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Pain Medicine 2017; 0: 1–11

doi: 10.1093/pm/pnx134

Original Research Article


Acupuncture Therapy in a Group Setting for
Chronic Pain

Benjamin Kligler, MD, MPH,* Arya Nielsen, PhD,*,† established in a two- to four-week run-in; assess-
Corinne Kohrrer, LAc, FNP,†,‡ Tracy Schmid, LAc,† ment of the intervention impact on pain intensity,
Eve Waltermaurer, PhD,* Elidania Perez, MS,*,† and mood, and functional status were made at the end
Woodson Merrell, MD† of the treatment period (eight weeks) and 16 weeks
after completion of intervention (24 weeks).
*Department of Family Medicine, Icahn School of
Medicine at Mount Sinai, New York, New York; †Mount Results. Of the total 113 participants recruited for
Sinai Beth Israel Medical Center, New York, New the trial, 96 completed the 24-week protocol. We
York; ‡Hunter-Bellevue School of Nursing, New York, found a statistically and clinically significant de-
New York, USA crease in pain severity, pain interference, and de-
pression in our study population. There were no
Correspondence to: Benjamin Kligler, MD, MPH, 421 serious adverse events.
Fifth Street, Brooklyn, NY 11215, USA. Tel:
2028219142; E-mail: benkligler@gmail.com. Conclusions. Acupuncture therapy offered in the
group setting was effective in reducing pain sever-
Funding sources: This project was supported by a
ity, pain interference, and depression in patients
grant from the Blavatnik Family Foundation (52404029). with chronic neck, back, or shoulder pain or osteo-
Disclosure and conflicts of interest: None of the arthritis. Benefit persisted through the 24-week
authors had any conflicts of interest, and the funding measure despite no additional treatment. This find-
foundation had no input into study design or the ing has potentially important implications for im-
proving access to effective acupuncture treatment
analysis or reporting of results.
for patients with limited financial resources.

Key Words. Acupuncture, chronic pain, comple-


Abstract mentary medicine

Objective. This project was designed to test the fea-


sibility and effectiveness of acupuncture therapy Background
given in a group setting for chronic pain.
The prevalence of chronic pain problems in the general
Design. Nonrandomized, repeated measures quasi- adult US population is high; estimates have ranged from
experimental trial. 10% to 40% in recent large surveys depending on the
specific sample [1–4]. Research has also documented a
Setting. Care was delivered in a primary care clinic
positive association between pain and impairment in
waiting area after clinic hours.
physical and psychological functioning [5,6], lost work
productivity [7], and lower socioeconomic status [8].
Subjects. Included were primary care patients
There is substantial evidence that minority and poor
(18 years old) with chronic pain of the neck, back, populations differ both in the prevalence and outcomes
shoulder, or osteoarthritis of any site of at least of chronic pain [2,8–11]. In addition, race/ethnicity and
three months’ duration. socioeconomic factors influence access to pain care
[10,12–14].
Methods. Subjects received eight weekly acupunc-
ture therapy sessions in a group setting. A great deal of evidence now supports the use of acu-
Acupuncture therapy included a combination of pal- puncture therapy in the treatment of chronic pain condi-
pation, acupuncture needling, Tui na, Gua sha, and tions [15,16], including shoulder pain [17,18],
auricular treatment. Baseline pain levels were osteoarthritis [19–23], neck pain [24–26], and low back

C 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
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Kligler et al.

