Professional Documents
Culture Documents
JAMDA
journal homepage: www.jamda.com
Original Study
a b s t r a c t
Keywords: Objective: To compare the efficacy of acupressure with sham acupressure in older-adult nursing home
Alternative therapy residents presenting with poor sleep quality and psychological distress.
sleep quality Design: Prospective, randomized, double-blind, sham-controlled trial.
psychological distress
Setting and participants: Sixty-two nursing home residents with poor sleep quality and psychological
residential facilities
distress participated in this study. Participants were randomly assigned to an experimental group (n ¼ 31)
older adults
receiving acupressure at true acupoints (Baihui, Juque, Neiguan, Tianzhu, and Yongchung) or control group
(n ¼ 31) receiving acupressure at sham points. All participants received 20 minutes of acupressure before
sleeping 3 times a week for 8 weeks. All participants were blinded to group allocation.
Measures: Sleep quality and psychological distress were measured using the Pittsburgh Sleep Quality
Index and the Kessler Psychological Distress scale, respectively. Both groups’ outcomes were assessed by
assessors blinded to group allocation at the baseline, the end of the intervention, and 1 month after the
intervention.
Results: The experimental group demonstrated significantly more improvement in sleep quality than did
the control group at the end of the intervention (10.5 vs 13.3) and 1 month after the intervention (8.3 vs
14.2; both P .001). Moreover, the experimental group had lower psychological distress levels than did
the control group at 1 month after the intervention (14.6 vs 17.9, P ¼ .05). Furthermore, significant
differences in mean sleep quality (F ¼ 60.8, P < .001) and psychological distress (F ¼ 24.6, P < .001) were
observed in the experimental group between the measurements at baseline and after the intervention.
Conclusions: Acupressure at true acupoints improves sleep quality, reduces psychological distress, and
provides more clinically beneficial effects compared with that at sham points. Future studies should
examine whether these effects are maintained in the long term.
Ó 2019 AMDA e The Society for Post-Acute and Long-Term Care Medicine.
https://doi.org/10.1016/j.jamda.2019.01.003
1525-8610/Ó 2019 AMDA e The Society for Post-Acute and Long-Term Care Medicine.
I.-H. Chen et al. / JAMDA 20 (2019) 822e829 823
concern; for instance, the total annual insomnia-related costs incurred force. The posttest and follow-up test were conducted at the end of
in the United States is approximately $100 billion.6 In nursing homes the intervention (T1) and at 1 month after the intervention (T2),
(NHs), sleep medication is often prescribed to reduce insomnia in respectively. The study flow is presented in Figure 1. Neither the
residents. Approximately 15% to 41% of NH residents have a long participants nor the 2 outcome assessors knew the group allocation.
history of taking sleep medication.7,8 Although medication may The research assistants who implemented the interventions knew
rapidly alleviate poor sleep quality, it often has significant side which group each participant belonged to but were blinded to all
effects, such as falling, dependency syndrome, confusion, daytime measurements at the baseline and follow-ups; furthermore, they
drowsiness, and cognitive impairment.2,9 were not permitted to inform participants of this or interact with
The causes of insomnia in older adults include various medications them in any way.
