Your Roll No……………………

SCHOOL OF PHARMACEUTICAL EDUCATION & RESEARCH, JH

B. Pharm. IV Semester Examination, 2021

PHARMACEUTICAL ORGANIC CHEMISTRY III (BP401T)

Time: Three Hours Date: 28-06-2021 Maximum Marks: 75

(Write your roll no at the top immediately on receipt of this question paper)

Note: (i) Attempt all Sections

(ii) Marks are indicated against all questions

SECTION-A
Short answer Type Questions (Answer all the questions in brief) [10x2 = 20 Marks]

Q.1: Define enantiomers, its conditions with suitable example

Q.2: Mention two rules for nomenclature of Heterocyclic Compounds
Q.3: Explain the relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
Q.4: Mention Wolff-Kishner reduction reaction
Q.5: Describe Chiral and achiral molecules
Q.6: Write reaction involved in Claisen-Schmidt condensation
Q.7: Explain the aromaticity of Pyrazole
Q.8: Draw the structure of oxazole containing drugs
Q.9: Using structural example differentiate between Cis and Trans system
Q.10: Draw the structure of purine and aziridine

SECTION-B

Long Answers (Answer TWO out of THREE) [2x10 = 20 Marks]

Q.1: Describe Atropisomerism and Le Bel-van't Hoff Rule with suitable example
Q.2: Discuss mechanism of any two of the following name reactions:
Lithium aluminium Hydride reduction reaction, Electrophilic substitution in Pyrazole,
Dakin reaction
Q.3: Discuss method of preparation and medicinal uses of oxazole and thiazole

SECTION-C
Short Answers (Answer SEVEN out of NINE) [7x5 = 35 Marks]

Q.1: Discuss electrophilic reaction in Imidazole

Q.2: Draw the conformational isomer in Cyclohexane. Also explain it
Q.3: Explain the chemical reactions of Pyrrole and Thiophene
Q.4: Write a note on basicity of Pyridine
Q.5: Write the Mechanism of Schmidt rearrangement.
Q.6: Differentiate between LiALH4 and NaBH4 reduction reaction
Q.7: Explain Skraup Quinoline synthesis
Q.8: Describe Chichibabin reaction
Q.9: Electrophilic attack in Imidazole occurs at N-3 but not at N-1. Why?

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