pjetive: To prepare and evaluate sustained release matrix tablets using natural polymers gsrelease modifiers THEORY Matec aystern i the most innumerable medROe used in the development of sustained release formulations. It is the release system, which prolongs and controls the release of drug that is ssolved or dispersed. In fact, a matrix defined as a well mixed composite of one or more drugs with a gelling agent, hnydrophilic polymer. Natural polymers have een extensively tused in the field of drug delivery ‘because they are readily available, cost effective ecofriendly, capable of multitudes of chemical modifications, potentially degradable and compatible due to their natural origin, Xanthan gum is a high molecular weight extracellular polysaccharide, produced on commercial scale by the viscous fermentation of gram negative bacterium Xanthomonas ‘campesteris. The molecule consists of a backbone identical to that of cellulose, with side chains creed to alternate glucose residues. Itisa hydrophilic polymet ‘which until recently had been finited for use in thickening, suspending and emulsifying waler based systems. It appears to te gaining appreciation fr fabrication of matrices, as 00% only retards drug release, butalso provides time independent release Kinetics with ‘added advantages of biocompatibility and Pei Release cf soluble drugs was mainly through diffusion, Wiss sparingly soluble orinsoluble drugs were released via erosion. Itis also eecommended for use in both acidic and alkaline systems. Xanthan gum has been ‘evaluated asa hydrophilic matrix for ‘controlled release preparation, using different model drugs including, theophylline, cephalexin, prednisolone and indomethacin ‘Alginate has been used successfully for many YET thickening agent, gelling agent and colloidal stabilizer Alginate properties thet have enabled it to be used as a matrix for the entrepms Variety of proteins and cells. These properties include: ()) A relatively inert aqueous environment within the matrix (i) A mild room temperature encapsulation process free of organic solvents (ii) high gel porosity which allows for high diffusion rates of macromolecules (iv) The ability to control this porosity with simple coating procedures v) Dissolution and biodegradation of the system under normal (vi) They are widely used in food and ‘pharmaceutical industries st i binder, thickening and stabilizing agents in mstures ‘and as gelling agents: at||j Peat Maal on advances Phamaceuis Formula it) 100 call tat 1 of 2 100 ee on 3. 100 vege 4 100. ve 5 100 : 100 - 6 [00 : [so a Ss PROCEDURE Determination of Viscosity of Different Gums by Brookfield Viscometer Before using the gums, the viscosity of 0.5%w/v solution of gums were determined, Brookfield viscometer with spindle No. 3 at 37°C. The highest viscosity combination was qq sidered suitable for good polymer for dosage form Preparation of Sustained Release Matrix Tablet using Natural Gums * Matrix tablets were prepared by direct compression method. The formula was com, Of various concentrations of natural gum in drug and polymers ratio 1:05, 1:1 and 115%, Various percentages. {The drug and excipients were weighed separately and passed through #100 mesh sieve, | Dig was added to the lactose and polymer mixture and then blended for 20 min Invitro Drug F * Atlast the lubricants were added and the mass was subjected to compression. | ee Assay Twenty tablets were weighed and powdered. A quantity of the powder equivalent to010ga | diclofenac sodium was weighed accurately and dissolved in 100 mi of phosphate buffer (pH68),_| Then, itis shaken for 15 min and filtered and 10m ofthe filtrate was diluted to 100 ml with phosphate Puffer (pH'68). The drug content was estimated UV spectrophotometrically at 283 nm, Preparation of Standard Solution RESULTS, A stock solution containing 1000 pg/ml of pure drug was prepared | weighed 100 mg of diclofenac sodium in 100 ml of further diluted to prepare 2 to 10 g/ml by dissolving accurately phosphate buffer. The stock solution was DIScuss| In Vitro Drug Release Study : / USP apparatus 2 (paddle type) was used, W ater was filled in dissolution apparatus tank uplo Specified level and the heater was switched on to maintain the temperature at 37£05°C. Ie dissolution medium consisted of 900 ml of standard buffer (pH 1.2) for 2 hrs, followed by pH 88 for remaining period of time. Then, the Speed of paddle was set at 50 rpm and time ofthe Pleed fa eas Set for 60 min. Diclofenac sodium tablets of different formulations were thet Placed in the vessels. A suitable volume of t intervals and the vessels were replenished with then diluted and the absorbance of the resultin, et 288)nm. The study was performed in triplicate.09S of Xanthan BM = on ffsodium aliginate gum = of Tablet Properties en ation, tibility, hardness, disintegration time and assay. ovis Curve of Diclofenac Sodium [Absorbance In Vitro Drug Release — ini) Absorbance Concentration oe ugh) A F; Fi | E, | RESULTS wd BLIOGRAPHY 1, Hingmi Hinge LP, a: Development and evaluation of sustained release matrix tablets using 2, fils modifier. Research} Pharm and Tech, 200813) Anil. Xanthan-A versatile gum. Resonanace; 2004: 25-33. oe