Professional Documents
Culture Documents
June ,2020
Bahirdar
7/10/2020 BY Berihun B. 1
Content outlines
Objectives
Introduction to fluid therapy
Evidence based fluid management for critically ill
patients
Evidence based electrolyte management for critically
ill patients
ICU management status in Ethiopia
Summary
References
Acknowledgement
7/10/2020 BY Berihun B. 2
Objectives of the lesson
Upon completion of this lesson , You the
students will able to
I. Mention the common fluid and electrolyte therapy for
critically ill patients
II. Analyze the cons and pros of different fluid and
electrolyte therapy for Critically ill patients Differentiate
staging and grading of cancers
III. Choose the recommended fluid therapy for the respective
patients in ICU.
IV. Improve their daily nursing practice on fluid and
electrolyte therapy by adopting evidence based findings .
7/10/2020 BY Berihun B. 3
Introduction to fluid and electrolyte therapy
Total volume of body fluids consists of 60% of
lean body weight in men 50% of lean body weight
in women.
Distribution of fluid in the body is:
1. 1/3 extracellular fluid
Interstitial fluid- 75-80%
Plasma or intravascular fluid- 20-25%
Trans cellular fluid
2. 2/3 intracellular fluid
Fluid within a cell
Red blood cells
Other cells
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Conti--
• Intravenous fluids are similarly classified based
on their ability to pass through barriers
separating body fluid compartments, i.e
intravascular and extravascular (interstitial)
fluid compartments
• In 1861 Thomas Graham’s investigated and
classified substances or fluids as crystalloids
and colloids depending on their ability to diffuse
through a parchment membrane
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Crystalloid fluids
• Crystalloid are electrolyte solutions with small molecules
that can diffuse freely from intravascular to interstitial fluid
compartments.
• Predominant effect of volume resuscitation with crystalloid
fluids is to expand the interstitial volume rather than the
plasma volume.
• Because of this, larger volumes of crystalloid than colloids
are required for fluid resuscitation and vascular expansion
( 3 l of NS needed for 1litter of vascular fluid loss )
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Conti-
• Crystalloids can be either
1. Hypertonic – draws fluid into the intravascular
compartment from the cells and the interstitial
compartments, results cellular shrink. It includes
Hypertonic saline ,10%, 25% & 50% dextrose, D 1/2 NS
2. Hypotonic- shifts fluid out of the intravascular
compartment, hydrating the cells .Eg- 0.45% Sodium
Chloride(1/2 NS)
3. Isotonic- 0.9 N/s , Lactated Ringer’s and Hartman's
solution, stays in the intravascular space and expands the
intravascular compartment.
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Common Crystalloids
Solution Uses Nursing considerations
Dextrose 5% in Fluid loss Use cautiously in renal and cardiac patients,
water(D5W) - Dehydration May cause hyperglycaemia or osmotic
Isotonic Hypernatremia diuresis, not used for shock
0.9% Sodium Shock ,Blood transfusions Can lead to overload, Use with caution in
Chloride Resuscitation and Preferred in patients with heart failure or oedema
(Normal saline case of brain injury, May produce a metabolic acidosis due to
( Isotonic) Fluid challenges, DKA/ initial/ hypercholermia ( 154meq/l)
Lactated Dehydration, Burns ,Lower GI Contains potassium, don’t use with renal
Ringer’s ( RL) fluid loss, pancreatitis failure patients, Don’t use with liver
( Isotonic) Acute blood loss, DKA disease/c they can’t metabolise lactate
Dextrose 10% Conditions where some Monitor blood sugar levels .
in water nutrition with glucose is uses for Water replacement
(hypertonic) required
Dextrose 5% in It is hypertonic solution used Use only when blood sugar falls below
½ NS Later in DKA 250mg/dl
0.45% (1/2) Water replacement, Na Excess Don’t use with liver disease, trauma or
NS ( DKA , Gastric fluid loss from burns, May cause cardiovascular collapse or
hypotonic NG or vomiting. increased intracranial pressure
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Colloids
• Colloid fluid is a saline fluid with large solute
molecules/proteins/ that do not readily pass from
plasma to interstitial fluid.
• They remain in blood vessels longer time , hence
increase intravascular volume 3 times more than
crystalloid with equal volume administered
• They attract water from the cells into the blood vessels
and can lead to cellular dehydration
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Common colloids
Types Action/use Nursing considerations
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Conti--
• Currently, normal saline is the most commonly used
resuscitation fluid. How ever, can lead to a
hyperchloremic metabolic acidosis which has been
associated with complications in some studies.(Yunos
NM, 2012., , Shaw AD, et al.2014 )
• These “balanced” solutions are not universally
available and can be significantly more costly than
0.9% normal saline solution which are major criteria's
for choosing fluid
• Hence choosing the better is controversial overtime.
