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  • Barbiturates by GC - MS HPLC and Chemical Ionization

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    Abdulaziz
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    Barbiturates are central nervous system depressants that are commonly used as sedatives or anesthetics. Their usage has increased as a way to relieve stress. However, overuse can lead to death. The document describes a method for analyzing different barbiturates like phenobarbital and pentobarbital using gas chromatography-mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC) to separate and identify the barbiturates in a mixture and determine the lowest concentration that separation can be achieved.

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    analysis of barbiturate

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    Barbiturates by GC_MS HPLC and Chemical Ionization

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    Barbiturates are central nervous system depressants that are commonly used as sedatives or anesthetics. Their usage has increased as a way to relieve stress. However, overuse can lead to death. The document describes a method for analyzing different barbiturates like phenobarbital and pentobarbital using gas chromatography-mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC) to separate and identify the barbiturates in a mixture and determine the lowest concentration that separation can be achieved.

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    © All Rights Reserved
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    10 views4 pages

    Barbiturates by GC - MS HPLC and Chemical Ionization

    Uploaded by

    Abdulaziz
    Barbiturates are central nervous system depressants that are commonly used as sedatives or anesthetics. Their usage has increased as a way to relieve stress. However, overuse can lead to death. The document describes a method for analyzing different barbiturates like phenobarbital and pentobarbital using gas chromatography-mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC) to separate and identify the barbiturates in a mixture and determine the lowest concentration that separation can be achieved.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
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    Analysis of Barbiturates by GC/MS,

    HPLC
    INTRODUCTION:

    Barbiturates are derivatives of barbituric acid. They act as central nervous depressants. These
    drugs are frequently used as sedatives or anesthetics. It is a simple and reproducible method for
    the analysis of barbiturates.

    Usage of these drugs is increased in recent days and the analysis of barbiturates by GC/MS is
    very fast. As they are used as sedatives their usage has been increased to relieve the stress. But
    the over usage of these drugs may lead to death. Different barbiturates like phenobarbital,
    pentobarbital can be analyzed by their molecular weights. Because of the over usage of the drugs
    the interest to analyze them has been enhanced in order to know the characteristics.

    Barbiturates are intially derived from urea.

    Barbiturate mixture contains different barbiturates such as Amobarbital, Pentobarbital,


    Butabarbital, Phenobarbital, Secobarbital. By using their CAS numbers and
    search their molecular weights and structures were from the library

    Separation and analysis of barbiturates from mixture is done bye using GC/MS. The sample is
    also run through HPLC to know the least concentration at which the separation can be done.

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