as well as medical and psychiatric illnesses.10 Psychological distress is
highly and bidirectionally correlated to insomnia in older adults.11,12 In Participants
particular, older adults living in LTC settings exhibit an increased risk
of psychological distress, such as anxiety, anger, loneliness, and social To be eligible for participation, individuals were required to meet
isolation.13e15 These risks are evidenced by high prevalence rates of the following criteria: age of 65 years; living in an NH for at least
psychological distress among NH residents of up to 85%.13,16 Psycho- 3 months; ability to communicate with the research teams; normal
logical distress, a psychological disease,17 may be a crucial factor un- cognitive function (ie, a Mini-Mental State Examination score of
derlying the sleep problems of NH residents. Accordingly, the safer 25)30; a C-PSQI score of >531; a K-10 score of 2232; and absence of
approach of nonpharmacologic intervention designs for reducing any problems, such as a fracture, ulcer, skin disease, or inflammation,
insomnia and psychological distress among NH residents would be of at the locations of the pressure points. Individuals were excluded if
great value. they presented with major organ failure, tuberculosis, burns, tumors,
Although interventions using physical activities, social activities, injuries, hemorrhagic disorders, or local infections. Participants were
bright lights, and music to reduce sleep problems among NH residents not excluded for using hypnotics or antidepressants, provided that the
have been developed,18e21 those focusing on insomnia and psycho- dose was stable over the 6 weeks before the start of the trial. Sample
logical distress among NH residents are lacking. Acupressure, a com- size calculations were based on previous C-PSQI research.33 A sample
plementary therapy, has attracted attention as a strategy for size of 60 participants was required to verify significant intervention
improving sleep quality or reducing psychological distress22,23 and effects at a statistical power of 80% at the end of an 8-week inter-
potentially has no associated side effects.23 vention, a significant level of 0.05, 2-sided, a medium effect size of 0.5,
Acupressure is a massage technique in which a certain amount of and a presumed dropout rate of 10%. In total, 62 residents participated
force is applied using the fingers and palms to stimulate acupoints in this study (Figure 1).
along the meridian lines on the surface of the skin to open block- During the study period, participants were requested to not
ages.4,24,25 According to traditional Chinese medicine, an acupoint is a practice other forms of intervention for promoting sleep or reducing
location where qi and blood from the viscera and meridian infuse into psychological distress (eg, tai chi and mindfulness practices); more-
the body surface.26,27 The diameter of each acupoint is 0.3 to 1.2 cm. over, a physician with a license for traditional Chinese medicine
Meridians constitute unique pathways for the circulation of qi and reviewed participants’ medical statuses and medications each week. If
blood, connecting the organs and extremities and linking the exterior changes were observed in a participant’s medical status (eg, unstable
with the interior and the upper with the lower parts of the body.28,29 chronic illness or infection around the acupoints) or medications (eg,
Balanced energy (yang and yin) can help maintain health and prevent new hypnotic type or dose) that could influence the results, then the
diseases.28 The disruption of this network by blocked meridians af- physician would inform the PI, who decided whether the participant
fects overall health. The current study investigated the effects of should be withdrawn from the study. One researcher collected data on
acupressure on sleep quality and psychological distress in older NH medication changes from medical records each week. During the
residents, with the hypothesis that acupressure improves sleep entire research period, no changes in the medical statuses or medi-
quality and reduces psychological distress. cations of participants were observed.
Methods Interventions
Study Design The researchers and a senior licensed Chinese medicine expert
with clinical acupressure experience selected the acupoints for the
This study was approved by the ethics committee of the university interventions and developed the instructions. Interventions were
of the principal investigator (PI). Moreover, an NH in Central Taiwan administered by 2 assistantsdone for the experimental group and
provided permission to conduct this study at the NH. This was a the other for the sham-controlled group. These assistants had
double-blind, randomized, controlled trial with repeated measures. received 62 hours of training in the concepts of acupressure as well
Written consent was obtained from participants after the researchers as in true acupoint and sham point identification and acupressure
had fully informed them of the details of the study. skills (eg, implementing uniform pressure in a rotary motion with
Before group assignment, participants took a pretest assessing the pressure on the tips of the fingers) from the senior Chinese
their sleep quality by using the Chinese version of Pittsburgh Sleep medicine expert, who repeatedly confirmed the accuracy of the
Quality Index (C-PSQI) and their psychological distress by using the implementation. Before the experiment, the PI used a platform scale
Kessler Psychological Distress scale (K-10)dthe results of both of of 0.02 to 6 kg to measure the force of the finger pressure applied by
which constituted the baseline values (T0). A random distribution the assistants to ensure intrarater reliability. To pass this test, correct
was used to assign participants to an experimental group (n ¼ 31) pressure was required to be achieved 9 of 10 times. The reliability of
and control group (n ¼ 31). A statistician not involved in the study the pressure level was confirmed after 50 practice trials with a mean
randomly allocated participants into the acupressure or the sham of 3.4 to 4.9 kg on the scale for both hands of the assistants. The
group using a computer software program that generated the experimental group received acupressure and usual care, whereas
random sequence. The sequence was concealed until assignment was the control group received sham acupressure and usual care. The
completed. Both groups accepted interventions at bedtime 3 times a true and sham acupressure protocols were the same, with the only
week for 8 weeks; each session was of 20 minutes, involving 3 to 5 kg difference being the selected acupoints. The interventions were
824 I.-H. Chen et al. / JAMDA 20 (2019) 822e829
distress.4,28,29,34 Baihui (governing vessel 20) is located at the inter- (Figure 2E). Each of the 5 selected acupoints on the bodies of the
section of the line connecting the apexes of the 2 auricles and the participants were treated for 4 minutes in every session. Acupressure
median line of the head (Figure 2A). Juque (conception vessel 14) is on for an interval of 3 seconds with a feeling of soreness, numbness,
the midline between the umbilicus and sternum (Figure 2B). Neiguan distension, and ache (de qi) was followed by 3 seconds of rest.