7/10/2020 BY Berihun B. 15
Conti--
• Some observational studies, clinical trials and meta
analysis suggest the use balanced crystalloid use is
associated with lower risk patient outcomes such as
acute kidney injury/AKI/ and death in critically ill
patients.(Semler et al. 2019)(Liu et al., 2018)
• Current evidences from meta analysis studies shows
no clinically statistical significant difference
In the length of in hospital stay ,
Incidence acute kidney injury, or
organ-system dysfunction and rate of death
between 0.9% normal saline solution and balanced
crystalloid solutions(((Zhou et al., 2018,Liu et al., 2019,
Xu et al., 2020,Antequera Martín et al., 2019)
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Conti– 5, 10 , 25,40 %Dextrose
Many disadvantages in critically ill pts. like
increase lactate production due to impairment of cellular
glucose utilization leads to cellular dehydration
Aggravate Ischemic brain injury and
increase risk of infection,
• combined with a lack of documented benefit, the
recommendation is that the routine use of 5% and other
dextrose infusions be abandoned in critically ill patients,
especially for resuscitation .(Finney et al , 2003)
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Colloids For ICU patients
7/10/2020 BY Berihun B. 18
Conti-- Albumin
• Albumin -is the only natural colloid used for intravascular
volume replacement in humans.
• Overall, albumin is equivalent to saline for fluid
resuscitation of critically ill patients ,but could have
beneficial effects in patients with sepsis and those with
spontaneous bacterial peritonitis etc (Finfer et al., 2018)
• Given the cost of human albumin, it should generally not be
considered the first choice for fluid replacement unless
there is a specific indication ( cirrhosis and liver
transplantation, SBP ) for its use ((Martin et al., 2018).
7/10/2020 BY Berihun B. 19
Cont---
• Albumin increases mortality in traumatic brain injury
7/10/2020 BY Berihun B. 20
Fluid Administration in Specific Disease Conditions
7/10/2020 BY Berihun B. 21
Fluid for sepsis
• Aggressive volume resuscitation is the best initial
therapy for the cardiovascular instability of sepsis
• Even though intravenous administration of 0.9% saline
may cause hyperchlorema acidosis no significant
difference b/n balanced and NS crystalloids on rates
of mortality and AKI of sepsis patients ((Gottlieb et
al., 2020)
• Hence 0.9% saline remains the treatment of choice
for hemodynamic ally unstable septic patients .
7/10/2020 BY Berihun B. 22
Conti– protocol of management
7/10/2020 BY Berihun B. 24
Fluid therapy for Adult Respiratory Distress
Syndrome/ARDS/
• ARDS was initially considered an inflammatory protein-
rich pulmonary edema accompanied by leakage of
protein-rich fluids into the interstitial space
• ARDS has both inflammatory edema and hydrostatic
components due to pulmonary hypertension
• Conservative( not liberal) fluid management decreases
hydrostatic pressure and increase serum oncotic pressure
,potentially limiting the development of pulmonary
edeoma leads better oxygenation and shorter periods of
mechanical ventilation ((Martin et al., 2018,((Silversides
et al., 2019))
7/10/2020 BY Berihun B. 25
Conti--
• Three main areas of conservative management
1. Restrictive use of fluid, together with earlier use of
vasopressor
2. De- resuscitation- defined as active fluid removal
using diuretics after resuscitation if CVP > 8 mmhg
or CVP 4-8 plus UOP >0.5ml/kghr
3. Taking into account the etiologies(burns, TBI,
infection) , patient conditions and hemodynamic
status to predict who will benefit and who .not
7/10/2020 BY Berihun B. 26
Fluid for Major Abdominal Surgery
• Fluid administration is part of the perioperative routine
in both elective and urgent major abdominal surgery .
• Adequate preoperative preparation for elective major
abdominal surgery should not induce a fluid deficit
exceeding 2.5% of body weight.((Martin et al., 2018)
• Intraoperative/postoperative rehydration of elective
cases should be performed with a balanced salt
solution
• The principles guiding fluid administration in sepsis
should also guide perioperative fluid administration in
patients undergoing urgent abdominal surgery.
7/10/2020 BY Berihun B. 27
Conti--
• The crystalloid chosen for patients after urgent
abdominal surgery should be determined individuals
status after arrival on Intensive care unit.((Martin et
al., 2018)
• Colloids may be administered in elective surgery
cases if required.
7/10/2020 BY Berihun B. 28
Fluid management for trauma patients
• In the hypotensive trauma patient, crystalloids should
be administered initially and the amount of fluids
administered should be restricted
• Balanced crystalloids are preferred over normal saline
for large volume resuscitation of trauma patients .
