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    4 views9 pages

    2015 01 28 00515

    Uploaded by

    malassezia

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 9
    KPATKA XAPAKTEPHCTHKA HA IPOAYKTA KAeovSaTA 1. MME HA JEKAPCTBEHHA DPOAYKT Auuxiopup Axrapute 200 mg raGneTka 99005 [16 | Aciclovir Actavis 200 mg tablets : 7 aap th ti ti oN O4 = a Auwiopyp Axtasuc 400 mg ra6zeTKH A Bee Aciclovir Actavis 400 mg tablets a } 2, KAMECTBEH H KONMYECTBEH CLCTAB AxtupyoTo newectwo b eaHa TaGneTKa ¢ auunKoBHp (aciclovir) 200 uns 400 mg. 3a Mrbatina cnHcDK Ha HlOMOMIHHTe BenlecTBA BIDK T. 6.1. 3. JEKAPCTBEHA ®OPMA Ta6nerxa, Onucanue Auuiciosup Axrasic 200 mg TaGaerkH — KpBrnit ABOHHO MmEKHATH TaGETKH, AHAMETEp 9 mm ¢ an a0 nowra Gan upsr. Auwuciopnp Axrasne 400 mg raGaerKH — xporaH mockM TaGreTEH ¢ JeMMTeNHa Hepra OT entaTa etpaita, ¢ auamersp 13 mm, ¢ 6a 0 nowrH 6x uss. ‘TaGnerxara or 400 mg Moxe 1a Gbae pasnesiena a Abe pase NORM, 4 KJMHWUHH ABH 4.1. Tepanestwum noxazamus ° Tlesenne wa nepeninn H peuNTHBMpane MmpeKuikH, Mpusianenm or Herpes simplex aupye Tun 1 w Tin 2 (HSV-1 w HSV-2) (c muuovenne na HeoHatanen HSV u TexKH HSV newt npu HMyHoKoNmpoMeTHpain neva); . SauuTa oT peuMME Ha MHeKUAH, MpenMBBHKAHH oT Herpes simplex BHpyc NpH naMHeHTA ‘ove sanasen anyentrer; * —_Tpodanairxa ra xeprec supycunt muhexunn, npesuankann ot Herpes simplex BApyC ApH HwytioxoMmpomeTapanin nauvieHa; + Teena a sapnuena u Herpes zoster, npusunenn or Varicella zoster supye (VZV); + __Hlesenne wa HSV-1 w HSV-2, VZV muexiyan npH naunesTH ¢ TexeK HMyHeK jem puUEET KATO naunetra ¢ Hanpesana HIV wnibexuis wn cea KocTHOMOs+uHA TpatierLaaHrTaus, 42. Hoamponxa u Alesuposxa Bespacrmau weHHe Ha xepn Ke * —— evenne Ha xepnec cunmteke wubexunn ~ no 200 mg 5 msrH nNeaHo NeTupH Yaca (nponyexa ce HoMMiaTa 03a). NpombDkHTestHocTTa Ha JewenHeTo € TORKH McpeKIVAH To CLOTBETHO Morke fla ObNe NPOABDKEHO; 4 HA MputoxeHHe ha: etepeny . Tipa naunenra c Texsk umyHeH accuunr (cen TpaxcrialtraiiMa Ha KOCTeH MOSBK) HTK Tpit TAUMeHTH ¢ Hapyuena a6cop6unA OT teppaTa, eHOKpaTHaTa 03a Morke Ala Goue yB0ena (400 mg), TpHWIOXKeHa NeT NETH AHEBHO B HHTepBas YeTHpH Yaca. IIpH Te3H TAUMeHTH CremBa fa 6pne ObcEneHA SBb3MOKHOCTTA OT MHTPAREHOGHO MPIZIOXKEHHe Ha MpOUyKTa; Tipwroxenmeto wa npoaykra TpaGea sa 3aM10MHe KONKOTO € BLAMOXKHO NO-paHio eHeA HatiAaAOTO Ha wmdexunara, Tip peuvausu e Hall-uoGpe