DRUG STUDY

Classification Indication & Side Effects & Special Nursing

Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Platelet/bleeding Verify any

Nonsteroidal Treatment of GI distress disorders, severe medication order
Aspirin antiinflammator mild to moderate (including renal/hepatic and make sure it's
y drug (NSAID). pain, fever. Used abdominal impairment, complete.
Trade/ Brand as platelet distention, dehydration,
Name: CLINICAL: aggregation cramping, erosive gastritis, Check the patient's
Bayer Anti-inflammato inhibitor in the heartburn, mild peptic ulcer medical record for
r y, antipyretic, prevention of nausea); disease, an allergy or
Dosage: analgesic, transient ischemic allergic sensitivity to contraindication to
80mg/tab anti-platelet. attacks (TIAs), reaction tartrazine dyes, the prescribed
cerebral (including elderly (chronic medication.
Route: Oral thromboembolis bronchospasm , use of doses 325
Action: m, MI or pruritus, mg or greater) Follow the 10
Frequency and Irreversibly reinfarction. urticaria). rights of Medication
Timing: inhibits administration.
cyclooxygena se
Daily enzyme, Contraindicati Adverse Educate patients
resulting in a ons: Effect: High about their
decreased Contraindicated doses of aspirin medications.
formation of to pts with may produce
prostaglandi n hypersensitivity GI bleeding Encourage them to
precursors. to NSAIDs. Pts and/or gastric speak up if
Irreversibly with asthma mucosal something seems
inhibits rhinitis, nasal lesions. wrong.
formation of polyps; inherited Lowgrade
thromboxane , or acquired aspirin toxicity Ask another nurse to
resulting in bleeding characterized perform an
inhibiting disorders; use in by tinnitus, independent double
platelet children (younger generalized check and correct
aggregation. than 16 years) for pruritus (may any conflicts before
Therapeutic viral infections be severe), administering the
Effect: Reduces with or without headache, drug.
inflammator y fever. dizziness,
response, flushing, BASELINE
intensity of pain; tachycardia, ASSESSMENT
decreases fever; hyperventilati
inhibits platelet on, diaphoresis, Do not use if
aggregation. thirst. Marked vinegar-like odor is
toxicity noted (indicates
characterized chemical
by breakdown).
hyperthermia,
restlessness,
seizures, Assess history of GI
abnormal bleed, peptic ulcer
breathing disease, OTC use of
patterns, products that may
contain aspirin.

Assess type,
location, duration of
respiratory failure,
coma. pain,
inflammation.

Inspect appearance
of affected joints for
immobility,
deformities, skin
condition
 Classification Indication & Side Effects & Special Nursing
Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Patients with Verify any
Fluorouracil Cytotoxic Palliative Asthenia, Moderate to medication order
Chemotherapy treatment of vomiting, severe hepatic and make sure it's
Trade/ Brand malignant anorexia, impairment, complete.
Name: Fluoroxil Action: tumors, hypertension, diabetes.
Fluorouracil is a particularly of the epistaxis, Check the patient's
Dosage: 1000 pyrimidine breast, colon or stomatitis, medical record for
mg/ m² analogue that rectum; treatment constipation, an allergy or
interferes with of gastric, headache, contraindication to
Route: Oral DNA synthesis primary hepatic, dyspnea. the prescribed
by blocking the pancreatic, medication.
Frequency and conversion of uterine (cervical),
Timing: deoxyuridylic ovarian & Adverse Follow the 10 rights
acid to bladder Effect: of Medication
m²/day thymidylic acid carcinomas, as UTI, administration.
resulting to monotherapy or manifested as
inhibition of cell combination urinary Educate patients
proliferation of therapy. frequency/ur about their
fast-growing gency, medications.
cells and causes Contraindicati proteinuria,
cell death. It also ons: occurs Encourage them to
interferes with Contraindicated frequently. speak up if
RNA synthesis. to pts with Most serious something seems
Hypersensitivity adverse effects wrong.
to fluorouracil. include HF,
Myelosuppressio deep vein Ask another nurse to
n, poor nutritional thrombosis, GI perform an
status, potentially perforation, independent double
serious wound check and correct
infections. dehiscence, any conflicts before
hypertensive administering the
crisis, nephrotic drug.
syndrome,
severe
hemorrhage.
Anemia,
neutropenia,
thrombocyto
penia occurs
occasionally.
Hypersensiti
vity reactions
occur rarely.
May increase
risk of
tracheoesoph
ageal fistula
development.
 Classification Indication & Side Effects & Special Nursing
Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Hepatic Verify any