(pericardium 6) is on the palmar side of the forearm, approximately
the width of 3 middle fingers up from the wrist line, between the Sham Acupressure
flexor carpi radialis and palmaris longus tendons (Figure 2C). Tianzhu
(bladder 10) is within the posterior hairline in the trapezius muscle The control group received sham acupressure at nonacupoints.
(Figure 2D). Yongchung (kidney 1) is on the sole of the foot, in the Nonacupoints were 0.5 cun (half width of the thumb) away from the
depression that forms when the foot is in plantar flexion, at the targeted active acupoints and avoided being on the same meridian as
junction of the anterior one-third and posterior two-thirds of the line the true acupoint. Acupressure was performed for intervals of 3 sec-
connecting the base of the second and third toes with the heel onds followed by 3 seconds of rest at the same frequency as it was
826 I.-H. Chen et al. / JAMDA 20 (2019) 822e829
Variable Experimental Control Group c2 P Demographic data were compared using a c2 test and Fisher exact
Group (n ¼ 31) (n ¼ 31) Value test. If significant results were produced, a post hoc test with the Sidak
Frequency % Frequency % correction was used to assess pairwise comparisons of the C-PSQI and
K-10 within a group. Independent t test was used to compare the
Gender 1.2 .3
Male 12 38.7 8 25.8 mean C-PSQI and K-10 scores between the 2 groups. Data were
Female 19 61.3 23 74.2 analyzed using PASW (version 22.0 for Windows; SPSS, Chicago, IL).
Age, y 2.1 .6 All statistical tests were 2-tailed; a P value of <.05 was considered
65-70 7 22.6 3 9.7
statistically significant.
71-75 8 25.8 8 25.8
76-80 5 16.1 7 22.6
81 11 35.5 13 41.9 Results
Education 3.0 .4
Uneducated 7 22.6 3 9.7 Both groups comprised more women than men. Those aged
Primary school 12 38.7 18 58.1
81 years, who had a primary school education, who were widowed,
Junior high school 8 25.8 7 22.6
Senior high school 4 12.9 3 9.7 who had experienced cardiovascular accidents, and whose children
Marital status 5.5 .1 paid the expenses for living at the NH constituted the highest pro-
Married 4 12.9 1 3.2 portion in both groups (Table 1). No significant differences were
Divorced 3 9.7 0 0
observed between the demographics of the 2 groups. Furthermore, no
Widowed 23 74.2 29 93.5
Unmarried 1 3.2 1 3.2
participant reported any adverse effects of the intervention (eg,
Source of funding 1.0 .6 dizziness, headache, muscle ache, or muscle cramps).
