KPATKA XAPAKTEPHCTHKA HA DPOAYKTA CTBATA 1. HME HA JIEKAPCTBEHDA MPOAYKT [WambIAMTENHA ATEHUMA 10 5 a 7 (Rpanvea raparmepucmune 8 AUECAI MPOTEKT 100 mg cromauo-yerotiumen ta6inerii ACESSAL PROTECT 100 mg gastro-resistant tablets 2, KAYECTBEH H KOJIMYECTBEH ChCTAB Boaka cromamo-yeroliunsa Ta6nerka ctaepaa 100 mg aleristeaatuatona xucenua (acetylsalicylic acid), 3a mona cHHcbK Ha NOMOUIHHTe BeulecTBa, BHoKTe TOUKA 6.1. 3. JIEKAPCTBEHA DOPMA ‘Cromauo-yerottunea taGnetKa, Beam, xpbrau, aeolivowsmexHann dumMupani ctomaumo-yeroiimen Ta6eTKH. 4 KJEWAM JAH 41 Tepanestaune noxasannn ALIECAJITIPOTEKT noxasatt npn exspacran sa: + nevetme Ha HecTaGunnia cTenoKapaHa 1 OcTEp MHOKapseH MMipapkT, KaTO acT oT craHnapmaTa Teparins; + npodwiarrina na nosropen muokapaen unchape, tpoMGoemGonusuM Cnes XHPYprHMEN H AYA varrepseHi Ka aptepuasin xpuBoHoctt cEao8e, karo ACVB, PTCA, npexomitn wexeMnutin aTAKH 1 MOsbYeH mxbapKT cilen TlogRa Ha NpOApOMATEH CHMMTTOMH; + sa uamasiaBaHe Ha pucKa OF mspsuNteH MHOKApNeH HHapKT MPH JULIA CLe CEPHEHO-CEsIOB PHCK, karo saxapen AaGer, xHMepAMTgeMHs, apTepHasia XHTPTOHHS, SATTECTABAHE, NOTIOHOTYIEHE, anpesnaaa Bespacr. 42° Nosuposxa u naywa na mpunomenne Tcouponxa Hecmaburma cmenoxapous Apesnara 2008, © KoxTO ce nocTHra anexsarHo HHXHOMpaHE Ha TPOMGOUNTHATA arperaus € MEKIY 100-160 mg. Tipenoppurrena goza - 100 mg nenEixk aNeBHO. Ocmrop unibapem na suoxapoa ‘Alesuara nova, ¢ Konto ce NocTura aueKsaTHo HEXxuOApane Ha TPOMGOUWrHATa at 75-300 mg. Tipenopsunremia nosa - 100 mg semua aHeBHO.Tporpunaxmuxa na nosmopen muoxapden wnpapam Tipenopswsana nHesna noza ~ 300 mg sei aHeBHO, Apotpuraxmusa caed xupypewau u dpyeu uneazuenu unmepoenyuu na apmepuannume cedose Aveonara nosa sapupa B xManasona 100-300 mg. Tipenopessana nosa - 100 mg went 2He8H0. Tpodpuxaxmuna wa npexodnu uccesouu amaxu u smoxeuen unpapsm Aseonara 20va wapupa » Auanasova 30-300 mg, Tipentopsszana nosa - 100 mg nentnoc puteat0. Mpopunaxmmuna na mepeusen suuoxapoen widpapem Tipenoprupana 2038 — 100 mg BeaHba AHeBHO HH 300 ‘Ing pes eH. Hawn na npynoxenue TaGaeniarre ce mpuemar mpenl xpantene ¢ ronsMo KORMYeCTHO TeUHOCT. 