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Scaffolds para regeneração do tecido ósseo

Microestrutura do Scaffold Parâmetros Ref


Espessura do scaffold: 30µm [1]
Ø fibra: 590 nm ± 26 nm

Espessura do scaffold: 5µm [2]


Ø fibra: 238 nm ± 40 nm

Espessura do scaffold: 17µm ± [3]


3 µm
Ø fibra: (não informado no
artigo)

Espessura do scaffold: (não [4]


informado)
Ø fibra: 364 nm ± 222 nm
Espessura do scaffold: (não [5]
informado)
Ø fibra: 100 nm – 600 nm

Espessura do scaffold: 125 µm [6]


Ø fibra: 0,7 – 2 µm

Espessura do scaffold: não [7]


informado
Ø fibra: 2,15 µm

Espessura do scaffold: não [8]


informado
Ø fibra: 4 - 10 µm
Tamanho poros: 20 – 45 µm

Espessura do scaffold: 150 µm [9]


– 300 µm
Ø fibra: 3 - 5 µm

Espessura do scaffold: 70 µm [10]


Ø fibra: 0,28 – 0,52 µm
Espessura do scaffold: 450 µm [11]
Ø fibra: 565.57 ± 185.50 nm
Tamanho poros: 80 - 350 nm

Espessura do scaffold: 5mm [12]


Ø fibra: 1 µm

Espessura do scaffold: 0,52 ± [13]


0,06 mm
Ø fibra: (não informado)

Referências
1. Wang, A.; Hu, M.; Zhou, L.; Qiang, X. Self-powered well-aligned P(VDF-TrFE)
piezoelectric nanofiber nanogenerator for modulating an exact electrical
stimulation and enhancing the proliferation of preosteoblasts. Nanomaterials 2019,
9, 1–16, doi:10.3390/nano9030349.
2. Toullec, C.; Bideau, J. Le; Geoffroy, V.; Halgand, B.; Buchtova, N.; Molina‐peña,
R.; Garcion, E.; Avril, S.; Sindji, L.; Dube, A.; et al. Curdlan–chitosan electrospun
fibers as potential scaffolds for bone regeneration. Polymers (Basel). 2021, 13, 1–
14, doi:10.3390/polym13040526.
3. Kitsara, M.; Blanquer, A.; Murillo, G.; Humblot, V.; De Bragança Vieira, S.;
Nogués, C.; Ibáñez, E.; Esteve, J.; Barrios, L. Permanently hydrophilic,
piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical
stimulation on osteoblasts. Nanoscale 2019, 11, 8906–8917,
doi:10.1039/c8nr10384d.
4. Zhang, Y.; Wang, T.; Li, J.; Cui, X.; Jiang, M.; Zhang, M.; Wang, X.; Zhang, W.;
Liu, Z. Bilayer Membrane Composed of Mineralized Collagen and Chitosan Cast
Film Coated With Berberine-Loaded PCL/PVP Electrospun Nanofiber Promotes
Bone Regeneration. Front. Bioeng. Biotechnol. 2021, 9, 1–12,
doi:10.3389/fbioe.2021.684335.
5. Feng, T.; Liang, B.; Bi, H.; Han, Y. A sandwich-like structure composite
electrospun membrane of polylactic acid/nano-hydroxyapatite and polyvinyl
alcohol/sodium alginate/nano-hydroxyapatite for skull defect repair. Mater. Des.
2021, 209, 109957, doi:10.1016/j.matdes.2021.109957.
6. Wang, S.; Suhaimi, H.; Mabrouk, M.; Georgiadou, S.; Ward, J.P.; Das, D.B.
Effects of scaffold pore morphologies on glucose transport limitations in hollow
fibre membrane bioreactor for bone tissue engineering: Experiments and numerical
modelling. Membranes (Basel). 2021, 11, doi:10.3390/membranes11040257.
7. Yang, N.; Moore, M.J.; Michael, P.L.; Santos, M.; Lam, Y.T.; Bao, S.; Ng,
M.K.C.; Rnjak-Kovacina, J.; Tan, R.P.; Wise, S.G. Silk Fibroin Scaffold
Architecture Regulates Inflammatory Responses and Engraftment of Bone
Marrow-Mononuclear Cells. Adv. Healthc. Mater. 2021, 10, 1–14,
doi:10.1002/adhm.202100615.
8. Luo, J.; Zhu, J.; Wang, L.; Kang, J.; Wang, X.; Xiong, J. Co-electrospun nano-
/microfibrous composite scaffolds with structural and chemical gradients for bone
tissue engineering. Mater. Sci. Eng. C 2021, 119, 111622,
doi:10.1016/j.msec.2020.111622.
9. Smoak, M.M.; Hogan, K.J.; Grande-Allen, K.J.; Mikos, A.G. Bioinspired
electrospun dECM scaffolds guide cell growth and control the formation of
myotubes. Sci. Adv. 2021, 7, doi:10.1126/sciadv.abg4123.
10. Wu, Y.; Fuh, J.; San Wong, Y.; Sun, J. A hybrid electrospinning and
electrospraying 3D printing for tissue engineered scaffolds. Rapid Prototyp. J.
2017, 23, 1011–1019, doi:10.1108/RPJ-08-2015-0111.
11. Elkhouly, H.; Mamdouh, W.; El-Korashy, D.I. Electrospun nano-fibrous bilayer
scaffold prepared from polycaprolactone/gelatin and bioactive glass for bone tissue
engineering. J. Mater. Sci. Mater. Med. 2021, 32, doi:10.1007/s10856-021-06588-
6.
12. Jirkovec, R.; Holec, P.; Hauzerova, S.; Samkova, A.; Kalous, T.; Chvojka, J.
Preparation of a Composite Scaffold from Polycaprolactone and Hydroxyapatite
Particles by Means of Alternating Current Electrospinning. ACS Omega 2021, 6,
9234–9242, doi:10.1021/acsomega.1c00644.
13. Lian, M.; Han, Y.; Sun, B.; Xu, L.; Wang, X.; Ni, B.; Jiang, W.; Qiao, Z.; Dai, K.;
Zhang, X. A multifunctional electrowritten bi-layered scaffold for guided bone
regeneration. Acta Biomater. 2020, 118, 83–99, doi:10.1016/j.actbio.2020.08.017.

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