Experimental Alloxan Alloxan Alloxan

Alloxan DM&50mg\kg DM&100mg\kg DM&200mg\kg

Groups HFD
treated DM
Test Mean Curcmin Curcmin Curcmin
Mean± SEM
Parameters e Mean± SEM e Mean± SEM e Mean± SEM
375.93±22.6* 235.9
Glucose 248.3±13.5*** 188.2±5.5***
** ±16.3***
(mg/dl) 186.5±15.8
 Experimental Alloxan Alloxan Alloxan
Alloxan DM&50mg\kg DM&100mg\kg DM&200mg\kg
Groups HFD
treated DM
Test Mean Curcmin Curcmin Curcmin
Mean± SEM
Parameters e Mean± SEM e Mean± SEM e Mean± SEM
8.98 ± 0.39
HbA1c 6.48 ±0.39*** 6.72 ±0.34*** 6.25 ±0.41***
4.45 ±.38 ***
%

C –peptide .38± 0.03*** 0.72±0.4 ** .83±0.4 *** 0.97±0.5 ***

1. 7± 0 .9
(ng/ml)
Table (8): Effects of (100,150,200mg\kg) of Oral Mangeferin Extract
on Adipokines and Antioxidant Levels in HFD Alloxan Diabetic
Rats.
Experimental
Alloxan
Alloxan Alloxan Alloxan
Groups
treated DM DM&100mg\kg DM&150mg\kg DM&200mg\kg
HFD

Mean Mangeferin Mangeferin Mangeferin

Test Mean± Mean± SEM Mean± SEM Mean± SEM
SEM
Parameters

Leptin

(ng/dl) 91.00±4.6 148.5±6.1Ɨ 115.9±3.8*** 108.5±3.7*** 91.5±5.69***

P˃ 0.050 P<0.001 P< 0.001 P< 0.001

295.4±10.8
325.3±17.27 Ɨ 364.8±10.7 *
8Ɨ 335.09±13.23 Ɨ
Adiponectin 350.27±18.03
(µg/ml)
<0.05 P
P˃ 0.050 P˃ 0.050 P˃ 0.050
Chemerin 30.32 ±2.2 Ɨ 22.60± 0.8** 18.63±1.68*** 15.47±0.7***
24.85±1.6
(µg/ml) P˃0.050 P<0. 01 P< 0.001 P< 0.001

23.16 ±1.7
30.02 ±1.97 Ɨ 31.13±1.96 * 33.62±1.51***
SOD (u/L) 30.01±2.58 Ɨ

P˃ 0.050 P˃ 0.050 P<0.05 P<0.001

25.85 ±1.66 37.10±1.71** 39.60±1.87 *** 42.80±2.33 ***

GPx (u/L) 33.57±2.88
P˃ 0.050 <0. 01 P < 0.001 P P< 0.001
Table (9): Effects of (100,150,200mg\kg) of Oral Mangeferin Extract
on Adipokines and Antioxidant Levels in HFD Alloxan Diabetic
Rats .
Experimental
Alloxan Alloxan Alloxan
Alloxan
Groups DM&100mg\kg DM&150mg\kg DM&200mg\kg
HFD treated DM
Mangeferi Mangeferi Mangeferi
Mean
Test
n n n
Mean± SEM
Mean± SEM Mean± SEM Mean± SEM
Parameters

Glucose 375.93±22.6*
186.46±15.8 247±8.9 *** 243±9.30 *** 217±12.6 ***
**

(mg/dl) P< 0.001 P< 0.001 P< 0.001 P< 0.001

Table (9): Effects of (100,150,200mg\kg) of Oral Mangeferin Extract

on Adipokines and Antioxidant Levels in HFD Alloxan Diabetic
Rats .
Experimental
Alloxan Alloxan Alloxan
Alloxan
Groups DM&100mg\kg DM&150mg\kg DM&200mg\kg
HFD treated DM
Mangeferi Mangeferi Mangeferi
Mean
Test
n n n
Mean± SEM
Mean± SEM Mean± SEM Mean± SEM
Parameters

185.53±12.2
183.07±14.92 176.41±4.20 Ɨ 169.15±7.12 Ɨ 136.24±6.2 *
Cholesterol(mg/dl) Ɨ
P˃ 0.05 P˃ 0.05 P˃ 0.05 P<0.05

TGs (mg/dl) 89.33 ± 6.4 111.31±10.3 94.14±5.7 Ɨ 87.03±4.7 Ɨ 77.73±6.4 **

Ɨ
 P˃ 0.05 P˃ 0.05 P˃ 0.05 P<0. 01

58.60±4.08 47.60±4.09
89.89±5.4 ** 67.10±2.7 **
61.76±3.3 *** ***
LDL-c (mg/dl)
P<0. 01 P< 0. 01 P< 0.001 P< 0.001

31.44±1.97 27.96±2.33 Ɨ 30.47±1.67 Ɨ 30.62±2.63 Ɨ 32.95±2.12 Ɨ

HDL-c (mg/dl)
P˃ 0.05 P˃ 0.05 P˃ 0.05 P˃ 0.05