43° Dporasonoxasanns * — Cappxsyacrairrentoct KBM akTHBHOTO BeLIeCTEO HIM KLM HaKOe OT TloMOULLHTe BEULeCTBS, sb poew B Tonka 6.1; + Capexuyersurennocr k6M apyru cammmutara; * — Avtaunesa 32 6porncania acta, npesHssHKaHa OT MpHeM Ha CAAMUUMNATH WIM BeMIeCTBA c MOAOSHO JelicTaue, ocobeno HCTIBC n siexapetsa oF rpynata ananreTHuy-arrTummaperHus; * — Axrisia cromauma H myogenanna s38a W/inm akaMeiesa 3a CKOpoUlMa racTpo-MiTeCTHHATHA xemoparus; + Xemoparmua avatesa, xeMopnnus, rpomGoumronesis; + Exnionpemenno npiuioxerme ¢ Merorpexcar, npuiaran B x0sa > 15 mg/cemuro (sioKre ToHKA 4.5); + Tieppit nocnezes tpumecrsp Ha Gpementiocrra (Broke TouKa 4.6). 44° Crennanm npenynpexieums w mpeanasin mepia npm ynorpeba Toss nexapersen nponyxt rps6sa xa Gwe mpunaran c ocoSeHo BHHMAHHe H TONKA OUetKA Ha csoTHOUIeHHeTo Toma/pacK npH: + Jlaua, npHemauyt arraxoarynarn; > Tlanenti ¢ ananesa 2a cromaunor 1 spesxH 5981, BRI. XpOHHA HIM peLUARMBMpala s38eHa Gonecr, wie racTpo-mrecTHBIaM KPBEOHSIBI; - Bot c wapyuienus ia Gx6pesniera nit veprionpoSHara dyHKus; rt Tlauwenra ¢ wssecTaa ceppxsyscreurentoct eM HCTIBC WaH Apyra arorun, AteTicanunnosara Kicennita Moxe 1a MPOBOKHpA GpoHXOCTasEM, RETMATHYEH MpHCTEA AME [a NPcAWSBHKa Npyrts PeaKUMH Ha CBPEXYYECTBHTEMHOCT. PHCKT € NO-BHCOK MpH NauveHTH c 6pouxHATKA Actua, centia xpewa, HasanHa NOAHNO3a WAIK HAKOH XpOHHCHR GenORpOGHH 3AGonABAMKs, KAKTO H TIpH ‘AMA © NIpYPHTYC, YPrvikapHs HIM APyrH KoxkHM 3AGONABAHMA, CBEPSAHM CbC CBPBXYYBCTBNTEHOCT KEM pasmuvern aneprev, AueniicaMiniosaTa KAcemHa, nopat” HHXHOHTOPHNS CH exheKT BUPXY arperauptara Ha TPOMOOUITITe, Moke a OBeE 10 NOBMILeHA CKORHOCT KEM KEPBEHE H 0 KPLBOMRIEBH NO EpEME H Ca ‘ETepBCHLIMH, BK. MATKH XHPYPrHHHH OffepaUINH KATO 3u6Ha eKCTPAKU. 7TIpn naunewrn c noxarpa WM TaKHBa, pH KOKO eTHMHHEpANCTO Ha THEKONHATA KHCETUH € HAPyINEHO, ‘AOMeNHETO c aueTHDICAIIMIYATOBA KHCEAHHA NOME JA NPOROKHA NORArpOseH MpHETEM. Teawatprma nonyzauna Tlopani onachocr or pasirue Ha cHiiapoMa wa Reye, Tosi UpoaykT, KAKTO H APYTH NeKapeTea, (SbSPrRALIM aueTIMICcAMMUTIOBA KUCERHHa, He TpAGRA NA Ce MpHeMaT OT ella H OOH, OcoGeHO Mp saonspatns, nporHdamH ¢ BHCOKA TeMneparypa, OCBCH B CAYYAHT, MPH KOHTO ¢ 6H HasHANeH OT NeKAp H Apynare TepantesTHsi4M MepkH ca ce oxazani HeycroMTt. 4.5 Bsaumonelicrenc ¢ apyru ekapcrseuu mpoayKTH W ApyrH PopMu Ha BsaRMonelicTBRE Aulerivicanaunnonara KHcemMma Moxe 2a wsaHMonelcTRa C pyri enHoBpeMeHHo NpHnaraHn nexaperEa, Topasit KOETO NNpH JeyeHHe ¢ TOSH MPORYKT € HeOBXOAHMO a ce MMA NPEMBHN cHemHaTa macbopMaLys: TpormsonoKasarm KomOusiannu Memompexcam, npunacan ¢ 0030 215 mg cedmusmo - npoTHBonLsmasitrenuuTe xexKapeTsa NOnIKABaT