pain [26–28]. Acupuncture is recommended as a firstline have not received acupuncture treatment within the
treatment by the American College of Physicians in their past three months, and 5) have no severe psychiatric
2017 Clinical Practice Guidelines for acute and chronic problems that could interfere with the ability to receive
low back pain and by the National Institutes of Health treatment in a group setting.
for low back pain and knee osteoarthritis [29,30].
Although the mechanism of action remains complex
Design
and some studies find both “sham” (needles in nonacu-
puncture points) and real acupuncture to be effective,
The study used a repeated measures quasi-
studies also show that 40% to 50% of patients experi-
experimental design. The multiple pretreatment mea-
ence a reduction in pain with acupuncture treatment
surement points during the run-in period allowed us to
with some evidence of persistence in pain reduction in
document and monitor the typically variable patterns of
the long term from real acupuncture [31].
pain pre-intervention. This design optimized feasibility
and acceptability to patients and participating health
Most acupuncture therapy is delivered in individual
centers while still generating meaningful outcome data.
practitioner-patient sessions. Patients from lower socio-
Specifically, we did not propose randomization within
economic groups are generally not able to access acu-
the practices, rather allowing clinicians to offer the inter-
puncture treatment in the United States; services are
vention to all patients with target diagnoses who meet
not generally reimbursed by insurers, and patients often
eligibility criteria.
cannot afford the out-of-pocket expense. Therefore,
cost and access pose a major barrier to widespread im-
plementation in this patient population. Acupuncture Intervention
care delivered in a group or community setting has
been shown to be feasible for patients with chronic pain The intervention consisted of eight weekly sessions of
including patients from lower socioeconomic groups acupuncture therapy in a group setting provided by li-
[32–34]. There is some evidence of effectiveness of acu- censed acupuncturists. Appointments were staggered
puncture therapy in groups for knee osteoarthritis [35] every 15 minutes; each subject was present for 40 to
and peripheral neuropathy [36,37], but other chronic 60 minutes total, with the treatment lasting from 20 to
pain conditions have not been studied in a group set- 40 minutes. Group sessions were scheduled to accom-
ting. Formalized auricular acupuncture given in a group modate up to eight subjects per session. Sessions were
setting has been used extensively in the treatment of conducted in the late afternoon and evening by the
substance abuse disorders [38,39]. This project was de- same acupuncturist; the study care was delivered by
signed to test the feasibility and effectiveness of group two acupuncturists (CK and TS), each with over
acupuncture for the treatment of back pain, shoulder 10 years’ clinical experience. Study sessions were often
pain, neck pain, and osteoarthritis. The goal of this proj- assisted by a student acupuncturist or additional acu-
ect was to develop and pilot a low-cost, effective inte- puncturist who helped greet patients but was not di-
grative intervention for chronic pain that, if found to be rectly involved in patient care.
effective, could be replicated easily in underserved set-
tings across the United States. Our intervention manual was developed using a modi-
fied Delphi process over two months with a team of
Methods acupuncturists experienced in individual and group acu-
puncture care for chronic pain including current and for-
Setting and Subjects mer fellows of the Acupuncture Fellowship for Inpatient
Care at Mount Sinai Beth Israel. Participants had trained
This study was approved by the Icahn School of in the United States, China, and Vietnam. Our approach
Medicine at Mount Sinai Institutional Review Board. We consisted of real-world acupuncture therapy options
recruited outpatients with chronic pain from local pri- and combinations: assessment, palpation, Tui Na, Gua
mary care practices in New York City. Chronic pain was sha, acupuncture needling, auricular treatment, and
defined as pain that persisted for at least three months’ simple diet and lifestyle recommendations based in tra-
duration. After a two- to four-week run-in period to es- ditional East Asian medicine allowing treatment to be
tablish average baseline pain levels, participants were shaped to individual patients’ needs through time.
offered an eight-week, group-based acupuncture treat- Common points were needled based on the patient’s
ment intervention. We evaluated the impact of this inter- presentation, with optional points selected based on
vention on pain intensity, mood, and functional status, palpation of channels. Points were needled to obtain
as well as the effects on analgesic use. Patients age “de qi,” which can be felt by the patient and practi-
18 years or older were eligible to participate in this study tioner, sometimes with fasciculation and/or a grabbing
if they had chronic pain due to a qualifying diagnosis of of the needle as it is manipulated, representing fibril
back pain, shoulder pain, neck pain, and/or osteoarthri- “whorling” within the connective tissue and mechanical
tis. In addition, participants had to 1) understand propagation of the signal along channels or connective
English 2) be able to provide phone numbers to facilitate tissue planes. Noncoated acupuncture needles were
scheduling, 3) be available for up to eight weekly treat- used to maximize the connective tissue response and
ments and 16 weeks of follow-up post-treatment, 4) analgesic effect [40–44].