Ja ce sari0He no BpeMe Ha MpONPOMAHH MepHoA Hn TIpH nlosea Ha irspaire s1eaHH. Toracxane (MBKLIIpH XepMIEc CHMNIeXc HIKpeKIIMH IPH NALIMENTH CBC 2ania3eH HM Auestia 2osa 800 mg, pasnenera wa 2-4 nos Tlowaxora aosata monce aa ce THTpHpa 20 400 - 600 mg auviknoBHp AHEBHO. TIpaemer wa npoaykra tpaGsa Aa Gyre npeKsonant repHoAHYHO 3a HETTepBATH OT 6 0 12 mecena c OrneA OTHMTTAHE Ha BLIMOANH MPOMeltH B XoMa Ha 3aGos1nBaLIeTO. aaKcTHKa Ha Xepmiec BMpYCHH HH H HMVHOKOMMpOMETHDAHE Mau Enwoxparna 03a no 200 mg aujakioBup ce npianara 4 kpatHo aliesHo mpes 6-uacop utrreppan. Tip naquerm c rex uMyHeH zedauNtT (cle TpaHCrLIaHTaNMA Ha KOCTeH MosbK) HIM npH TaLMEHTH © Hapyiiena aGcopGuna OT YepBaTa, eNMOKpaTHaTa Joaa MOKe Aa Gbxe yaBoeHa (400 mg), pWokeHa neT NBTH JHeBHO s MHTTepsAt HeTHpM aca. TIpHt TeaM TlaLIMeHTH cnenBa na Gone OBeDueHA BLMOXHOCTTa OT MHTTpABEHOSHO MpHNOxesHe Ha MpOyKTa; Tpombmxsrtenyoctra Ha mpamookene ce onpeaens OT TpombKHTeTHOCTTa Ha rlepHOuA Ha pHCK. Aevene Ha sapunena 4 Herpes zoster, npuwmnexn ot Varicella zoster pupyc (VZV) Tlo 800 mg aunxnosHp, netkpaTHo mHesHO pes 4 WacopM HITTepsATH H NpoAMUAHTeNKOCT Ha aewennero 7 aH. TIpa naunewm c vex uMyHeH nepmuurr (cea TpaHCTinaHTauHKR Ha KOCTeH MoyEK) HAM np MauneHTH ¢ HapyueHa abcopuna oT Yepsata creaa a Ghae OGceNeHa BEIMORHOCTTA OT MuTpaBcHOsHo MpHnoxeHHE Ha MpOAYKTa. Hesenmero rpx6sa na Gene 3anOyNaTO KONKOTO © BEIMOKHO MO-cKOpO cHeA HANANOTO Ha mnbexunurd: neyermeTo Ha xepnec 20cTep NOKasBa 110-DOGPH PeaysITATH, AKO Ce 2Al1ONHE KO:IKOTO € BLGMOAHO NO-CKOPO cen NosATa Ha OBpHRa. TIpH HwyHoKoMnpoMeTMpasn Conus c Baputena, JeveHHeTo TpaBpa na samtoune B nuparsre 24 Haca caien nlosnara Ha OBpHBe. Meya ‘Tewenne wa xepnec ewruiexe Ha Tena nad 2 zoduuna sespacm: no 200 mg aunkAoBUp 5 msTH AKeBHO B HpoRWMKeHE Ha S 25H. lena na sespacm 0-2 codunu: nonopunara ot osara 4a aEapacriin. aM Toamponxara npx neue e 20 mg/kg Tero ner neTH aHeBto. Tpocpanaxraka 1 conanteKe Huber HMyHOKOMnpoMeTHpanH mauexTH Heya nad 2 20dmuna sespacm: 200 mg aumktoenp 4 moti aHeBRO. Alewa na euspacm 0-2 2oduv: nonoRMEaTa OT NOsATA 2a BEEPACTHM, mH Tosuposkata npx eta € 20 mg/kg Tersto werupy meth AHEBHO. Jenene Ha papuuena Tleya nod 2 zoduuna sespacm: no 200 mg 4 sti aKenHo 8 npoxbmKeHMe Ha 5 nHH. Aleya om 2-5 2oduuna eespacm: n0 400 mg 4 STH NHeEHO B MpombDKeHMe Ha 5 IKK Aleya nad 6 zodwuna sespacm: no 800 mg 4 mst aHeBHO B