‘The correctansweris [439] ‘step 1 Disease Diagnose ‘Thisptin ihely has primary antiphospholipid antibody syndrome?) based an ecient venous thrmboes(hypetcoagulabity), frequent micaisges thrombocytopenia and fase postive rape plasma reagin test APS may be associated with systemic pus erythematosus [SLE] rather autoimmune dsase. However APS isnot associated wth these zor i, primary) approximately 5% of heme. Tent 15% of patents ith APS wl ter develop SLE Patients have recurent venous or atria bol including deep venous \tromboses and pulmonary emboli strokes, and recurrent miscarriages. Thrombocytopenia and hypocomplementamia may be seen ith or without SLE, ‘step 2: Diagnostic Testing ‘05 patents hav prolonged partial thromboplastin ime P17. PTTkpolonged because the autoantibodies bind othe phosphalipd reagent usedinthe PT test nacthating and falsely prolonging the PT. This permanent binding and PTT prolongation isnot corrected by mixing 1:1 with fresh frozen plasma, Corecton ofan eeited PTT would be seen in clotting ator deficences. APS is more dec diagnosed by detecting speci serum autoantibodies (eg. antcardoipn or an-beto-2ycapoti) The false-positive rapid plasma reagintest result occurs because the reagent useinthe test contain cadoliin, which eat with the patents autoantibodies The other choices areinconect + Prolonged partial thromboplastin time thats corrected by mixing i: with fresh frozen plasma would be senin a patint wth loting factor efiiency nthisseting, ining with rsh rote plasma would epace he factor thatthe patients missing, and the PTT woul be corete, + Decreased partial thromboplastin time thats corrected by mixing or without mixing I: with fresh frozen plasma ros fen relets poor sample colecton or preparation uti eccasional seen in patients ith malignancy lsseminatd inauascular cogulaton or ater eerie