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Acupuncture Therapy in a Group Setting for Chronic Pain

Non-needling techniques were also used in the ap- Table 1 Data collection
proach, including Tui Na, manual therapy often used in
conjunction with acupuncture, particularly for muscle Pre Week Week Week Week
and joint pain, and Gua sha, defined as instrument- Measure Baseline 1 1 8 12 24
assisted closely timed unidirectional press-stroking of a
lubricated area of the body surface to intentionally create BPI X X X X X X
transitory therapeutic petechiae called “sha,” represent- CES-D X X X X X
ing extravasation of blood in the subcutis [45]. In Tui Na, Pain-free days X X X X X X
specific applications are used to stimulate, relax, warm, PGIC X X X
and irrigate channels in or associated with painful areas Demographics X
[46]. In traditional East Asian medicine, acupuncture Medication use X X X X
channels or meridians represent both the vertical and
horizontal pathways connecting the surface of the body BPI ¼ Brief Pain Inventory–Short Form; CES-D ¼ Center for
to internal tissues and organs. Acupuncture channels Epidemiological Studies–Depression Scale; Pre ¼ pre-acu-
and points have more recently been associated with puncture; Week 1 ¼ first acupuncture visit.
connective tissue planes [44], and their stimulation to a
global physiologic network [47]. Tui Na can be especially
useful if the subject is new to acupuncture therapy and/ examined medication utilization, asking participants at
or has a fear of needles. Gua sha is used to resolve the baseline and week 1, week 8, and week 24 to report
condition known as “blood stasis” in Chinese medicine, their use of pain medications over the prior two-week
which is associated with persistent, fixed, or recurring period. Measures were collected over the 24-week
pain. Gua sha mechanically stretches the subcutaneous study period as per the schedule in Table 1.
fascia, and the production and resolution of “sha pete-
chiae” upregulates heme oxygenase-1 (HO-1), producing Analysis
an anti-inflammatory and immune protective effect locally
and systemically over a period of days following treat- Pain severity was measured using four BPI questions re-
ment [26,48–50]. Gua sha was delivered using single- lated to worst, least, average, and current pain. Each
use disposable metal caps [51] and a plain nonmedi- question was scaled from 0 (no pain) to 10; the answers
cated balm. Auricular treatment included ear needling were summed to form the scale pain severity measure.
and pressure applied to points on the ear with pretaped The multiple baseline (pre-intervention) measures were
seeds or sphere magnets retained between sessions. averaged for a single baseline measure. Pain
Auricular therapy has been shown to be an effective interference was measured using four BPI questions re-
treatment for acute and chronic pain [52,53]. lated to worst, least, average, and current pain. Each
question was scaled from 0 (no pain) to 10, and these
We instructed patients to arrive for treatment hydrated were summed to form the scale pain interference mea-
and having eaten something within the last hour to re- sure. The multiple baseline (pre-intervention) measures
duce the incidence of presyncope. We asked patients were averaged for a single baseline measure. For the
to wear loose clothing so that the neck, shoulders, up- BPI, we also measured percent change from baseline to
per back, forearms, and forelegs were accessible to 24 weeks to identify those with at least a 30% change
touch. Our sessions were conducted in a comfortable over that period. Depression was measured as the sum
clinic waiting area after clinic hours. Patients were either of the 20 CES-D questions (scored 0–10).
seated in soft chairs or on a couch.
Sociodemographic factors and baseline health indica-
Data Collection tors were examined comparing those patients who
completed the 24-week follow-up (N ¼ 96) with those
We had two primary outcome measures. The Brief Pain who initiated treatment but either withdrew from or were
Inventory–Short Form (BPI) [54] is a nine-item measure lost to follow-up (N ¼ 9) using the Fisher exact test for
that asks patients to indicate, over the past 24 hours, proportion and t test to compare means. Patients who
the level of pain they are feeling, the intensity of pain, enrolled in the study but never initiated treatment were
and how their pain influences select aspects of their ev- omitted entirely from the analysis (N ¼ 8). To compare
eryday life, that is, mood, walking, sleep, and their ability average pain severity, pain interference, and depression
to work. The Center for Epidemiological Studies– scores over time, repeated measures GLM were used
Depression Scale (CES-D) [55] is a well-validated, applying a Greenhouse-Geisser correction when the
20-item measure of depressive symptoms. Secondary spherocity assumption was violated by the data.
outcome measures included the Patient Global Additionally, baseline and 24-week outcomes were
Impression of Change (PGIC), a single-question seven- compared using repeated measures t tests. Data were
point categorical scale that captures a patient’s experi- entered, coded, and analyzed in SPSS v. 24. As there
ence of treatment at baseline and follow-up points and were no statistically significant differences between the
pain-free days, a self-report measure used in previous eight- and 12-week outcomes on any of the measures,
pain research. Patients were asked to report the number we have presented the data as baseline, midpoint, and
of pain free days in the previous two weeks. We also end point to maximize the number of patients included

