An impaired number of haploid chromosomes is a damaged or weak chromosome which

caused homologous chromosomes to fail to separate during meiosis 1 that reducing the diploid
cell to haploid. Meiosis is a cell division process that produces sperm or eggs, often known as
gametes. The resultant gametes do not have the same genetic makeup as the parent cell.
Gametes are haploid cells, meaning they only have half the DNA of their diploid parents.

An impaired number of haploid can be called aneuploidy, the state of possessing a

chromosome number that is not an exact multiple of the haploid number. Chromosome
abnormalities arise when an additional chromosome is lost or duplicated, resulting in an
impaired number of haploid chromosomes. Turner syndrome, Down syndrome, Trisomy 18,
Trisomy 13, Klinefelter syndrome, XYY syndrome, Turner syndrome, and triple X syndrome, are
all examples of aneuploidy. This occurs when the chromosomes do not fully divide during
sperm or egg production.

Nondisjunction is defined as the failure of homologous chromosomes or sister chromatids to

split during meiosis, resulting in an aberrant chromosome number. Nondisjunction can happen
during either meiosis I or II. The majority of abnormal human chromosome numbers cause the
growing fetus to die, frequently before a woman even realizes she is pregnant. In addition, a
chromosomal fragment can be duplicated or deleted in addition to the loss or gain of a
complete chromosome. Duplications and deletions frequently result in offspring who live but
have physical or mental defects..

In conclusion, when gametes have an abnormal amount of haploid chromosomes, it might

cause difficulties with the offspring's growth, development, and function such as . Turner
syndrome, Down syndrome, Trisomy 18, Trisomy 13, Klinefelter syndrome, XYY syndrome,
Turner syndrome, and triple X syndrome. These modifications can take place during the
creation of reproductive cells (eggs and sperm), throughout early fetal development, and on
any cell after birth. They are caused by nondisjunction, which occurs when pairs of homologous
chromosomes or sister chromatids fail to separate during meiosis.