(Martin et al., 2018)
• Colloids and hypertonic solutions can not be used as
first line therapy even if they accelerate hemodynamic
goals .(Liu et al., 2019)
• Albumin and hypotonic saline should not be
administered to patients with TBI.
7/10/2020 BY Berihun B. 29
Fluid therapy for AKI patients
• Fluid administration is one of the cornerstones of
prevention of AKI.
• Regarding to the cause and/or mechanism of AKI ,
decrease tissue perfusion as in case of hemorrhagic
shock, endothelial dysfunction, local and systemic
inflammatory processes and oxidative stress in case of
sepsis are the major contributing factors
7/10/2020 BY Berihun B. 30
Conti– AKI
• If a large volume of fluid is likely to be required for
resuscitation, especially in septic patients, balanced
fluid solutions should be selected as these may
reduce the likelihood of AKI.
• Normal saline 0.9% remains useful for patients with
hypochloremic alkalosis
• Administration of HES increases the incidence of
AKI and RRT in critically ill patients ,the use of HES
is therefore no longer approved for these patients
regardless of cause of admission.((Finfer et al.,
2018)
7/10/2020 BY Berihun B. 31
Electrolyte management for critically ill patient
7/10/2020 BY Berihun B. 32
Hyponatremia management
• It has been observed in 14% of patients upon
admission to the ICU
• Occurs as a result relative water excess in
conjunction with impaired ability of the kidney to
excrete electrolyte-free water due to SIADH, disease
like Heart failure, sepsis and shock
• Symptoms of hyponatremia such as orthostatic
hypotension, poor mental status, dry oral mucos and
altered mental status, occur most commonly with a
rapid decrease in plasma [Na+] to < 125 mEq/L.
7/10/2020 BY Berihun B. 33
Conti--
7/10/2020 BY Berihun B. 34
Hypernatremia management
• Patients in the ICU are at a high risk of developing
hypernatremia due to
1. Administration of sodium bicarbonate solutions to
correct metabolic acidosis;
2. Renal water loss through a concentrating defect from
renal disease
3. Gastrointestinal fluid losses through nasogastric
suction and lactulose administration
4. water losses through fever, drainages, and open
wounds
7/10/2020 BY Berihun B. 35
Conti- Management
7/10/2020 BY Berihun B. 36
Hypocalcaemia management
7/10/2020 BY Berihun B. 38
Hypomagnesaemia management
• Hypomagnesaemia is frequently observed in critically
ill patients, and its prevalence in the ICU is reported
to be as high as 50%.((Limaye et al., 2011)
• Excess gastrointestinal or renal losses, surgery,
trauma, infection or sepsis, burns,, alcoholism,
starvation or malnutrition and diuretics are the most
common causes
• Severe hypomagnesaemia can result in
electrocardiographic changes, arrhythmias , comma
and death
7/10/2020 BY Berihun B. 39
Conti--
• Goal of therapy to maintain serum Mg++ b/n 1.5- 2.4
mg/dl , resolve symptoms and avoid hypomagnesaemia
• Intravenous administration of magnesium sulfate is
preferred in critically ill patients with severe (plasma
[Mg2+] < 1 mg/dL) or symptomatic hypomagnesaemia
• Since it distributes slowly and renal excretion is low
,doses less than 6 g of magnesium sulfate are infused
over 8-12 hours, and higher doses are given over 24
hours ((Latcha , 2015)
7/10/2020 BY Berihun B. 40
Hyperkalemia management
• Renal failure, adrenal insufficiency, insulin deficiency
and resistance, medications ( B-blockers, RAAS
inhibitors, NSAID) predisposes to hyperkalemia
• Treatment strategy of hyperkalemia depends on the
presence of emergent signs like ventricular tachycardia
shown in ECG.
• Intravenous calcium gluconate is the first step of
management to antagonize the depolarizing effect of
hyperkalemia
• The next step should be to facilitate the shift of
potassium into intracellular compartment (Insulin with
50% glucose is most effective ) (Weisberg, 2008)
7/10/2020 BY Berihun B. 41
Hypokalemia management
• Major causes of hypokalemia include
1. Medications like sympathomimetic, insulin,
methylxanthines, and dobutamine commonly
prescribed in the ICU are associated with
hypokalemia
2. Low dietary potassium intake and diuretics
The most dreaded complications related to
hypokalemia are cardiac arrhythmias, especially in
patients with hypertension, myocardial
infarction/ischemia, or heart failure.
7/10/2020 BY Berihun B.