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Kligler et al.

Table 2 Study demographics

Completed (N ¼ 96) LTFU (N ¼ 9) P


No. (%) No. (%)

Ethnicity Hispanic 25 (26.0) 2 (22.2) 1.00


Non-Hispanic 70 (72.9) 7 (77.8)
Missing 1 (0.1) 0 (0.0)
Race Asian 8 (8.3) 1 (11.1) 0.41
Black/African American 13 (13.5) 3 (33.3)
Other 18 (18.7) 1 (11.1)
White 53 (55.2) 4 (44.4)
Missing 4 (4.2) 0 (0.0)
Education Did not graduate high school 2 (2.1) 0 (0.0) 0.62
High school graduate 6 (6.3) 1 (11.1)
Some college 16 (16.7) 2 (22.2)
College graduate or greater 71 (74.0) 6 (66.7)
Missing 1 (1.0) 0 (0.0)
Work status Full time 56 (58.3) 6 (66.7) 0.37
Part time 9 (9.4) 0 (0.0)
Retired 17 (17.7) 0 (0.0)
Student 2 (2.1) 0 (0.0)
Disabled 4 (4.2) 1 (11.1)
Unemployed 5 (5.2) 1 (11.1)
Missing 3 (3.1) 1 (11.1)
Income <$20,000 10 (10.4) 2 (22.2) 0.86
$20,000–$49,000 26 (27.0) 1(11.1)
$50,000þ 45 (46.9) 5 (55.6)
Don’t know/refused/missing 15 (15.6) 1 (11.1)
Receiving routine medical care Yes 85 (88.5) 9 (100.0) 0.59
No 11 (11.5) 0 (0.0)
Insurance type Private 57 (59.4) 7 (77.8) 0.77
Fee-for-service 1 (1.0) 0 (0.0)
Medicaid 12 (12.5) 0 (0.0)
Medicare 17 (17.7) 2 (22.2)
N/A or missing 9 (9.4) 0 (0.0)
Disability Yes 6 (6.3) 1 (11.1) 0.48
No 89 (92.7) 8 (88.9)
Missing 1 (1.0) 0 (0.0)
Mean (SD) Mean (SD)
Age, years 54.0 (15.5) 44.7 (12.8) 0.09
Baseline pain severity 5.0 (1.7) 5.3 (2.0) 0.59
Baseline pain interference 3.7 (2.1) 4.7 (2.1) 0.13
Baseline 2-week pain-free days 1.5 (2.1) 1.7 (3.5) 0.75
Baseline depression 13.7 (9.0) 17.6 (12.2) 0.23

LTFU ¼ Lost to Follow Up.

in the analysis. For subjects (N ¼ 85) who had both patients never initiated the study intervention. Of the re-
eight- and 12-week data, we averaged the values for maining nine subjects, two patients withdrew, one pa-
analysis. To compare self-reported past two-week pain tient moved away after three sessions, one had surgery
medication use from baseline to eight weeks and base- and could not complete the study, and five could not
line to 24-week post-treatment, we used Pearson’s chi- be reached for the 24-week follow-up. Our average age
square test of proportions. was 54.4 years, and the ethnic makeup of our study
sample was representative of the New York City popula-
Results tion. There were no significant differences between
study completers and noncompleters in any category,
We recruited a total of 113 participants for the trial, 96 including pain severity or depression at baseline. The
of whom completed the 24-week protocol. Eight majority of our participants were insured, with 30.6% of