Gx6peunia xiupee Ha MeToTpexcar, a ASA ro HaMeCTBA OT MeCTaTa Ha CBDpIBAHe ¢ THnaIMeHHITe RPOTeHHH, KoeTO BOAM NO NORHUIABAHe Ha HerOBHTe MAgIMeHU KONLICETpAMvAH H PASBETHE a XeMOTOKCHSHOCT (piDKTe TOUKa 4.3). HH KO) 1 oor me Memompexcam, npunaean 6 0020 < 15 mg cedvamno - mpoTuaosLsnantTenHue eKapcTea NOHoKABaT GuGpeurus kaupsuc Ha MeToTpexcar, a ASA TO H3MeCTBa OT MeCTaTa Ha CBbp3BaHe C NNaIMeHHTe NPOTCHHH, B pesy:nTar Ha KOETO Ce TOBHIIABAT TuIaaMenHTe My KOHUCHTpALLHN, a PUCKST OT XeMOTOKCHMHOCT HapacrBa; Kymapunosu anmucoazynanmu xenapun - Homiien puck OT KpbBOWATNBH B PesynTaT Ha ANTUBEH ‘rexnOurropen ecbext expxy TPOMGOLOETHaTa arperaus H MOMecTBAHe Ha NepopanHuTe aNTHKOaryaaHTM OT Mecrara Ha caxpanaHie ¢ nlasMeHTTe mpoTeMHh; Ypuxoxypwioin cpedemsa (Gens0pomapon), npoGeneyud ~ NOHKOKeH YpuKo3ypHueH exper B pesymrar Ha XouKypeHTHn ssamonelicTEHA ¢ MHKOMHATA KHCeTHHA Ha HBO GuGpewa TyGy:Ha eKCKpeUHA; Aieoxctn — nosnurapane Ha ruieamennre My WHA BCheNCTEHe HaManaBane Ha 6sOpeqiaTa eKcKPEINA; Opamu axmuduabemi npodyxmu i uncynun - yeussane Ha xAMOTAMKEMIHLA HM eoheKT B pesymTaT Ha auanoruen edext oT crpana Ha ASA u usmectsane Ha cymdanmypeltiie cpencTBa oT MecTara Ha ‘coupasarie ¢ mulasMenTe nporeHH; Tpombomumuyu u Opycu aumumponBoyumnu cpedcmea - Mobuuien prick or xeMoparnit; (Cucmennu zaoxoxopmuxoudu (c wakmovenne Ha cay‘aHTe, B KONTO ce mpHnarar 38 cyGCTHTYHpALLo eveHive) - NosmmaBare KIMPLHCA Ha XpOHHMHO NpHAaraltara BEB BHCOKH 03K ASA. Tosa NOX Aa AOPEXE AO NOHIPKCHNE Ha CepYMHHTe HUBA Ha CAMMLIATATA WM Aa NOBMIM pHCka OT CaMALANOBA ‘TOKCHMHOCT TIpH npeKpaTaBaHe MpHeMa Ha KOPTHKOCTEpOHIA. ASA rpa6sa za ce mpiara ¢ ocobeHo sHAMaHMe npH exHHOBpeMeHHa ynoTpe6a ¢ rMOKOKOpTHKOCTEpOHAH ‘pH nauvesmire, erpaauust oF xeMOnpoTpoMGHHeMHs TIpu eatiospemenen mpHem Ha cHcTesn rmoKoKopTHKoHsH H ASA ce noBHidaBa pHckbT OT CTOMAlLIHO- ‘speni yauepaunn n xewoparin; Bampoeea kucemuna~ nosmiuera ToKcHHOCT Ha NOcHeAHATa, Not cBppapane c nnasmennte mpoTeHuit;,Héynpoden — anurupen edext no orHouenve Ha HEXHOMpAHeTO Ha TPOMOoUMTHATA arperalus; Aaxoxon — noBuureH PUCK OT ypexAAHE HA CTOMAIIHATA THTABHLA H YAWUKABAHE BPEMETO Ha KEpECHE B Pesysrrat Ha anwrunes edexr. 