NpombmKeHHe Ha 5 nt, wm Tlosava moxe fa ce ws4weaH Mo-mpeuysHo Ha KHslOrpaM TenecHo Tero - no 20 mg/kg 4 roti aneBHo (He TpaBea na ce HARBHIMARA 2038Ta OT lo 800 mg 4 TSTH AHEBHO). Hama cneumbuuni samt OTHOCKO TOTHCKAHe Ha peLDAMeM pM xepriec cHsILIe) seveneTo Ha xepnec s0cTep HIpeKUKE TIPH HMyHOKOMMPOMeTHpAH seU2. Tosmponxa npn naunewtu a crapuecka pespact Brsmoxnoctra 3a HapyiieHna & OsGpeunara yHKuMs npu TaIM KareropHs Mua TpaGea ga Gone sera Nped BHA H OsMponKaTa a Gene cKopareHa croTRETHO (XK. No-somy J[osMpoRKA mmpH Sn6permo yepextane). Tipa nayveHTH 8 crapyecka BBSpAcT, NPMeMAlLIM BHCOKA NlepopanHH ACA aLMKAOBP TpAGRA a ce Noneprka anekBaTHa xYsparaus. Aosupopxa apa nanmentH ¢ 6x6peso yapexmane Tip npuaaraie Wa amaciosxp Tip nannerrH © Hapyuieda GOpeuna dynKuna ce mpenopw4sa OBHUIeHO BRYMaHHe. ‘TpaGea na ce noauepxka anekaTHata xwmpaTautta. Tipu nevesero Ha nautexTH c HapywenHa Ha OxOpeunara OYHKINA H xeprec cHMTINEKe HEMheKUHA ce nperiopbga TpHeM Ha lepopaHH JOSH, KOHTO HAMA Ala LOBENAT 10 KYMYRAUKA Ha MpONykTa B opraweama M 10 HMBa, 38 KOHTO e YoTaHOBeHO, He C2 GesonacHA MPH HNTpaBeHOoHA HAgysas. TIpa TaUnEHTA ¢ TexKa GLOpeskia HeHOCTATBYHOCT (KpeaTHEHHOB KoTHpEHC < 10 ml/min) ce npenopEdBa nosa nto 200 mg auMknosKp sea MSTH nHeBHO Mpes 12 NacoBH METepEATTA, Tipu nesenme Ha xepnec socrep Hnchexuum ce npenopsysa no 800 mg auwKnoBND ska MTH AHERHO npes 12 yacoBH wirtepsant MIpH TaWHeHTH ¢ TexKa OsOpedHa HesocTaTsuHocT (KpeaTHHHHOR xaumpaie < 10 ml/min) u m0 800 mg aumctosnp Tp M-TH AHEBHO Mpes 8 HACOBM HETEpBATH Mpa TNAWHeHTH c YMepeno HspaseHa 6x6peua HenOCTATYHOCT (KpeATHEMHOR KATAPBHC MEKIY 10-25 ml/min). ‘Hawi a mpunoxcenne TlauvetrH, koMTo wanuTear senpymHeHia B rsaTaHeTo Ha TAGMeTKHTe MOraT 2a TH pasTBOpAT ¢ Muntawym 50 ml Bona, KosTo Tapa a ce pasSupKa npesti nHeHe, 43. Tpormsonoxasanas © —— Copexsyscranreniocr KbM alKTOBMP, BATaLKTOBMP WIM KBM HAKoe OT TlOMOUIHHTe euiecTéa, MsGpocn B TowKa 6.1 4 (Cneuuasnm npeaynpexacaus 4 npennasna mepku mpi ynorpeGa Tpana aa ce nomxepxa aaeksaTHa XMApATaLK MpH MaIWeHTH, nexyBannt c anmosMp IV wm ¢ BuCOKH NepopaTHH 03H. Pucket of GxGpeunio yapexkaate, ce YBeaNasa NPM YnOTPeGe wa pyTH HedpoTOKoHTIHH TeKApCTBEHH cpeacrea. ‘YnorpeSa np waunenrn c Ox6pesHn HapyireHHs H NpH TIANHEHTH B CTapyecka Bbapact: AuMKIOBMP ce GHMMMHApa NocpencTBOM GuGpeunTe, Nopanl KoeTO qosaTa TpxGna na Owe CkOTBETHO KOpHrAparia TIPH