Government 1 3.2 2 6.5
Children 26 83.9 27 87.1 Group Comparisons
Self-pay 4 12.9 2 6.5
Medical condition 5.7 .8
Heart disease 0 0 2 6.5 No significant differences were observed between the experi-
Hypertension 7 22.6 7 22.6 mental and control groups at T0 for sleep quality (t ¼ 1.5, P ¼ .1) or
Diabetes mellitus 10 32.3 9 29.0 psychological distress (t ¼ 1.6, P ¼ .1; Table 2). A significant differ-
Cardiovascular accident 10 32.3 10 32.3
ence in global C-PSQI scores was observed between the experimental
Mental disease 4 12.9 3 9.7
Medications taken 5.0 .4
and control groups at T1 (t ¼ 5.2, P < .001). However, a nearly sig-
None 11 35.5 9 29.0 nificant difference was observed between the experimental and
Hypnotic drugs 5 16.1 5 16.1 control groups regarding K-10 scores (t ¼ 2.0, P ¼ .054). At T2, the
Cardiovascular drugs 10 32.3 11 35.5 global C-PSQI and K-10 scores significantly differed between the
Antidepressant drugs 5 16.1 6 19.4
experimental and control groups (t ¼ 11.5, P < .001 and t ¼ 2.00,
P ¼ .05, respectively). As for the components of the C-PSQI, significant
differences in sleep latency, sleep duration, habitual sleep efficiency,
and sleep disturbance were noted between the experimental and
performed in the experimental group. According to traditional Chi-
control groups at T1 and T2. Furthermore, significant differences in the
nese medicine, the manipulation of nonacupoints should not produce
use of sleep medications and sleep sufficiency were observed between
a feeling of de qi.
the experimental and control groups at T2 (Table 2).
Acupressure Evaluation
Measures
Global C-PSQI scores of the experimental group at T0, T1, and T2
Quality of Sleep differed significantly (F ¼ 60.8, P < .001). Sleep latency, sleep duration,
habitual sleep efficiency, sleep disturbance, sleep medication use, and
The C-PSQI is a self-rating questionnaire assessing sleep quality, sleep sufficiency scores on the C-PSQI in the experimental group
with a total score range of 0 to 21. The individual 19 items are used to exhibited significant differences at T0, T1, and T2 (Table 2). K-10 scores
generate 7 component scores: subjective sleep quality, sleep latency, of the experimental group differed significantly at T0, T1, and T2
sleep duration, habitual sleep efficiency, sleep disturbances, use of (F ¼ 24.6, P < .001). Although scores for psychological distress in the
sleep medications, and sleep sufficiency. Items are scored from 0 (no control group exhibited a decline during treatment, the differences
difficulty) to 3 (severe difficulty). A score of >5 indicates poor sleep were nonsignificant (Table 2).
quality.31 A global score of >5 on the C-PSQI yields a diagnostic
sensitivity of 98% and specificity of 55%.35 Cronbach’s alpha for the Discussion
scale was 0.82 in this study.
This study determined whether acupressure on the Baihui, Juque,
Neiguan, Tianzhu, and Yongchung points can decrease the occurrence
Psychological Distress of insomnia and the level of psychological distress. The findings of this
study suggested that acupressure can promote sleep quality and
K-10 is a 10-item scale for nonspecific psychological distress.32,36 reduce psychological distress in older-adult NH residents with
The measured dimensions include feelings of depression, restless- insomnia, who experience psychological distress.
ness, anxiety, hopelessness, and worthlessness. Items are scored from
1 (none of the time) to 5 (all of the time). The total score range is 10 to Effectiveness of Acupressure in Improving Sleep Quality
50. A score of 22 indicates worse levels of psychological distress. The
Chinese version of K-10 is reliable and valid.37 Cronbach’s alpha for the Before the intervention, older adults in both groups generally
scale was 0.89 in this study. experienced severe sleep problems (C-PSQI scores of >13), suggesting
I.-H. Chen et al. / JAMDA 20 (2019) 822e829 827
SD, standard deviation. The findings of this study should be interpreted with caution.
PSQI total scores ranged from 0 to 21, with lower scores being favorable. K-10 total
The study was limited to 1 NH and a sample size of 62 people;
scores ranged from 10 to 50, with lower scores being favorable.
therefore, the results cannot be inferred as valid in other settings.