46 @eprumerer, Gpemennoct u xupmeue Bpememiocr Pesysrarare of nponeseHn enunemnonorH4nn TMIPOY4BAHHA JABAT OCHOBAHHE MPHIOXKeHHCTO Ha CAMMUWWIATH B TEPBHA TPHMECTSP Ha GpeMeHHocTTa fa 6k/le CESPIBAHO ¢ NOBHUIEK PHCK OT pasBHTHe Ha MaxbopMaiuin & ILIONG, KATO HerTiao saTBapsne Ha TeEpAOTO HeGue, CEpAeHA MeDeKTH H Ap., MaKAD He npoy¥satie obxeamamo 32 000 aBoHKH maliKa-HonoponleHo He € YoTAHOBeH NOBHUIeH PHCK OT Manopaaln calen MpHen Ha NpoRyKTa B MpenlopssiBaxHTe AHEBHH no3H, Bompeku Tosa, canHUMTATHTe ‘TpAGba Ja Goer npwaran B Mepuona Ha GpemeHHOCrTa caMO Cnen CTpOTa OUCHKA a CLOTHOMeHHETO NOTEHUMAIHA Noma 38 MaiikaTa-BLSMOIKCH PHCK 3a Toa. Tipatoxenmeto 1M BsD BHCOKH 03H NPes NOGEAKAA TpHMECTAP MORE Aa ROBENC 10 YAWDKABAHE Ha Speennoctra, Homo sarsapane na ductus Botali w rloruckavle Ha KONrpaKTWUMTeTa Ha MaTKATa. Hanmue e noevuteva KIOMHOCT KbM KPLBOHSTNBK, KAKTO OT Crpavia Ha MalikaTa, TaKa W OT crpaka Ha nopoponeHoro. TiproxcriieTo Ha BHcoKH 034 ASA (>300 mg aHeBHo) HenocpeneTseHio npenM paxmaKeTo cB3jaBa PHCK or HETTpakpalMATHA KPLBOHSTHBH, OCoGeHO MpH HexOKOCeHN. Kepmene Cammuurarie ce exckperupar & amu konusectea 8 MaiiiaHoTo M”aKO. Jo MOMeHTa He ca ycraHOBeHH HeOKeNaHH PeaKUHH MPH HOBOPONeHH cated cnyvaiiva WK EAHOKpATHA ynoTpe6a OT crpaHia Ha Maiikara, TIpH penoavo npunoxeHie HH MpHen Ha BACOKH 03H € HeOOXOMHMO MpeycCTaHOBABAHe Ha KEpMeHeTo, 4.7 Egewrn pypxy cnocoSuocrra 3a modupane a pa6ora ¢ MamnaH. Auecan [Ipotexr ne nloannxsa crocoSiocrra 2a uiotpypaste H paGora c MAINA. 48 Hexenana zexapersenn peaxunn Hexxenanmte nexapcroenu peaxuumn ca rpymmparm a Gazara wa cHcTeMa- oprax- xnac. B paMKure Ha BaKa OpraHona cicTema WecToTaTa hia HexeNaHHTe PeaKIIHH Ce ONpeNEA KATO: MHOCO HECTH 21/10), seer (21/100 0 <1/10), nevecTH (21/1 000 20 <1/100), peaKs (21/10 000 0 <1/1 000), Muoro peak (<1/10 000) x ¢ HensnecTHa uecroTa (He moxke a ce ONpeseaM OT HANMUULTe naHHH) ‘Hapyurenua na xpsera n_| Yecmu: smncbuara cucrema Sacwiena exnoHHocT KEM KupBeHte, Pedxu: TpomBounTonenns, rpanysowrroza, annacrisria axenna C neussecmna vecmoma: Caysan na xeppene ¢ yanmkeHo BPoMe Ha KEpBEHE , KATO eHCTaKCHC, Turueanno Kepsene. CHMMTTOMHTe MoTaT na nepcHCTUpar nepHon or 4-8 sHM cxea Mpexpatasane MpHeMa Ha i kuceanna. B pesysrrar moxe fla ce RaGmonasa 10: KBpBeHe TIpH XMpyprHuHM MpoueaypH‘Comectsyeamto (xematemesa, Meneria) WIM OKYATHO FACTPOMHTECTHHAMHO KEPBEHE, KOTO MOXKE sa LOBETE AO *EIEIO- AegmunTTHa aneMus (110-vecTO MpH NO-BHCOKH J103H). ‘Hapyurening wa umynuara | Pedxu: eucrema Peaxum Ha capexyyscreHTesHOCT, aHTHOeHeM, AleprHsieH OTOK, atagpwTaKTHIHH PeaKiNNH BKITOUHTENHO