Pioneers International School

American division

Biology Department

Grade 11
Third quarter

Molecular genetic
1. Choose:
1. From his work with mice and pneumonia-causing bacteria,
Frederick Griffin coined the term..........................
a. Replication
b. Transcription
c. Transformation
d. Translation

2. Using the image what happened to the mice labeled X and Z?

a. Both X and Z died

b. Both X and Z lived
c. X died and Z lived
d. X lived and Z died
3. Who FIRST showed that DNA was the transforming factor?
a. Griffith
b. Avery
c. Chargaff
d. Franklin

4. Which scientists used viruses and radioactive isotopes to

definitively prove that DNA, and not protein, was the molecule of
heredity?
a. Griffith and Avery
b. Chargaff and Franklin
c. Watson and Crick
d. Hershey and Chase
5. Which two radioactive isotopes were used to label the DNA and
protein components of viruses called bacteriophages?
a. Nitrogen and Phosphorus
b. Phosphorus and Sulfur
c. Nitrogen and Sulfur
6. which was a conclusion of Griffiths work with Streptococcus
pneumonia?
a. DNA is the genetic material in Viruses
b. The structure of DNA is a double helix
c. Bacteria exposed to DNA can incorporate the DNA and change
phenotype
d. The amount of thymine equals the amount of adenine in DNA
7. This scientist(s) found a "transforming principle" that changed
harmless bacteria into harmful bacteria
a. Mendel
b. Avery
c. Chargaff
d. Griffith

8. The scientist(s) who settled the debate about whether it was

proteins or DNA that was the genetic material of the cell
a. Avery
b. Hershey & Chase
c. Watson & Crick
d. Griffith
9. Bacteriophages are
a. Viruses
b. Bacteria
c. Prions
d. Viroids
10. In Hershey Chase experiment, Protein tagging was done by-
a. Radioactive Phosphorus P37
b. Radioactive Sulphur S 34
c. radioactive Sulphur 35 S
d. radioactive Phosphorus 32 P
11. Hershey-Chase experiment confirms that:
a. DNA is always formed from DNA in semiconservative manner.
b. Sulphur and Protein both enter in bacterial cell progeny.
c. DNA is genetic material ,not protein.
d. Radioactive Phosphorus was only found in surrounding.
12. Avery added an enzyme known to break down proteins to his
extract, and saw that the bacteria were .........................
a. still transformed
b. not transformed
c. all killed
d. all sick
13. By using radioactive isotopes, Hershey and Chase were able to
conclude that __ is/are the carrier(s) of genetic information.
a. nucleic acid
b. Proteins
c. Carbohydrates
d. Lipids
14. Which two radioactive isotopes were used to label the DNA
and protein components of viruses called bacteriophages?
a. Nitrogen and Phosphorus
b. Phosphorus and Sulfur
c. Nitrogen and Sulfur
15. Which scientist conducted the experiment pictured?
a. Chargaff
b. Griffith
c. Hershey
d. Watson
16. In the late 19th and early 20th century, most scientists believed
that ________ was the genetic material because it offers more
potential complexity.
a. carbohydrate
b. protein
c. DNA
d. lipid
17. Frederick Griffith made his important observations about
"transformation" while attempting to develop a vaccine against which
pathogenic organism?
a. E. coli
b. Bacteriophage
c. HIV
d. S. pneumonia
18. When Frederick Griffith coined the term "transformation," this was
in reference to the genetic re-programming of
a. strains of bacteria.
b. laboratory mice.
c. patients with pneumonia.
d. bacteriophages.
19. In the famous Avery, MacLeod, and McCarty experiment, the tube
that was treated with _______ resulted in the destruction of the
"transforming material."
a. lipase
b. RNase
c. DNase
d. protease
20. The Hershey and Chase experiment served as powerful
independent confirmation that DNA was indeed the genetic material.
They made their discovery using which type of organism?
a. S. pneumonia
b. mice
c. strains of bacteria
d. bacteriophage
21. As determined by Frederick Griffith's experiment, when DNA is
"transformed"
a. its structure completely changes.
b. it produces a slightly different organism.
c. its structure does not change at all.
d. it produces a pathogenic organism.
22. After Griffith's results were made known, scientists all over the
world began to repeat his experiment in slightly different ways. Which
statement BEST explains why that happened?
a. The scientific community did not trust Griffith's results.
b. Scientists wanted to build on and extend his research.
c. Scientists in different countries were competing to prove Griffith
wrong.
d. Scientists wanted to create new forms of S. pneumonia.
23. What were the results of the Avery, McCarty, Macleod experiment?
a. The flask with no protein had no S cells
b. The flask with no RNA had no S cells
c. The flask with no DNA had no S cells
24. What was the conclusion that Avery, McCarty, and MacLeod drew
from their results?
a. DNA is responsible for transforming type S cells into type S cells
b. DNA is responsible for transforming type R cells into type S cells
c. DNA is responsible for transforming type S cells into type R cells
25. Whose experiment were Avery, McCarty and MacLeod trying to
prove?
a. Thomas Hunt Morgan
b. James Watson
c. Francis Crick
d. Frederick Griffith
26. What two organic compounds did Avery, McCarty and MacLeod
remove at the beginning of the experiment since they were not
believed to be the transforming principle?
a. Carbohydrates, Lipids
b. DNA, RNADNA, Protein
c. Enzymes and Carbohydrates