828 I.-H. Chen et al. / JAMDA 20 (2019) 822e829
32. Kessler RC, Andrews G, Colpe LJ, et al. Short screening scales to monitor pop- 43. Bauer BA, Cutshall SM, Wentworth LJ, et al. Effect of massage therapy on pain,
ulation prevalences and trends in non-specific psychological distress. Psychol anxiety, and tension after cardiac surgery: A randomized study. Complement
Med 2002;32:959e976. Ther Clin Pract 2010;16:70e75.
33. Tsay S-L, Chen M-L. Acupressure and quality of sleep in patients with end-stage 44. Davidson P, Hancock K, Leung D, et al. Traditional Chinese medicine and heart
renal diseasedA randomized controlled trial. Int J Nurs Stud 2003;40:1e7. disease: What does Western medicine and nursing science know about it? Eur
34. Chang CH. The effects of acupressure on neck pain and neck range of motion J Cardiovasc Nurs 2003;2:171e181.
for patient with sub-acute and chronic neck pain. Master’s thesis. Kaohsiung 45. Kashefi F, Khajehei M, Ashraf AR, et al. The efficacy of acupressure at the
City, Taiwan, ROC: Fooyin University; 2007. Sanyinjiao point in the improvement of women’s general health. J Altern
35. Tsai P-S, Wang S-Y, Wang M-Y, et al. Psychometric evaluation of the Chinese Complement Med 2011;17:1141e1147.
version of the Pittsburgh Sleep Quality Index (CPSQI) in primary insomnia and 46. Kotani N, Hashimoto H, Sato Y, et al. Preoperative intradermal acupuncture
control subjects. Qual Life Res 2005;14:1943e1952. reduces postoperative pain, nausea and vomiting, analgesic requirement, and
36. Kessler R, Mroczek D. An Update on the Development of Mental Health sympathoadrenal responses. Anesthesiology 2001;95:349e356.
Screening Scales for the US National Health Interview Scales. Ann Arbor (MI): 47. Lane J. The neurochemistry of counterconditioning: Acupressure desensitiza-
The University of Michigan Institute for Social Research/Survey Research tion in psychotherapy. Energy Psychol 2009;1:31e44.
Center; 1994. 48. Trentini JF III, Thompson B, Erlichman JS. The antinociceptive effect of
37. Zhou C-c, Chu J, Wang T, et al. Reliability and validity of 10-item Kessler scale acupressure in rats. Am J Chin Med 2005;33:143e150.
(K10) Chinese version in evaluation of mental health status of Chinese popu- 49. Wu H-S, Lin L-C, Wu S-C, et al. The psychologic consequences of chronic dys-
lation. Chin J Clin Psychol 2008;16:627e629. pnea in chronic pulmonary obstruction disease: The effects of acupressure on
38. Chen M-L, Lin L-C, Wu S-C, et al. The effectiveness of acupressure in improving depression. J Altern Complement Med 2007;13:253e262.
the quality of sleep of institutionalized residents. J Gerontol A Biol Sci Med Sci 50. Jaussent I, Bouyer J, Ancelin ML, et al. Insomnia and daytime sleepiness are
1999;54:M389eM394. risk factor for despressive symptoms in the elderly. Sleep 2011;34:
39. Hsu CH, Yang ML. The effect of intimacy massage on reducing depression and 1103e1110.
anxiety in the institutionalized elders: A single subject design. J Nurs Healthc 51. Pak VM, Onen SH, Gooneratne NS, et al. Observation and interview-based
Res 2010;6:54e64. diurnal sleepiness inventory for measurement of sleepiness in older adults.
40. Cho Y-C, Tsay S-L. The effect of acupressure with massage on fatigue and Nat Sci Sleep 2017;9:241e247.
depression in patients with end-stage renal disease. J Nurs Res 2004;12:51e59. 52. Padmanabhan R, Hildreth A, Laws D. A prospective, randomised, controlled
41. Suen LK, Wong TK, Leung AW. Effectiveness of auricular therapy on sleep study examining binaural beat audio and pre-operative anxiety in patients
promotion in the elderly. Am J Chin Med 2002;30:429e449. undergoing general anaesthesia for day case surgery. Anaesthesia 2005;60:
42. Yang MH, Lin LC. Acupressure in the care of the elderly. Am J Nurs 2007;54:10e15. 874e877.