Conti-
• Except for emergent settings, oral administration of
potassium is always preferred
• Rapid infusion of potassium for emergent conditions
(i.e., > 10-20 mEq/hr) requires a central venous catheter,
as infusion via a peripheral line causes phlebitis and vein
injury.
• Amount of the initial dose should be in the range of 40-
80 mEq.
• Total amount of daily K+ replacement should be less than
240-400 mEq/day and it should be added dextrose free
solutions
7/10/2020 BY Berihun B. 43
ICU management practice in Ethiopia
• ICU mortality rate was 50.4% and major causes included
trauma, cardiac disease, acute abdominal presentations,
septic shock (Smith et al., 2013)
• KAP of nurses on ICU management is poor
(Dereje.N , 2108)
• Prevalence of medication administration errors
predominantly fluid errors in the ICU of JUSH (51.8%).
- wrong timing administration (30.3%)
-omission due to unavailability (29.0%)
and missed doses (18.3%) among others occurs due to
lack of trained nurses and close supervision.((Agalu et al.,
2012)
7/10/2020 BY Berihun B. 44
Nursing diagnosis
7/10/2020 BY Berihun B. 45
Summary
• Intravenous fluid therapy is one of the most common
interventions in acutely ill patients.
• Crystalloid commonly normal saline is the most
commonly used resuscitation solution with no
significant difference.
• Even if colloids achieve hemodynamic goals early , they
are not first line management for fluid therapy and
they may be added for sepsis and shock if unresponsive
for crystalloid
• Hypocalcaemia, hypomagnesia , hypo/ hyperkalemia ,
hypo/ hypernatrmia are common electrolyte disorders
occurred on ICU patients
7/10/2020 BY Berihun B. 46
References
1. Anders Perner, P.B.H., et.al , Focus ( 2019): On FluidTherapyInCritically ill
patients Springer, p. 1-3.
2. Antequera Martín, A.M., et al (2019)., Buffered solutions versus 0.9% saline
for resuscitation in critically ill adults and children. Cochrane Database Syst
Rev,. 7(7): p. Cd012247.
3. Casey, J.D., R.M. Brown et.al (2018), Resuscitation fluids. Curr Opin Crit
Care,. 24(6): p. 512-518.
4. Freeman, L., et al(2019:), Assessment of Electrolyte Replacement in Critically
Ill Patients During a Drug Shortage. Hospital Pharmacy:
p.0018578719893375
5. Gottlieb, M., V. et.al (2020). , Are Balanced Crystalloid Solutions Better Than
Normal Saline Solution for the Resuscitation of Children and Adult Patients?
Ann Emerg Med, 75(4): p. 532-534.
6. Keddissi, J.I., et al ( 2019) ., Fluid management in Acute Respiratory Distress
Syndrome: A narrative review. Canadian journal of respiratory therapy:
CJRT= Revue canadienne de la therapie respiratoire: RCTR, 55:
7. Atcha, S et atl (2014,) Electrolyte Disorders in Critically Ill Patients, in Critical
Care,., McGraw-Hill Education: New York, NY.
7/10/2020 BY Berihun B. 47
Conti--
8. Martin, G.S. and P. Bassett, Crystalloids vs. colloids for fluid
resuscitation in the Intensive Care Unit: A systematic review and
meta-analysis. Journal of critical care, 2019. 50: p. 144-154.
9. Semler, M.W. and J.A. Kellum, Balanced Crystalloid Solutions. Am
J Respir Crit Care Med, 2019. 199(8): p. 952-960.
10. Shin, C.H., et al., Effects of intraoperative fluid management on
postoperative outcomes: a hospital registry study. Annals of
surgery, 2018. 267(6): p. 1084-1092.
11. Silversides, J.A., A. Perner, and M.L. Malbrain, Liberal versus
restrictive fluid therapy in critically ill patients. Intensive care
medicine, 2019. 45(10): p. 1440-1442.
12. vincent, J.-L., Fluid management in the critically ill. Kidney
international, 2019.
13. Wang, A.S., et al., The Impact of IV Electrolyte Replacement on
the Fluid Balance of Critically Ill Surgical Patients. Am Surg, 2019.
85(10): p. 1171-1174.
7/10/2020 BY Berihun B. 48
Acknowledgment
• My deepest gratitude and appreciation goes to our
instructor Mr Awol.(Asst professor,) and Mr Yeshaneh
(Asst professor )for offering this assignment which
enforces me to explore different literature's related on
fluid and electrolyte management for critically ill patients
and to have better know how on it.
• Secondly I would like to express my heartfelt thanks to
Bahirdar University College of medicine and Health
science for Initiating and cascading virtual learning
during corona pandemic so that we will manage our time
properly.
7/10/2020 BY Berihun B. 49
STAY SAFE !!!
7/10/2020 BY Berihun B. 50