MODIFIABLE: NON- MODIFIABLE:

Geographical location Age

Medical condition
Seasons Vector mosquito bites
(Anopheles, Plasmodium
Falciparum) 

Enters directly into the blood

streams

Virus replication of dendritic

cells and macrophages in the
lymph nodes

Virus disseminates to the

parts of the body

cross the blood-brain barrier

and enters the neural
cells/brain cell

Immune system attacks both

infected and healthy cells in
the brain

Disrupt, damage and

raptures the brain cells and
functioning

Inflammation of the brain

Fever, temperature of
Bulging of the fontanelle Headache, Stiff neck,
39.8C
Sensitivity to light,
Depressed LOC.

Dehydration

Sunken eyes, Lethargy,

pale oral mucosa.