PATHOPHYSIOLOGY

ORIGIN:

GBS
Non Modifiable and Modifiable Risk Factors
Sign or Symptoms
Pathophysiology
Aggravation

Modifiable risk-factors

 - Client was infected be suffering from

campylobacter bacteria, influenza virus, Shared ganglioside
cytomegalovirus, Epstein-Barr virus, HIV, antigens between
Mycoplasma pneumonia peripheral nerve and
pathogens coat proteins
 - Client underwent Surgery

 - Diagnoses with hodgkin’s lymphoma

Non-modifiable risk-factors

 Age
An immune response is
 The client is 50 years of age initiated, although the
mechanism is unknown at
 Gender this time

 The client is male

IgG antibodies to
Triggered immune Heightened permeability of
ganglioside antibodies
response blood-nerve barrier
serum

Decreased conduction Antibodies attack Increased protein in CSF

velocity. Blockage of nodes of Ranvier and
conduction Schwann cells reduced CMAP amplitude

Acute inflammatory Acute motor sensory Acute motor axonal

demyelinating axonal neuropathy neuropathy (AMAN)
polyneuropathy (AMSAN)
(AIDP)

Antibodies attack
nodes of Ranvier and
Schwann cells