Professional Documents
Culture Documents
INTRODUCTION
© WHO/Blink Media ‒ Fabeha Monir
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Strategic planning
© WHO/Lorenzo Pezzoli
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© WHO/Jawad Jalali
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ULT requirements
• For mRNA vaccine types
• Challenging without transport links, refrigeration facilities or
stable power supplies
+8C
Liquid Lyophil Liquid Lyophil Liquid Lyophil Liquid Lyophil
OPV OPV
Acceptable Acceptable
+2C
-15C
Lyophil Lyophil
OPV OPV
-25C
Note: Diluents should never be frozen. If diluents are packaged with vaccine, the package should be stored at +2 to +8 C.
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+8C
Liquid Lyophil Liquid Lyophil Liquid Lyophil Liquid Lyophil
Ebola
OPV OPV COVID-19
Acceptable Acceptable
+2C
Targeted
-15C
Lyophil Lyophil
Ebola Ebola
COVID-19 COVID-19
OPV OPV
-25C
Expected Expected
-60C
Ebola Ebola Ebola Ebola
COVID- COVID- COVID- COVID-19
19 19 19
-80C
Note: Diluents should never be frozen. If diluents are packaged with vaccine, the package should be stored at +2 to +8 C.
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Key challenges
Establishing ultra-cold chain (UCC) systems
is not easy.
Key challenges
© WHO/Lindsay Mackenzie
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• Responsibility of manufacturer
© WHO
©WHO/unifeed180529i
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Vaccine arrival
International shipping of ULT vaccine is the responsibility of manufacturer.
ULT STORAGE
© WHO/Saya Oka
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© WHO/Magnus Manske
• Low installation compared with WICR
© WHO
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IN-COUNTRY TRANSPORT
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© WHO Philippines
© WHO/Mark Nieuwenhof © WHO HQ/WHE
© WHO HQ/WHE © WHO/Daria ©WHO HQ/WHE
Lourenco
© Noun Project/Paulius B.
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Water/ice packs
• Phase-change temperature: 0 °C
• Latent heat of phase change: 335 kJ/kg
• Method: fill packs with water and freeze at
-1 °C
• Uses: packing vaccines for vaccination
session, maintaining vaccines cool during
transportation or session
• Suitable containers:
• vaccine carrier/ transport box
• thermal shipper
• Arktek (with plastic water packs)
© WHO/Jawad Jalali
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© WHO/Mark Nieuwenhof
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© WHO HQ/WHE
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Thermal shipper for dry ice Dry ice only • No initial investment • Prone to wear and tear
• Usually comes with temperature • Use with dry ice only for ULT
logger • Consistent re-icing to maintain
• Large capacity range: 3.4 L to 6.2 L ULT: never allow dry ice to be
• May come with vial rack system depleted.
• Cold life: product specific; on
average 5 days with two
openings/day, extended with
consistent re-icing
© WHO HQ/WHE © WHO/Mark Nieuwenhof
• Reusable dry ice
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1. Estimate the number of thermal shippers and vaccine trays for delivery of needed
quantity of vaccine; estimate the quantity of dry ice according to the size of the thermal
shippers.
2. Inspect each thermal shipper, ensure it is clean, without damage or signs of wear and
tear.
3. Take the thermal shippers to well a ventilated area.
4. Load each thermal shipper one at a time, only load the second box once the first box is
completely loaded, sealed and labeled for delivery.
5. Wash hands thoroughly and wear PPE (i.e. insulated gloves and eye shield).
6. Fill the bottom third of the box with dry ice using a small metal or hard plastic shovel
7. Load vaccines into the vaccine tray/box documenting vaccine product and quantity, lot
number, and expiration/manufacturing date, if available.
8. Place tray/box containing the vaccine in the middle of the shipper.
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*Do not keep the thermal shipper with dry ice in an enclosed compartment! © HZJZ Croatia
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1 Fill PCM
2 Pre-freeze
3 Freeze
4 Load
STEP
respiratory masks,
insulated gloves) • Duration: 24 hours • Duration: 48 hours • Frozen PCM
packs
• Filling equipment
(siphon, funnel, pump) • Duration: ˃4 hours
• Materials and
accessories: can with
PCM liquid spanners
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© WHO HQ/WHE
contains 1 liter of liquid PCM.
4. Fortify the screw with white tape before screwing it
back on the PCM pack. This will prevent any leakage
during use.
Photo: WHO
Preparing PCM pack
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freezing process for the next 8 PCM packs. Cross section view of Arktek long-
duration passive ultra-cooler (LDPU)
• Do not condition PCM in the ULT freezer where vaccine is stored. Use
Photo: WHO
smaller ULT freezer for preparing and storing PCM.
Photo: WHO
• Transfer the frozen PCM to Arktek as needed.
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Intellectual Ventures
PCM packs. Pre-cool Arktek for 4 hours or more.
© Global Good/
Internal temperature
• When -75 °C to -65 °C temperature is reached, replace the PCM packs monitoring system
with another frozen set. Return the used set of PCM packs to ULT freezer and screen and
for reuse. probes location.
• Take the vaccine out of ULT freezer and place in the vial racks. Ensure the
vial rack is always placed in the middle.
• Minimize vaccine exposure to ambient temperature to less than 3 minutes.
• Close the Arktek lid and insert the batteries into the temperature monitoring
device. They should not be activated before the Arktek is loaded.
• Turn on the temperature control monitor.
© Global Good/
Intellectual Ventures
Photo: WHO
Vaccines can be stored in Arktek without replacement of PCM packs for up to 5 days. Vial rack system
Packing & transporting
Transport vaccineat- Options
to and storage service points
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© WHO/Lindsay Mackenzie
The length of time thawed vaccines can be stored at
+2 to +8 °C in vaccine carriers may vary by product.
SAFETY CONSIDERATIONS
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© WHO/Light in Captivity
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Danger of Low
asphyxiation temperature
warning
SAFETY MEASURES
• Rapid deployment
© WHO/Christopher Black
• where districts are close to central
storage
For the purpose of sizing, keep in mind that when using ULT freezers, only about 50% of the storage capacity
is used. Therefore, for a ULT freezer of 700 L, only about 350 L would be used.
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Cascade deployment
For countries with districts >1 day distance to central storage:
Central
store
• Cascade storage points at each level
• Inventory management
• Temperature tracking
Subnational
store
Service
point
District (lower
distribution) store
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Subnational
store
Site A Service ULT freezers
points
Site B
Vaccine carriers at Long-range storage
Site C District (lower equipment (3–5 days)
each site (1 day)
distribution) store
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Rapid deployment
Central
For countries with districts at <1 day store
distance to central storage:
Service
points
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Central
• If central to district transport takes store
less than one day, transport directly
to service points with vaccine ULT freezers
WHO/Fanjan Combrink
• ULT freezers to match vaccine volume
• Standard vaccine carriers
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© WHO/Sephi Bergerson