bevacizumab Increased cirrhosis, hepatic medication order
Targeted Cancer First- orurinary coma, severe and make sure it's
Trade/ Brand secondline frequency/ electrolyte complete.
Name: Avastin Therapy combination volume. depletion,
Action: Binds to chemotherapy Nausea, prediabetes, Check the patient's
Dosage: 300 mg and neutralizes with 5-dyspepsia, diabetes, medical record for
vascular fluorouracil (5- abdominal systemic lupus an allergy or
Route: IV endothelial FU) for treatment cramps, erythematosus. contraindication to
growth factor, of pts with diarrhea or Pts with the prescribed
Frequency and preventing colorectal cancer. constipation, Prostatic medication.
Timing: association with Secondline electrolyte hyperplasia/urin
endothelial treatment ofdisturbances. ar y stricture. Follow the 10 rights
Q2weeks receptors. colorectal cancer of Medication
Therapeutic after progression administration.
Effect: Inhibition of first-line Adverse
of microvascular treatment with Effect:
growth retards bevacizumab. Electrolyte
growth of all disturbance s
tissue, including Contraindicat (including
metastatic tissue. ions: symptomati c),
Contraindicated dehydratio n &
to pts with hypovolemi a
Hypersensitivity especially in
to bevacizumab. the elderly,
increased blood
creatinine &
blood
triglyceride
 Classification Indication & Side Effects & Special Nursing
Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Patients who Verify any
Tramadol Analgesics ImmediateReleas Dizziness, suffer from medication order
(Opioid) e: Management vertigo, nausea, emotional and make sure it's
Trade/ Brand of moderate to constipation, disturbance or complete.
Name: Action: moderately headache, depression,
Binds to severe pain. drowsiness. history of Check the patient's
Tramadin muopioid epilepsy or risk medical record for
receptors in ExtendedRelease: of seizure, head an allergy or
Dosage: 50 mg CNS, inhibiting Aroundthe-clock Adverse injury, increased contraindication to
ascending pain management of Effect: intracranial the prescribed
Route: Oral pathway. Inhibits moderate to Seizures pressure. Renal medication.
reuptake of moderately reported in pts and hepatic
Frequency and norepinephrine, severe pain for receiving impairment. Follow the 10 rights
Timing: PO serotonin, extended period. tramadol within Elderly. of Medication
every 6 hours inhibiting recommended administration.
descending pain dosage range.
pathways. Contraindicatio May have Educate patients
Therapeutic ns: prolonged about their
Effect: Reduces Contraindicated duration of medications.
pain to pts with action,
suicidal patients; cumulative
acute intoxication effect in pts
w/ hypnotics, with
centrally acting hepatic/renal
analgesics, impairment,
opioids, serotonin
psychotropic syndrome
drugs or alcohol; (agitation,
uncontrolled hallucinations,
epilepsy, acute or tachycardia,
severe bronchial hyperreflexia).
asthma, May cause
hypercapnia or suicidal
significant resp ideation and
depression in behavior.
unmonitored
settings or
absence of
resuscitative
equipment. Not
intended for
narcotic
withdrawal
treatment. Severe
renal and hepatic
impairment.
 Classification Indication & Side Effects & Special Nursing
Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Pts with fluid Verify any
Ibuprofen Nonsteroidal Treatment of Nausea, retention, HF, medication order
AntiInflammator fever, vomiting, dehydration, and make sure it's
Trade/ Brand y Drugs inflammatory dyspepsia, coagulation complete.
Name: (NSAIDs) disease, and dizziness, rash. disorders,
Advil rheumatoid concurrent use Check the patient's
disorders, with aspirin, medical record for
Dosage: 200 mg Action: osteoarthritis, Adverse anticoagulants, an allergy or
Ibuprofen, an mild to moderate Effect: steroids; history contraindication to
Route: Oral NSAID, has pain, primary Overdose may of GI disease the prescribed
analgesic, dysmenorrhea. result in (e.g., bleeding, medication.
Frequency and antiinflammatory metabolic ulcers),
Timing: and antipyretic acidosis. Rare smoking, use of Ask another nurse to
properties. It reactions with alcohol, elderly, perform an
PRN for inhibits Contraindicatio long-term use debilitated pts, independent double
breakthrough of cyclooxygenase- ns: include peptic hepatic/renal check and correct
pain 1 and 2 thereby, Contraindicated ulcer, GI impairment, any conflicts before
also inhibiting to patients with bleeding, asthma. administering the
prostaglandin hypersensitivity. gastritis, severe drug.
synthesis. Onset: Concurrent of hepatic reaction
Analgesic: 30-60 previous history (cholestasis,
minutes. of GI bleeding or jaundice),
Antiinflammator ulceration. nephrotoxicity
y: ≤7 days (oral) (dysuria,
hematuria,
proteinuria,
nephrotic
syndrome)
 Classification Indication & Side Effects & Special Nursing
Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Thyroid disease, Verify any
dexamethasone Antiinflammator Insomnia, renal/hepatic medication order
y. Antiemetic. Used primarily as facial edema, impairment, and make sure it's
Trade/ Brand an moderate cardiovascular complete.
Name: Action: antiinflammatory abdominal disease,
Adrecort Decreases or distention, diabetes, Check the patient's
inflammation by immunosuppres indigestion, glaucoma, medical record for
Dosage: 8 mg suppression of sant agent in a increased cataracts, an allergy or
neutrophil variety of appetite, myasthenia contraindication to
Route: Oral migration, diseases. nervousness, gravis, pts at risk the prescribed
Decreases Contraindicat facial flushing, for seizures, medication.
Frequency and production of ions: diaphoresis. osteoporosis.
Timing: 2-3 days inflammatory Contraindicated Ask another nurse to
post chemothe mediators. to patients with perform an
raphy. Reverses Hypersensitivity Adverse independent double
increased to Effect: check and correct
capillary dexamethasone. Long-term any conflicts before
permeability. Systemic fungal therapy: administering the
Suppresses infections. Muscle wasting drug.
normal immune (esp. arms,
response. legs),
Therapeutic osteoporosis,
Effect: Decreases spontaneous
inflammation. fractures,
amenorrhea,
cataracts,
glaucoma,
peptic ulcer
disease,
 Classification Indication & Side Effects & Special Nursing
Drug Name and Mechanism Contraindicatio Adverse Precaution Responsibilities
of Action n Effects