IHOK. MeraGonuspo H C neussecmna yecmoma: Hapyuents Ha Xumepypnxenua xpaoemanaremtiara ccucrema ‘Hapymenna wa neppara | PeOxu: cnetewa Barpevepenent xppnowsaa Cnewssecmua veemoma: Traso6oae, cneroseprex Hapyuienna na yxoro u | C newsaecmna vecmoma: sa6upuerra Hamanen emyx; Tuatye Ceaopn napyuienaen Pedku: Xenoparuent packynir Pecnuparopu, “Hevecrm Topakannu Pwr, aveniien MequacTHHamHH Hapymienna Peowu: Bpoxocnasbm, npvcreny wa acta Hapymenis wa Pedxu: penporyxrasnara Menoparns cHcrema ¥ MuiewHara esa Hapymenia na ecmu: ‘cromamnoupesiis rpaxr | Jacnencus Pedwu: Teaxpx HHTECTHHAIICH KPBBOHSIUB, TAeHe, NOBPbIIAHE racrpos pes C neussecmua wecmoma: Joba Ha cTomaxa WIM ABaHaneceTONpLCTHHKa H Nephopauws ‘XenaroGumnapan C newssecmna veemoma: | napyenna “eptionpo6ua negocrarunocT Hapywienna wa xoxara n | Hevecu: nOAKORHATA TEKAH Ypruxapia Pedu: Cuunpom a Steven-Johnsons, ciiapom na Lyell, nypnypa, epirrema WoRosyM, epHTema mysmruhopme Flapyurenna Ha CC weuseecmua wecmoma: GeOpennre HmuxowmTe | Hapymena 6s6peqna dynxuns moran CyoSuanane Ha Nojosmpany HexenaHi peaxmn CroSuananero na nogoaupari Hexenaiti peaKNH cnex paspemasane 3a ynorpeta Ha Mponykr e naxkio, Tosa noasosiaBa 2a npORMDKH HASTONeHNETO Ha CKOTHOUIEHMETO, JekapeTaeHx nponyKT. Or MeAMUMNCKHTe CNeLUMAMHCTH Ce HHCKBA na CLOBUIABAT HeoxesiaHa peaxuns upes:Hismrumurresma arenuis no nexapersara A. lana Fpyen Ne 8 1303 Coopus Tea.: +359 2 890 3417 yebcaltr: www.bda.bg 49° Tpexosmpane TIpeaosupaniero (repanestiiHo ¥1H MHLDUIeHTHO) ¢ AUeTILICANNANORA KUCETHHA MOE Jit AOBEE HO MHTOKCMKALIAS, KONTO NpH THA B CTAPHECKA BKEPACT H MAIKH NEUA MOIKE Ha GBH CEpHOaHA, & B HAKOM ‘cHysaM Moxe sa Gale c saraneH uBKoA. Kaveri cuunroms ‘Yepeno Texcka MHTOKCHKALWNA — LIM B YUIMTe, HApYUIeHAA Ha CnyXa, 'NABOGOMHE, CBETOBPTOX, o6spxaniocr. Kopexumara Ha mpHeManara no3a BogH No HaManawanie Ha cHnaTa HM ‘HLTH AO TAXHOTO orsnyuanatie. ‘Teaxka weroxenkauns ~Tpecka, xnrtepseHTualins, KeToali038, pecmmpaTopia ankancaa, MeTaGontTHa AUHO3A, KOMA, CEPHCYHO-CEAOB KONANC, THXATeTHa HEAOCTATYHOCT, TEKKA XHTOTHKEMH. Tleweune HesaGasira xocnirransauix, cTomauia npoMHBKa H MpHEM Ha AKTHBEH BEIveH, MOHMTOPHpaHte Ha ‘NokasaTenMTe Ha aNkaHO-KHCENHHHOTO PaBHOBECHE, aTKAMMaHpaHe Ha ypHHaTa (nloxABpxane Ha pH na Yphtiara 8 nmanasoHa 7,5-8), bopeupania ankamaaupana mHypeaa MpH THaSMeHH CANMLYAIOBH onyenrpauman ag, 500 mg/l (3,6 mmol/) npu ssapactaa u 300 mg/l (2,2 mmol/l) mpu xeua, XeMOMMamIN3a, BLaCTaHOBABANE Ha BOMHA Gasanc, NOAKOAAUIO CHMMTOMATHHHO sIeHeHHE. 