Precipitating Factors: Predisposing Factors:

V
Arthritis (Joint pain) Type 2 Diabetes
Mellitus

Hypertensive
Hyperglycemia
Cardiovascular Disease

Gouty Arthritis

Hormonally influenced Deposition of Alteration of Glycosylation of

cytokine release Mesangial Matrix glomerular proteins (glomerular)
hemodynamics

Formation of acellular Hyalinosis of both Mesangial cell

End-Stage Renal nodules within afferent and efferent proliferation and
Disease Mesangial Matrix arterioles matrix expansion and
vascular epithelial
damage

Diabetic Nephropathy

Thickening of
Increased Glomerular Glomerular Basement
Nephrotic Syndrome Macroalbuminuria Microalbuminuria
Filtration Rate Membrane