MANMERTA ¢ GxOpeinn Hapyuren (mx. TouKA 4.2). TipH naupterTH B cTaptecka BLApaCT TpAGEa Ma Ce HMA NPeHBHN BBSMOKHOCTTa 3a MOHMKCHA GnOpesnara GyHKAAK, opanh KoeTo € HeoOXoAHMO AoBATA NH TASH MPyNa NallKeNTH. na BBse cboTBETHO cBOGpasena. [Tpke alWWeHTH B CTApecks BLSPACT H Tesi ¢ ELOPETHM HApYUleNHA € HAIHLE MOBKINEH PHCK OT PABHTHE a HeBponOrHAHH HexenaRH peau, MopaqH KoeTO Tes nanKeHTH TpAGBa CTpOrO xa OxaaT HaGmionapann 32 noawa Ha TaKHBa eexra. [px zoKTamBaHHTe cayaH, TeSK PeaKME ca Hali-o6m0 ‘oSparHMu mpH npeycrakonapale Ha AeueHHero (Bxk. TOUKa 4.8), TIpombimxnrenaH W1 NOBTOPHA KypCOBe ¢ AIHKIOBIP pH cepHOaHO HMyHOKOMMPOMeTHpAHA nayweHTH Moke a AoRee 20 pasBHTMe Ha BUPYCHM laMOpe c HAMalleHa HYBCTRHTENHOCT, KOHTO a He OTrosapaT Ha MpOMEADKABAMLO eYEHH ¢ AMKKTOBMP (BX. TONKA 5.1). 45, Bsaumoneiicrsne c apyrn ekaperneau mpoayktH m pyra opma Ha He ca yeranioseni kaminiano aHasnnwn nexaperaena naaHMonelicTBNA Auweaonnp ce enumuaupa OcHOBHO B HeMIpOMeHeH Bix pes YpHHara nlocpencTBOM akTHBHa peHana ‘Ty6ynHa cexpeuns. Bowiku AeKapersa, KOHTO ce NIpHitarar ellHORDEMeHHO H MOraT Ja Ce KOHKypHpaT lo Toa MexaHHgbM Ha @MMMHMpaHe Mora fa TOBeqaT 0 TOBMINABAHE Ha ninasMeHHTe Konuerrpauni wa auwkioeup. MpoSeneuan a UAMeTHAMH NOBHulaBaT cTORMOCTTa Ha MuioUtTa NOR Kpusata iuiasmena KonuerTpawna/epeme (AUC) 2a allMkx0BHp no TORK MeXaNieshM 4 HaMansaBaT Herosva Gu6pesen KIMpEHC. HlogoGHo nosmuranane croiiocmme ua AUC 2a aunkrosup HeaxTuniMx MeraGoamr Ha Moxopenionat Moder (muyHocynpecaHT, HoTOT3BaH pH TpaHirmaifrApaeM naunerrA) € 6HTO YeTaWoReNO NpH eZHOBPeMeHHO MPHAOEHHE Ha ABATa MpoaykTa. BumpekHi TOBA, He € HeOBKOAHMO Koparupate Aosava Ha auMKiOBMp, opal HerOBHs LUMPOK TeparlesTHUeH! HiLIekK. Excnepnmerramto #scx1en8aHe Mpy NeTuMa NalHeHTH OT MBIKKH O11 NOKA3BA, He MPA eZHOBpeMeHHO ReveHHe Ha Teo c auwEToBMp, AUC Ha O6UIMR npunokeH TeobwiMH ce yaenmuaBa C npHOuenreano 50%. Tipa comstcrsama Tepanwa c auMWIOBMp Ce MIPEMIOpEYBA fla Ce H3MepRAT TasMeHHTe KoMLIeHTpaMli Ha TeodpHONHH. 4.6. Deprummrer, Gpemennocr # kypmene Bpemenniocr Auwetoxup TpaGra za ce npwaara rio Bpeme Ha SpemeaMocT camo KoraTo ToTeHHaRHaTa moma pesuuasa BEIMOKHHTE PHCKORE. B noct-MapkeTHbronus perucrsp Ha cayuaitre Ha Spemenbocr Ha atnin OT npocnesaBave Ha Gpemennm xxeHu, TpeTHpaHH c pasiMasn DopME alumKioBMp. PerMcrpHpaHNTe aH He NOKAGBAT osnuranave 5 Gpos Ha BPONeHHTe nebekTH NpH AeUa Ha MaHKH, NeKYBANH ¢ AUUAKIOBHP, B cpabvesne c oSuara nonyaauns, Kato BponeHtiTe HedeKTA He NOKASBAT OCOGEHOCT HIM ocneyosateneH moje, 38 a Ce npeamonos OFua NpHsHa, Copel AHHH OT MEXkIYHApONHO Inpwetire craHnapTHM TecTOBe, NpH CHCTEMHO MpHTAraHe Ha ALMKNOBUP, He Ce YCTAHOBABAT ewGpuoroxchuH Win TepaToreHEN edeKTH MPH NPOYBAHHS, nponesieHA BEDXY 2all, RUNEXOBE HAM i B npovéeno nectaniaprio HsIINTHaHe KEPXY ILIBXORE Ce YCraHORARAT dheraNi AHOMaNTHH, CAMO exe HORKOKHO MpWlarane Ha MHOTO BHCOKH, TOKCHYNN 34 Malixara 03H. 3HAYeHMETO Ha TSK OTKpHTMA 3a KAHHHUHATA MpaKTHKa He ¢ HoscHeHO. Kepmene Cnea nepopanto npanoxexve Ha 200 mg auliKiOBHp eTKpaTHo aliepHO € ycTaHoBeHa KonUeHTpalLHa B KEpMata, KORTO HagEHMaRa OT 0,6 0 4,1 mbTH TaoH @ rinazwara. Tlo TOOK HAN, NPM KBPMEHe ETETO MOKE JIa IpMeMe C MISKOTO AUMKMOBMP B OH 0 0,3 mpkg B AeHOHOMLWe. Tlopax Toba npouykret 1psGea 1a ce mpivrara c HlOBMLNEHO BHMAKHe MIpH KBPMAYKH 4.7. Esexra supxy cnocoGnocrra sa mopapane m paSota ¢ manana Koraro ce npeuetasa cnocoBxoctra 3a wopupake HM paGora c matin, TpAGEa na ce MMaT NPeHEHA KTMHHYHOTO ChCTORHHE HA NALAEHTa H BLIMOMHHTE HeXeTaHH ekapCTBEHH PeaKIHH. He ca nposeaxaann npoyssanns 3a wacmenmpake Ha eekTa Ha AUKTOBKP BPXy cnloco6HOcrTa 2a uogpapane 1 pa6ora c Mammal. B nomprnenne HeKeaaHHsT eGeKT BEPXY TSH [eMIHOCTH HE MOKE 2a Gxze npeasuten or bapmaxonorMsMiTe NaHAM 34 eKAPCTEEHOTO REULECTEO, 4.8. Hemesann aexapersens peaxmunt Uecrorara a HexenaHuTe peaKUMH Mlo-Zony € NpHOAHDHTeAHO HoMNCneHa. 3a noBeN peaKuHM sHneBa HeoBxomHMaTa HHbopMAllAs, 2a fla Ce HONHCAH HecToTaTa Ha Hexkera) B xomennenve wexenauirre stexapeTaenn peakiuM Morar Ja BapHpat 110 3aBMCHMOCT OT TlOKAsAHMETO. oSmanare Hao; Hexen (CroGutaparieTo Ha TlOnOSHpaHH HexeTaHn peartiins cnem paspemanane 3a yrloTpeGa Ha slekapcTBEHAA npoayer € Ba&KHO, ToBa NOsBONABA 2a NpomBMKH HABMOTeHHETO Ha CbOTHOMeHHETO TlON3A/pHCK 3a nexaperaenns mpoayxt. OT MegHIMNEKHTe CeUMaTHeTH ce WBNCKBA na choGulasaT BCAKA Monosupania HexesiaHa peakutta pes: Mornanurrenna arenunss no nexapersara yn. ,Jlawan Tpyes” No & 1303 Cospna Ten.: 02 8903417 yeScaitr: www.bdabg 49. Tpexosnpane Clnnertoxen mposps: ‘AuwkioBHp ce pesopGHpa YacTHNHO B racTpo-niTectHHaiia TpaKT. TpH npeaosupatie c ‘eaHOKpATeH MpHeM Ha 203% 0 20 g aNKAOBHP He ca YcTaHOBEHH TOKCHNKM edpexT. CayHallNo, NOBTapsUlo ce NpeosMpavle B MPOBIOKEHUE Ha HAKOAKO ANH BOM 20 MpoaBH Ha HExCIAKH