‘Acta Biol Par, Curitiba, 27 (1,2,3,4):97-108, 1998
Proteolytic effect of Loxosceles intermedia
(brown spider) venom proteins on EHS-basement
membrane structures
Efeito proteolitico do veneno de
Loxosceles intermedia (aranha marrom) sobre
estruturas da membrana basal de EHS
G. A. ve Souza
A.S. RIBEIRO.
V.L.P. Santos
S. 8. Veica |
0..C. Manan?
Ano W. GREMskt !
Loxoscelism is mainly characterized by two typical clinical signals,
i.e.,adermonecrotic lesion and systemic effects. The dermonecrotic
lesions appear at the bite site, with erytherna, edema, and a local dermal
haemorshage, that can evolve to the formation of necrotic sore of diffi-
cult civatrization with degenerative implications for the affected tissue
(Forrester, BaRRet & Campori, 1978; FUrRELL, 1992). Systemic
effects are characterized by fever, malaise and bleeding that can evolve
(hemolysis, thrombocytopenia, disseminated intravascular coagula-
tion, and renal failure (Kuretewsxt et al., 1981; Bascur, Yevenes &
Boacia, 1982; Rees eral., 1988; Taisourct er al., 1995).
"ixparanent of Cal Biology, Federal Univers of Patan, Jaro dap Amésiss, 8153-990,
Cotina Paans, raz, ?Depantroet of Physiology, Federal Univesity of Pusan Cori,
Braid Tu whom eosterpondence should be addeeised. FAX: ODSS41-266-2049. E mall:
sot Tee. om. be % Acta Biol, Par, Cuitiba, 27 1,2, 3,4: 97-109. 1998,
Dermonecrotic Fesions, thrombocytopenic activity, disseminated in-
avascular coagulation and renal failure are events that could be as-
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