Kaposi’s Sarcoma Kaposi’s sarcoma (KS)

is the most common HIV-related malignancy and involves the endothelial layer of blood and lymphatic
vessels. In people with AIDS, epidemic KS is most often seen among male homosexuals and bisexuals.
AIDSrelated KS exhibits a variable and aggressive course, ranging from localized cutaneous lesions to
disseminated disease involving multiple organ systems. Clinical Manifestations • Cutaneous lesions can
occur anywhere on the body and are usually brownish pink to deep purple. They characteristically
present as lower-extremity skin lesions. • Lesions may be flat or raised and surrounded by ecchymosis
and edema; they develop rapidly and cause extensive disfigurement. • The location and size of the
lesions can lead to venous stasis, lymphedema, and pain. Common sites of visceral involvement include
the lymph nodes, gastrointestinal tract, and lungs. • Involvement of internal organs may eventually lead
to organ failure, hemorrhage, infection, and death. Assessment and Diagnostic Findings • Diagnosis is
confirmed by biopsy of suspected lesions. • Prognosis depends on extent of tumor, presence of other
symptoms of HIV infection, and the CD4count. • Pathologic findings indicate that death occurs from
tumor progression, but more often from other complications of HIV infection