Generic Name: Classification: Indication: Side Effects: Renal Verify any

metoclopramide GI agent, Management of Doses of 2 impairment, HF, medication order
antiemetic. nausea & mg/kg or cirrhosis, and make sure it's
Trade/ Brand vomiting greater, or hypertension, complete.
Name: associated w/ increased depression,
Clomitine Action: various GI length of Parkinson’s Check the patient's
Metoclopramide disorders, in therapy, may disease. medical record for
Dosage: is a substituted GERD & gastric result in a an allergy or
1-2 tab/10 mg benzamide with stasis. greater contraindication to
prokinetic and incidence of the prescribed
Route: Oral antiemetic Contraindicati side effects. medication.
properties. It ons: Drowsiness,
Frequency and stimulates the Contraindicated restlessness,
Timing: PO motility of the to patients with fatigue, Encourage them to
q4-6H PRN for upper hypersensitivity lethargy. speak up if
bouts of nausea gastrointestinal to something seems
& vomiting tract and metoclopramide. Adverse wrong.
accelerates Concurrent use of Effect:
gastric peristalsis medications Extrapyramida
without likely to produce l reactions
stimulating extrapyramidal occur most
gastric, biliary or reactions. frequently in
pancreatic Situations in young adults
secretions, which GI motility (18–30 yrs)
leading to may be receiving large
increased gastric dangerous (e.g., doses (2mg/kg)
emptying and GI hemorrhage, during
intestinal transit GI chemotherapy
time. perforation/obstr and usually are
uction), history of limited to
seizure disorder. akathisia
(involuntary
limb
movement,
facial
grimacing,
motor
restlessness).