What is the conservative treatment in MN?

Conservative therapy for MN consists of low sodium diet (,2.3 grams/day), lowering lipids and
controlling blood pressure (target blood pressure #125/75 mm Hg). Inhibition of the reninangiotensin-
aldosterone system (RAAS) with angiotensin-converting enzyme (ACE) inhibitors or
angiotensin receptor blockers (ARBs) are e ective antihypertensive agents that can reduce
proteinuria
and slow progression of kidney disease in patients with nephropathy with or without diabetes, and
for
these reasons they are the preferred agents to treat hypertension in MN. However, the antiproteinuric
e ect of ACE inhibitors or ARB is modest (,30% decrease) and is more signi cant in patients with
lower levels of proteinuria.