5. ®APMAKOJIOrH4HH CBOHCTBA 5.1 @apmaxoqunamwann ceolicrsa @apmaxorepanentaaua rpyma: HixnOuropa Ha TpomOouMrara arperaivis, ¢ IKMOUeHHE Ha xenapun, ATC Koa: BO1ACO6 Mexanvsy a nelierene Aulerancanmysmosara KHCeAMHa Namanaba OOpasyBaHeTO B MSCTOTO Ha BLANANeHMe Ha NpeKypcopHTe Ha Mpocrarsanaunn W TPOMGOKcaHH NocpenCTBOM AMpeKTHA MIKHOMUHK HA CHSHMA IMKNOOKCHTeHaZa. Enionpemenno ¢ Tosa crumynupa oraenaneTo Ha P-eHnopHnn, NoTHcKa cHHTe3a Ha exAOTeHHH ‘rrorenu u nouioxasa npara Ha Bta6yqHNOCT B TanaMyca. HaManaBa npoBeZsaHeTO Ha GONKOBH eKCTepO- MuTepouenmupin awmysten B LHC. Oxasea ecpexr Bspxy xHnoTanamyca H NoTucka opMupareTo Ha ‘engoren rmaporesm. Papmaxonunawnann ederra Tipiexcna s nest os Mexay 0,3 u 1,0 g oxasea Temneparypononasamo eHeTBHe H Ma HapaseHt anaureraien etext npH Gonka, npomBKoXAaUIA OT eKcTepoltemTHBHHTe penentropH. [Ipitexxaza 1 HspaseHo npoTHBoBLsKaNHTeAHO ACHiCTaHe, NpHIOXCHA B AHEBHN 03H 4-8 g. AueTHncamHuToBaTa KHCeIMHa HEXHGHDA TpoMOOUMTHaTa arperayna, GOKMpAiiKH cMHTesa Ha ‘TPOMGoxcaH A2w Tax. Expexrst e sau, Toil KATO TpOMOOLNTHTe He MoraT NA pecHHTTeSHpar TOsH ‘eHBHM, AnTHarperaHTTHWaT edbext © Hali-CHHO HapaseH MPH MpHEN Ha IHeBHH OSH 75-3 7 52 @apmaxoxuneraunu cnoiiersa A6copiunaAveTiuicamunsiosata KHcenHHa ce pesop6upa 65p30 H MMBIHO B racTpo-MHTecTHHA:HHA TpakT C7iey nepopastio npraoxerne. Mo Bpeme 4 cen pesopSyuaTa ce KOMBepTHpa B CBOA OCHOREH MeTAGOMHT camHyHOBa KHCeNHia, MakcHMalIHl Muia3MeHA KOHMCHTPALIMH, AeTHACATMURIOBATA KHCENMH® AOCTHTA 10-20 asym cnea npvema, a canuuwnonara kHcemmua — 0,3-2 vaca cney mpuema. Xpakiara He NoBnusaa SHonamrmocrra Wa aleTHNcanMMIOBATA M CaTHLUATORA KHCeNHHA, HO 3a6aBN pesopOUNTa. eH AneTiuicamumiozaTa H camMyobaTa KHCeAHEA ce CBDPSBAT Jmpano H B SHAAATENTHA CTeLeH C asMenurre nporestn (50-80%), pasnpenenet ce Gupro & TENECHHTE TEKAHH H TeYHOCTH. Buotpanchopmauys Auierinicanmnnopata KHcesmHA ce enuminHpa nocpesIcTBOM sepHompoBext MeTaGONHSEM, KATO oSpaaypannre meraGOnMTH ca carIMUVLINHKONHa KHCENHA, CANHIDAN eHOsIOB NMOKYPOHN, FeHTHBHHORA xvcenma W rermirsMuniaxosna Kicemuita. MeraGomHpa ce rnapiio OT HepHOApOBITHTe CoTepagH pe XHAPONH3@ HB NlO-MalIKa CTeTeH B TulasMaTa H epHTpouTHTe. EcrepasHara akTHBHOCT e HAMaIeHa MPH NepHompoGHu 3aGonaBaHMA H AIKOXONH3EM. Enuuuupave