Sertraline 

is used to treat depression, panic attacks, obsessive

compulsive disorder, post-traumatic stress disorder, social
anxiety disorder (social phobia), and a severe form
of premenstrual syndrome (premenstrual dysphoric
disorder).This medication may improve your mood, sleep,
appetite, and energy level and may help restore your interest in
daily living. It may decrease fear, anxiety, unwanted thoughts,
and the number of panic attacks. It may also reduce the urge to
perform repeated tasks (compulsions such as hand-washing,
counting, and checking) that interfere with daily living.
 Drug-drug. Agents with antiplatelet properties ( NSAIDs,
P2yI2 inhibitors, SSRIs), aspirin, clopidogrel, heparin: May
enhance antiplatelet effect and bleeding risk. Monitor
therapy.
 Amphetamines, buspirone, dextromethorphan,
dihydroergotamine, lithium salts, meperidine, other SSRIs
or SSNRIs (duloxetine, venlafaxine) sumatriptan, TCAs,
tramadol, trazodone, tryptophan: May increase the risk of
serotonin syndrome. Avoid combination of drugs that
increase the availability of serotonin in the CNS; monitor
patient closely if used together.
 Apixaban, dabigatran, edoxaban, rivaroxaban: may
increase bleeding risk. Monitor therapy.
 Cimetidine: May decrease clearance of sertraline. Monitor
patient closely.
 Disulfiram: Oral concentrate contains alcohol, which may
react react with drug. Use together is contraindicated.
 Fosphenytoin, phenytoin- may increase phenytoin
concentration, monitor phenytoin level and reduce
phenytoin dosage if needed.
 Linezolid, methylene blue- may cause serotonin syndrome.
Use extreme caution and monitor patient closely.
 Somnolence- The state of feeling drowsy or ready to fall
asleep.
 Paresthesia- a burning or prickling sensation that is usually
felt in the hands, arms, legs, or feet, but can also occur in
other parts of the body.
 Hypesthesia- unusual or pathological sensitivity of the skin
or of a particular sense to stimulation tactile hyperesthesia
of the leg.
 Hypertonia- is a condition in which there is too much
muscle tone so that arms or legs, for example, are stiff and
difficult to move.
 Dyspepsia- is a pain or an uncomfortable feeling in the
upper middle part of your stomach area.
 Anorexia- An eating disorder that ca reduced appetite or
total aversion to food.
 Myalgia- is a muscle aches and pain, which can involve
ligaments, tendons and fascia, the soft tissues that
connect muscles, bones and organs. Injuries, trauma,
overuse, tension, certain drugs and illnesses can all bring
about myalgia.
 Pruritus- Itchy skin is an uncomfortable, irritating
sensation that makes you want to scratch. Also known as
pruritus (proo-RIE-tus), itchy skin is often caused by dry
skin. It's common in older adults, as skin tends to become
drier with age.
 Diaphoresis- perspiration or sweating
 Pimozide works by changing the actions of chemicals
in the brain. Pimozide is used in people
with Tourette's syndrome. Pimozide suppresses the
physical (motor) and vocal (phonic) symptoms of tics
when these symptoms interfere with daily life
function.

 Monoamine oxidase inhibitors are a class of drugs

that inhibit the activity of one or both monoamine
oxidase enzymes: monoamine oxidase A and
monoamine oxidase B. They are best known as
highly efficacious anti-depressants, as well as
effective therapeutic agents for panic disorder and
social phobia.
can sertraline be used in pregnancy?

Can this drug be used in children?

This drug is not approved for use in pediatric patients for the major depressive disorder but it is
approved for obsessive-compulsive disorder in children older than 6 years.

Can you drink alcohol while taking sertraline?

No dli sya pwede na mu inum ug alcohol while naga take sya ani na drugs, and this is also true for the
other SSRIs. The side effects of Zoloft include drowsiness and dizziness, and drinking alcohol may make
those side effects worse.

Are there any risk for taking sertraline for long period of time?
there are no known problems associated with long term use of sertraline. It is a safe and
effective medication when used as directed.

Can sertraline increase the risk of suicidality among children and adults?
Depression and certain other psychiatric disorders are themselves associated with
increases in the risk of suicide. Patients with major depressive disorder (MDD), both
adult and pediatric, may experience worsening of their depression and/or the
emergence of suicidal ideation and behavior (suicidality) or unusual changes in
behavior, whether or not they are taking antidepressant medications. This risk may
persist until significant remission occurs.

In short-term studies, antidepressants increased the risk of suicidality in children,

adolescents, and young adults when compared to placebo. Short-term studies did not
show an increase in the risk of suicidality with antidepressants compared to placebo in
adults beyond age 24. Adults age 65 and older taking antidepressants have a
decreased risk of suicidality. Patients, their families, and caregivers should be alert to
the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If
these symptoms emerge, they should be reported to the patient’s prescriber or health
care professional. All patients being treated with antidepressants for any indication
should watch for and notify their health care provider for worsening symptoms,
suicidality and unusual changes in behavior, especially during the first few months of
treatment.
SSRIs release two chemicals in the brain that kick in at different times,
causing a period of negative effects on mental health, the authors report.
The first chemical is serotonin, which is released very soon after an SSRI is
taken but might not lessen depressive symptoms until after a couple of
weeks. The second chemical is called glutamate, which can take a few days
longer to be properly released. According to the new study, the serotonin
neurons send off a dual signal to the two chemicals, causing the variant time
frames for the chemicals, and therefore the problem period