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Acupuncture Therapy in a Group Setting for Chronic Pain

those on Medicaid or Medicare. Outcome results below measured by the CES-D. The mean score at baseline
represent the 96 study participants who completed the was 13.47 (95% CI ¼ 11.67–15.27) as compared with
24-week term of the trial. Demographics for the two 9.79 (95% CI ¼ 7.61–11.97; P < 0.01) at 24 weeks. The
groups are presented in Table 2. clinical significance of this change is less clear than with
the pain measure as a cutoff of 16 on the CES-D is
We had complete data on a total of 95 subjects on pain usually used as a threshold indicating a risk for clinical
severity, 94 on pain interference, and 95 on the depres- depression. As with the pain measures, the benefit in
sion outcome. Using the generally accepted definition of depression was maintained through the 24-week end
a clinically significant change in pain being a 30% de- point despite the fact that no additional treatment was
crease from baseline, we found a statistically and clini- offered after week 8. Depression results are shown in
cally significant decrease in both pain severity and pain Figure 4.
interference in our study population. This difference not
only persisted beyond the eight-week end-of-treatment The PGIC measure decreased over the study period
time point, but continued to increase through the 24- though the change did not reach clinical significance.
week measure despite no additional treatment. Pain se- Regarding medication use, we found that the proportion
verity decreased from 4.92 (95% confidence interval [CI] of subjects taking any type of pain medication over the
¼ 4.58–5.26) at baseline to 2.72 (95% CI ¼ 2.19–3.32; previous two weeks fell from 87% at baseline to 65% at
P < 0.01) at 24 weeks. Pain interference decreased from the 24-week mark (P < 0.01). However, the self-
3.59 (95% CI ¼ 3.17–4.01) at baseline to 1.87 (95% CI reported data on this outcome were too inconsistent to
¼ 1.38–2.37; P < 0.01) at 24 weeks. Fifty-five out of 95 allow for analysis of specific medication categories.
patients (57.8%) showed at least a 30% reduction in There were no serious adverse effects reported in this
pain severity, and 64 out of 94 patients (68.0%) showed study and only infrequent minor adverse effects such as
at least a 30% reduction in pain interference. The aver- needle site irritation and bleeding and tiredness after
age number of acupuncture sessions completed was treatment.
6.7. Changes in pain severity and pain interference are
shown in Figures 1 and 2. Discussion

The number of pain-free days in the past two weeks Pain is a primary symptom that prompts health care
also increased significantly during the course of the seeking including for care by acupuncturists. Low back
study from 1.4 (95% CI ¼ 1.0–1.8); P < 0.01) at baseline and neck pain were the leading causes of disability in
to 4.8 (95% CI ¼ 3.7–5.8; P < 0.01) at 24 weeks. 2015 in most countries [6], and approximately 12% of the
Change in pain-free days is shown in Figure 3. US population age 25 to 74 years has clinically defined
osteoarthritis (OA) of some joint [56]. There is evidence
We also found a statistically and clinically significant de- that acupuncture is effective for chronic pain including
crease in depression from baseline to 24 weeks as headache [57] and migraine [58], temporomandibular

BPI pain severity


Estimate marginal means

Baseline Midpoint End point

Figure 1 Brief Pain Inventory–Short Form pain severity. BPI ¼ Brief Pain Inventory–Short Form.

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Kligler et al.

BPI pain interference


6.00

5.00
Estimate marginal means

4.00

3.00

2.00

1.00

0.00
Baseline Midpoint End point

Figure 2 Brief Pain Inventory–Short Form pain interference. BPI ¼ Brief Pain Inventory–Short Form.

