1.

NAMA OBAT : Buclizine

 STRUKTUR SENYAWA

N
Cl

 SIFAT FISIKA KIMIA

Boiling Point: 1004,56 [K]
Melting Point: 610,06 [K]
Critical Temp: 976,7 [K]
Critical Pres: 13,04 [Bar]
Critical Vol: 1297,5 [cm3/mol]
Gibbs Energy: 769,24 [kJ/mol]
Log P: 7,44
MR: 133,79 [cm3/mol]
Henry's Law: 9,35
Heat of Form: 257,67 [kJ/mol]
tPSA: 6.48
CLogP: 8.059
CMR: 13.4004
LogS: -7.662
pKa: 3.022, 8.364

 NAMA IUPAC
1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine

 PREDIKSI MR DAN ELEMENTARY ANALYSIS

Chemical Formula: C28H33ClN2

Exact Mass: 432,23
Molecular Weight: 433,03
m/z: 432.23 (100.0%), 434.23 (32.2%), 433.24 (30.7%), 435.23 (9.9%),
434.24 (4.5%), 436.24 (1.5%)
Elemental Analysis: C, 77.66; H, 7.68; Cl, 8.19; N, 6.47

 STEREOCHEMISTRY
 N

N
Cl

2. NAMA OBAT : promethazine

 STRUKTUR SENYAWA

 SIFAT FISIKA KIMIA

Boiling Point:
Melting Point:
Critical Temp:
Critical Pres:
Critical Vol:
Gibbs Energy:
Log P: 3,9
MR: 86 [cm3/mol]
Henry's Law: 3,79
Heat of Form:
tPSA: 6.48
CLogP: 4.5998
CMR: 8.8851
LogS: -4.777
pKa: 9.287

 NAMA IUPAC
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine

 PREDIKSI MR DAN ELEMENTARY ANALYSIS

 Chemical Formula: C17H20N2S
Exact Mass: 284,13
Molecular Weight: 284,42
m/z: 284.13 (100.0%), 285.14 (18.6%), 286.13 (4.5%), 286.14 (1.9%), 285.13 (1.5%)
Elemental Analysis: C, 71.79; H, 7.09; N, 9.85; S, 11.27

 STEREOCHEMISTRY

3. NAMA OBAT : Chlorpromazine

 STRUKTUR SENYAWA

N Cl

 SIFAT FISIKA KIMIA

 Boiling Point:
Melting Point:
Critical Temp:
Critical Pres:
Critical Vol:
Gibbs Energy:
Log P: 4,24
MR: 90,51 [cm3/mol]
Henry's Law: 2,94
Heat of Form:
tPSA: 6.48
CLogP: 5.4996
CMR: 9.3765
LogS: -5.397
pKa: 9.691

 NAMA IUPAC
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine

 PREDIKSI MR DAN ELEMENTARY ANALYSIS

Chemical Formula: C17H19ClN2S

Exact Mass: 318,10
Molecular Weight: 318,86
m/z: 318.10 (100.0%), 320.09 (32.0%), 319.10 (18.4%), 321.10 (5.9%), 320.09 (4.5%), 320.10 (1.6%),
322.09 (1.4%)
Elemental Analysis: C, 64.04; H, 6.01; Cl, 11.12; N, 8.79; S, 10.05

 STEREOCHEMISTRY

N Cl

4. NAMA OBAT : Brompheniramine

 STRUKTUR SENYAWA
 Br

 SIFAT FISIKA KIMIA

Boiling Point: 755,88 [K]
Melting Point: 483,75 [K]
Critical Temp: 853,11 [K]
Critical Pres: 24,24 [Bar]
Critical Vol: 838,5 [cm3/mol]
Gibbs Energy: 498,74 [kJ/mol]
Log P: 4,04
MR: 83,32 [cm3/mol]
Henry's Law: 8,05
Heat of Form: 209,39 [kJ/mol]
tPSA: 15.6
CLogP: 3.298
CMR: 8.4534
LogS: -3.902
pKa: 9.763

 NAMA IUPAC
3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine

 PREDIKSI MR DAN ELEMENTARY ANALYSIS

Chemical Formula: C16H19BrN2
Exact Mass: 318,07
Molecular Weight: 319,24
m/z: 318.07 (100.0%), 320.07 (97.4%), 321.07 (17.6%), 319.08 (17.5%), 320.08 (1.4%), 322.08 (1.4%)
Elemental Analysis: C, 60.20; H, 6.00; Br, 25.03; N, 8.78

 STEREOCHEMISTRY

Br

5. NAMA OBAT : Dimetindene

 STRUKTUR SENYAWA

 SIFAT FISIKA KIMIA

Boiling Point: 801,77 [K]
Melting Point: 517,01 [K]
Critical Temp: 859,46 [K]
Critical Pres: 18,66 [Bar]
Critical Vol: 944,5 [cm3/mol]
Gibbs Energy: 597,26 [kJ/mol]
Log P: 3,65
MR: 93,68 [cm3/mol]
Henry's Law: 7,83
Heat of Form: 228,48 [kJ/mol]
tPSA: 15.6
CLogP: 3.533
CMR: 9.3288
LogS: -3.659
pKa: 9.722

 NAMA IUPAC
N,N-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)-1H-inden-2-yl)ethan-1-amine

 PREDIKSI MR DAN ELEMENTARY ANALYSIS

Chemical Formula: C20H24N2
Exact Mass: 292,19
Molecular Weight: 292,42
m/z: 292.19 (100.0%), 293.20 (21.9%), 294.20 (2.3%)
Elemental Analysis: C, 82.15; H, 8.27; N, 9.58

 STEREOCHEMISTRY
 N

(E)