Data Sekunder (Medline)

Data Tersier ( DIH edisi 20)

Adverse Reaction Frequency not defined :
Cardiovascular :
Acute cardiotoxicity : Atrioventicular block, bradycardia, bundle branch block, ECG
abnomartitias, extrasystoles (atrial or ventricular), sinus tachycardia, ST-T wave
changes, supraventricular tachycardia. Tachyarhythmia, vebtricular tachycardia.
Delayed cardiotoxicity : LVEF decreased, CHF (manifestations include ascites,
cardiomegaly, dyspnea, edema, hepatomegaly, oliguria, pleural effusion, pulmonary
edema, tachycardia, myocarditis, pericarditis.
Central nervous system : Malaise
Dermatologic : Alopecia, Iching, photosensitivity, rash ; discoloration of saliva,
sweat, or tears.
Endocrine and metabolic : Amenorrhea, dehydration, Infertility ( may be temporary),
hyperuricemia.
Gastrointestinal : Abdominal pain, anorexia, colon necrosis, diarrhea, GI ulceration,
mucositis, nausea, vomiting.
Genitourinary : Discoloration of urine.
Hematologic : Leukopenia/neutropenia (75% ; nadir ; 10-14 days ; recovery ; by day
21) ; thrombocytopenia and anemia.
Local : Skin “flare” al injection site, uticaria
Neuromuscular and skeletal : weaakness
Postmarketing and/or casa reports : Anaphylaxis, azooapermia, bilirubin increased,
chills, coma (when in combination with cisplatin or vincristine), conjunctivitis, fever,
gonactat impairment (children), growth failure (prepubertal), hepatitis,
hyperpigemntation (nall, skin and oral mucosa), infection, lacrimation,
myelodysplastic syndrome, neutropanic fever, oligospermia, onycholysis, paripheral
neurotoxixity (with intra-arterial doxorubicin), phlebonclerosis, radiation recal
pneumoritis (children), secondary acute myelogenous leukomia, seizure (when in
combination with cispkatin or vincristina), sepsis, shock, systemic hypersensitivity
(including urticaria, pruritus, angioderma, dysphagia, and dyspnea), transaminases
increased, urticaria.