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Lecture 11 Incompatibility PDF
Lecture 11 Incompatibility PDF
When the substances with low melting points such as camphor, menthol and thymol are
mixed together, a liquid mixture i.e. eutectic mixture is formed and this process is
known as liquefaction.
2. Exit of crystalline water: By mixing hydrated crystals and dry crystals, crystalline
water diffuse to dry crystals.
Examples:
Camphor ,menthol, phenol, thymol ,chloral hydrate, sodium salicylate,Aspirin ,
phenazone.
Methods Of Rectifying Liquefaction:
By the use of absorbent like kaolin, light magnesium carbonate.
24 PHR 416 12/23/2013
4. Precipitation
Precipitation can result when the solvent in which the solute
is insoluble is added to the solution. Resins are normally not
soluble in water. So, the tinctures of resins may form
precipitate on addition to water.
1. Tolerated
In this type of incompatibility, chemical reaction can be
reduced by mixing the solution in dilute forms or by
changing the order of mixing.
2. Adjusted
In this type of incompatibility, change in the formulation is
needed with a compound of equal therapeutic value e.g. in
the mixture of caffeine citrate and sodium salicylate, caffeine
citrate is replaced with caffeine.