PRODUCT INFORMATION

25I-NBOH (hydrochloride)
Item No. 14909

CAS Registry No.: 1539266-12-0

Formal Name: 2-(((4-iodo-2,5-
dimethoxyphenethyl) O
H
amino)methyl)phenol,
monohydrochloride N
Synonym: 2C-I-NBOH
MF: C17H20INO3 • HCl OH
FW: 449.7 I • HCl
Purity: ≥95%
O
Stability: ≥2 years at -20°C
Supplied as: A crystalline solid
UV/Vis.: λmax: 299 nm

Laboratory Procedures

For long term storage, we suggest that 25I-NBOH (hydrochloride) be stored as supplied at -20°C. It should
be stable for at least two years.
25I-NBOH (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the
25I-NBOH (hydrochloride) in the solvent of choice. 25I-NBOH (hydrochloride) is soluble in organic solvents
such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The
solubility of 25I-NBOH (hydrochloride) in ethanol is approximately 20 mg/ml and approximately 30 mg/ml in
DMSO and DMF.
25I-NBOH (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous
buffers, 25I-NBOH (hydrochloride) should first be dissolved in DMF and then diluted with the aqueous
buffer of choice. 25I-NBOH (hydrochloride) has a solubility of approximately 0.5 mg/ml in a 1:10 solution of
DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one
day.

Description

25I-NBOH is a derivative of the phenethylamine hallucinogen 2C-I (Item No. 11113) with an
N-(2-hydroxybenzyl) addition at the amine. It can act as a potent agonist for the human serotonin 5-HT2A
receptor (Ki = 0.061 nM) with 12-fold greater potency compared to 2C-I itself.1-2 This product is intended for
research and forensic applications.

References

1. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues
Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Mol. Pharm. 70(6),
1956-1965 (2006).
2. Ettrup, A., Hansen, M., Santini, M.A., et al. Radiosynthesis and in vivo evaluation of a series of substituted
11C-phenethylamines as 5-HT
2A agonist PET tracers. Eur. J. Nucl. Med. Mol. Imaging 38, 681-693 (2011).

WARNING CAYMAN CHEMICAL

THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD
SAFETY DATA ANN ARBOR, MI 48108 · USA
This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after
handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897
WARRANTY AND LIMITATION OF REMEDY [734] 971-3335
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