edbeKTH ‘or cTpawa Ha KpaHOcMMAaTesTHaTa CHCTENA (raeHe H KlOBPbUaHe) W OT CTpaKa Ha HeppHaTa cHCTEME (craso6onne H o6spxatiocr). TIpw npeaospare cnen napeTeparto NpHoxeHHe Ha NpOAYKTa MOK Aa HaCTeIIM MOBHINARAME Ha CepYMHKa KPESTHHH H YpeaTa ¢ MOCHeRBAMIO pasBHTHe Ha OLOpeuHA HEAOCTATLYHOCT H TpOSBH OT epava Ha HepsHara cHcTeMa (OOMpKAHOCT, XAMIOUMHALW, BESGYAa, NAMATH H KOM). Tevenne: HeoGxoaHMo € HaGmionerMe Wa TalIMeHTHTe 2a NPOABH Ha ToKCH¥HOCT. XeMomanHsaTa 3HAUHTENHO ONPHHACA 38 OTCTPAHARAHE HA AIWMKIOBK OT KPBETa H 2aToRA TpsOBA na ce OOCRAM KATO ‘TepariesTHeH MeTOM MIpM CHNIFTOMATHSHO MpeoaHpake. 5. ®APMAKOJOTHYHE JABBH 5.1. Dapmaxogumamaaun cpoiterna ‘Dapmaxorepanestayna rpyna: AuTHMipeKUMOSHH cpemcTBA 3a CHCTEMHO MpWIOKEHHe, ARTHBYPCHH npoaykTH 3a cHcTeMHO pHoxeHHe, ATC Kon: JOSA B 01 AUHKAOBHP © CHHTETHYCH MYPRHOB HYKAcosMNeH ARBIOF ¢ MPOTHBOBHPYCHA AKTHBHOGT B yenoBNA in vitro u in vivo Bepxy Yosemite Bupycn ua Herpes simplex (noaranose HSV-1 4 HSV-2), Varicella zoster papye (VZV), supyeer na Epstein-Barr (EBV) a unromeratoeupyea (CMV). HEM, icraHe VinuGmropsara axtustiocr Ha auyiciosup crpamo HSV-1, HSV-1, VZV 4 EBV ¢ sycoKo conexrnsia, Exsuvrst tammamnar-xinasa (TK) np sapasl, HeMHGexTHpaHit KIETKH He H3MOT358 edexrusxo auuenoBup Kato cyGcrpar. B pesyintar Ha ToRA TOKCHMHOCTTa Ha MCNKAMEHTa KM Sapasit xneraH wa Gosaitumun © HucKa, Exsuncst TK, axrveupan or HSV, VZV x EBV, npeapsuia AUMKAOEMP B HYKLCOGHANHA aHaTOT aUMKNOBH-MoHOMocaT, KOHTO MO-KaTaTEK Ce MpeRpHLA oT wlerosnTe eHoMMM 8 AKdbocbar H MaKpax B TpHGoCHar. AUMKOBKP TpHDocibar KaHMOLeiICTBA © pupycuara HK nonamepasa, Kato apes BksOMBAaHE BBB sepHrata BoaH 20 HelinoTO Mpexsceante. [To ‘TOM HANH MiEXHOUpa permaKanwara Ha supyonara HK. Kaunusna eduxactioor u Sezonactioct TIpompskwrenoto WM MOBTOPHO MPHIOKeHHe Ha ayHKIOBUP MPH NauHeHTH Cc AeQMIUET MOKE Aa AOBEAE AO CeNeKTHpaHe Ha BMPYCHH WaMOBe C HaMaNIeHa HyECT Morar Ja He OTTOBOpsT Ha NpombuKaBaulIO NeveHHe c allMKiOBUp. IIpA NoBeueTo, TNH KAMHHTHHM CTy'aM BAYCH c HaManlena tyscTAHTeNNOCT ce YCTAHOBABA OTHOC Ha comppxannero Ha pupycka TK. CeoSmaza ce 32 uaMone c mposenera Bupy Gee 6 Caeanara Tepmakonoras € seanpHeTa pH KiacduMpaieTo Ha HexenaHMTe eexTH NO OTHOUIEHNE ‘Ha TAXHaTa YecTOTa: MHOro YecTH (21/10), ¥ecTH (21/100 no <1/10), Hevectu (>1/1 000 go <1/100), peaks (21/10 000 10

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