Kunervixara Ha eMMMHupavie Ha canHUsOBaTA KHceMHHa MOKASBa 3ABHCHMOCT OT NPHAOKeHaTa 11028, Topagu Topa Ye MeTaSontsMBT Ce AHMCTHPA OT KaNAUIITeTa Ha wepHOAPOOHUTe EHSHMH. BpEMETO Ha onyaxuBor © Mexny 2 H 3 waca c7ea MpHeM Ha HUCKH OSHC K No OKONIO 15 HCA MPH MPHEM Ha BACOKH ‘oat. Canviuutopara KucemmHa 1 Heine MeTaGOAMTA Ce EXCKPETUPAT TNABHO ‘pes KHOMepyTHa ‘pumrpaiuis, axrapua TySyaHa cexpewas u nacunna Ty6ymva peaGcopGuns. Ankannsnpariero Ha ypunara oA so Yenuapane Ha ypHMHaTa eKCKPENHS, CANHURLIORATA KUCEMHHA Ce OTKPHBA R KBPMETA H npewmuana npes naauexrara, $3 Tpemcamuuanu gaunn a Geronacuocr Croiiocture na LDso 3a aueracanmcionata KncemHHA Cen MepopanHO MpHIOMCHHE ca CROTBETHO Minutes - 250 mg/kg m urexone - 200 mg/kg. TIpx npomysokwTens0 MHOToKpatiio AosHpanle ce YeraHoBABaT MpoMeH B GEOpesHH NapeHxHM H Tacrpo- wirrectuHamnara murapHua. Hana aaunu sa yraretia axrusioct H KanueporenHo nelierBKe. isa ani 3a en6pHoroKcriso H teparorenno zelicrane— ASA nosiH 20 nosKuleH 6poll heryciH PevopSUNH, rPEGHANHO-MoSEAEN CYPH, HeaATBAPAHe Ha TEEPAOTO HeOUe, ManKpopMALIH Ha apewxumsin oprast. 6. @APMAUEBTHUHH JAHBK 6.1 Crepe na noMoutmre Bemecraa Apo na mabremxama: Muxpoxpacramia nemynosa Hamecre, npexenaTiitsupaHio ‘Cuutaunes aHoKcH, KOTOHNIEH GesBoneH (Creapmiosa xncomuta Puamoco noxpumue: ‘Onazpaii 03K 19229 knmap (xempoMencas, ‘puaeratt, TAK)‘Axpi-EZE 93A18597 Gan (eunonuMep wa Meraxpwiozata kHcesMHa—erHaxp#aar (1:1), TANK, THTAHOB AWOKEHA, CHTHIWER AHOKCHA, KOTONAEH Gessonlen, HaTpHeR SuKapONsT, HaTpHes Aaypuacynda), ‘Tpuerun unTpaT, MpesucTeHa BORA 6.2 Hecssmecrumocra Henpunorkamo. 63 Cpox na roanocr 3 rome. 64 Cuennaanm yeronns na coxpanesie Fla ce eexpanasa nos 25°C. 65 Bux n cuanpxanne na onaxonKara Tropaiuna onaxosia—no 10 Ta6serkx B GncTep or PVC/ anymnsteno ‘posto. Bropuma omaxoexa — no 4 Gnucrepa b crbaaeMa Kapronena KYTHR. 66 Cueunasun npeanasnd Mepku Mpa HaxEpasue paGora Hewsnoassanuar nexaporsex NpOAYKT WIM OTHARLHETE MATepHANH OT Hero TpAORA Ja Ce HOXRUPART B CuOTBETETBHE ¢ MECTHETe HOHCKBAHIA, 7. TIPATEXKATEJI HA PA3PEMIEHHETO 3A YHOTPEBA Xmuaxe apa EOD, ya. “Topuua”Ne 8A, 1618 Copus, Buorapus 8 HOMEP HA PA3PEIUEHHETO 3A YIOTPEBA Per, Ne 20150051 9. ATA HA ITbPBO PA3PEMIABAHE / IOJHOBSIBAHE HA PA3PEMIEHHETO 34 YOOTPEBA Zara wa mppo paspettanane: 23.02.2015 ava na nocaeauo noanosasane: 10. ATA HA AKTYAJIN3HPAHE HA TEKCTA Hoenspx 2019 r.