Pain-free days over the past 2 weeks


14.00

12.00
Estimate marginal means

10.00

8.00

6.00

4.00

2.00

0.00
Baseline Midpoint Endpoint

Figure 3 Pain-free days.

disorders [59] shoulder pain [17,18], pain of the lower coverage for acupuncture creates a significant barrier to
back and neck, and osteoarthritis of the knee [15,16,19– access to individual acupuncture for patients from under-
30,60,61]. A 2016 meta-analysis of acupuncture trials for served and low–socioeconomic status populations; offer-
neck, lower back and shoulder pain, knee OA pain, and ing acupuncture therapy in the group setting is a
headache/migraine show that relief persists for 50% to potential solution to this access problem.
90% of patients even at 12 months’ post-treatment [31].
These trials, however, are of acupuncture given in individ- Depression and other mental health comorbidities often
ual sessions. The cost and lack of universal insurance contribute to disability and reduced quality of life in

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Acupuncture Therapy in a Group Setting for Chronic Pain

Depression
20.00
18.00

Estimate marginal means


16.00
14.00
12.00
10.00
8.00
6.00
4.00
2.00
0.00
Baseline Midpoint End point

Figure 4 Center for Epidemiological Studies–Depression Scale results. CES-D ¼ Center for Epidemiological
Studies–Depression Scale.

patients with chronic pain. Although studies are ongoing induced xerostomia [71], and for pain and peripheral
regarding the impact of acupuncture on depression, a neuropathy in HIV patients [37]. However, no large-
2010 systematic review with meta-analysis found acu- scale effectiveness trials of group acupuncture for
puncture’s benefit to be similar to that of antidepressant chronic pain have been published to date.
medications [62]. A 2012 systematic review found that
acupuncture alone was comparable with antidepres- In previous work, we found it feasible and effective to de-
sants or psychotherapy alone in the treatment of de- liver individual acupuncture sessions in an underserved
pression [63], and a 2013 systematic review found a primary care setting [32,33]. In this study, we confirm
high level of evidence to support the use of acupuncture that acupuncture therapy in a group setting is feasible
in treating major depressive disorders in pregnancy [64]. and effective in a primary care clinic in New York City.
A large-scale 2013 trial found that acupuncture and We found a significant reduction of chronic pain and de-
counseling can provide long-term benefits for many pa- pression over eight weeks of treatment. Perhaps more
tients with ongoing depression in primary care [61,65]. importantly, we found that this benefit was sustained
Acupuncture is also shown to improve quality of life in through 24 weeks with no additional intervention despite
patients with depression [66]. the fact that our treatment intervention was only eight
weeks long as opposed to the 12- to 16-week duration
Group acupuncture (also known as “community acu- more common in clinical trials. These findings clarify that
puncture”) sessions and clinics have increased in the acupuncture therapy customarily given in an individual
United States and in other countries to meet the setting can reduce chronic pain and depression in pa-
demand for care by those who cannot afford out-of- tients with chronic pain when given in a group setting as
pocket fees associated with individual session care. well. Group acupuncture may therefore be considered a
By group acupuncture here, we mean treating safe and effective option for chronic pain patients.
patients in turn in a shared setting, primarily seated in Although our patient sample in this study was not exclu-
chairs proximal to one another. Patients may or may sively drawn from a low-income or underserved popula-
not interact with one another, but can hear conversa- tion, there is no reason to assume that the pain
tion between other patients or between other patients outcomes we demonstrated here would not apply to
and the practitioner. Although there are no official these populations, potentially addressing the access is-
statistics on the number of community/group acu- sue that impacts those of a lower socioeconomic status.
puncture clinics, as of 2012 at least 200 such pro-
grams were operating around the country, and this Limitations
number has certainly grown at this point [67]. Group
acupuncture has been studied for feasibility and qual- Our trial used a quasi-experimental design and did not
ity of patient experience [67–70] for knee OA have a control group. While acupuncture has been
[34,35,70], for cancer pain, for peripheral neuropathy shown to be effective for chronic pain and depression in
and digestive symptoms [36], to relieve radiation- controlled trials, because of the lack of control group,

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Kligler et al.

we cannot definitively say that the acupuncture therapy 6 Disease GBD, Injury I, Prevalence C. Global, re-
was the discrete cause of the benefit to subjects here, gional, and national incidence, prevalence, and
as opposed to the nonspecific treatment effects of care years lived with disability for 310 diseases and inju-
or of participating in a group research project. A more ries, 1990–2015: A systematic analysis for the
ideal design would randomize between group and indi- Global Burden of Disease Study 2015. Lancet 2016;
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Centered Outcome Research Institute (PCORI)–funded
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Disparities in Pain Treatment (AADDOPT-2) trial, is tak- The health and productivity cost burden of the “top
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