !!  <
D  !% 2 < ?!&  1!! 3"   - <   
D "% 0 5!! +   " 00 < !     /
0* H& ! 0  $!% 2$&

*/ ;-:*/' ' *.'/+ :>/

  - <    " 0 2     200'
'  <
   !2' .! <   " 0/    $"  0 "0 + 
 H +' 20   " ! % !  0!
0  "0 020" < !!2' +!0  "!"' 0 <   !
0 " !!00 < !0 !2   ! "!!% +!2 0 "   0 /
0  !!% 3" 5!  00 0 !& + !%   < <  0! 2$/
' "  !! < !0! !  "
 00 .!' !2 < / (! ?!' 0 !200 ! 
  0+(! 0 0+!  3"  3"/ 2 !(+!/.!! 9+'  '
  0 " 0 ' !0"!  / 5!! 1!!' !" 0 + !% !/
0 !"   0  0 1&   "0   1 5"(0!' !0 !
!%0$ 0 .! 1 0!  0' 0/  !! + !."!&
CF 9 :'

'5''/ : :;:*KL5: 

,&  QR )K' 


  &   $ 0 $/ G& ?! 0  '  0 "0' "!% 8CCG'
( 0  !00 < 00 .0!& 4 .0!/ / ;7;E < ;7=7& +. 0 $1' ,CCF&
$& 2     + 0  "0&
H R
' & 7' </$' & ,C  7F& 7III& E& ?! 0  ' $ 0  ?!& < ;E=
0 ,CCE& $   +% 0 .!$  $/
7& QK R )
& 00 0  ! 0  !& +. 0 $1' ,CCE&
+ 0  "0& ! S"(0! O& 2
0!%& 1" ;8' & ;EC  =,=& C& 
 )& 2!% 0 $ S"(0!    /
H +& 4 4 #   < +
8& ?! 0  ' $ 0  ?!& < 78 0   "00 0 ! ! !D& 200
,CE,&     0 T! .0!& +. 0 / +! 2' &;' ,CCG&
$1' ,CE,&
,I&  U' )
&    /
;& ?! 0  ' $ 0  ?!& < ,II 00 !2 .0!  " <  & 4 .0!/ /
0 ,CC8&   0 $"00 !
$   ' $& 2     + 0  "0&
!" 7;=& +. 0 $1' ,CC8 H R
' & 7' </$' & ,;  ,E& 7III&

=& ?! 0  ' $ 0  ?!& < FI 0 ,,&    S


 VK& W $! 0 5 0
,CC8& +. 0 $1' ,CC8& "+! < " 20* $X& " " 0
0(& 4 " < !' &,I' 0('
/
F& ?! 0  '  0 "0' ! ,EC,  -" ' &C8/C=& < ,I 0 ,CEC' &&
$   < FI 0 ,CC8& +. 0 $1' ,CC;&

1
'
4 ""565"

 
4 """55"

You might also like