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Cancer in asian population is very aggressive especially who are Foreign-Borne asian and they

are usually affected with the lung cancer (NSCLC) and molecular targeted therapy is one effective way

to cure it in the early stages by identifying the mutation.

Thamimul Ansari Najumudeen

Department of Medicine, University of Georgia

MD3150E: Epidemiology, Biostatistics and Public Health

Dr. Ekaterine Cherkezishvili

October 9, 2021
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Individual paper should address a patient or population’s physical, psychological, or social

problem. Based on the problem develop specific clinical question (in PICO format), search and analyze

existing evidence and provide recommendation for public health or clinical practice. You need to analyze

at least 5 scientific articles including one systematic review/meta-analysis. I do not have specific

requirements for the size. However, I do expect at least the page for final paper.

Specific instructions of specific structural components of the final paper:

Abstract

Structured summary of all 4 basic components of the paper. Write this last, after all other parts

are ready.
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Cancer in asian population is very aggressive especially who are Foreign-Borne asian and they

are usually affected with the lung cancer (NSCLC) and molecular targeted therapy is one effective way

to cure it in the early stages by identifying the mutation.

Background: Cancer is a disease that can start on any part of the body if the cells divide

abnormally. Nearly 9.6 Million deaths occur only by cancer Globally[ CITATION WHO21 \l 1033 ]. One

common type of cancer that is affecting a large Foreign-Borne Asian population is lung cancer(Soo, et al.,

n.d.). Nearly millions of people die due to this type of cancer. Lung cancer in male is more aggressive.

People who are facing cancer are also facing financial, emotional and physical burden. Nearly 80% of the

cases are non small cell lung cancer (NSCLC). So here they usually go with the conventional approach

rather than developing a new drugs since this is time consuming process. Here a scientist named cetin

even conducted a experiment where they found that the female population is not affected much

compared to male population. So in an experiment that was conducted on 18,967 patients suffering

from early NSCLC during 1991 to 1999 shows a significant survival rate on women compared to

men(Soo, et al., n.d.). And in a experiment that was conducted during 1988 to 2003 shows that people

who are US-Born asians have higher risk towards this type of cancer(Oncol., 2017). And according to the

predictions of GCO the cases of cancers in asia might go as high as 29.5 million by the end of 2040.

Among this nearly half of the cases are avoidable. Usually the treatment for this illness is surgery and

these people are even having high risk of relapse and because of that they would be treated with

chemotheraphy. Molecular-targeted therapy is given to the patients who are in stage iv of this cancer.

With this new of treated there are some promising results. So here we identify the molecular target and

they would develp a Molecular targeted therapy. In this first we identify the tumor tissue and we

examine this tissue for the mutation so we can proceed with the therapy(Tan, 2021). The result of this

tissue examination will determine if a patient is eligeble for the treatment or not. Examples of patients

who cannot be eleigble for this treatment are smokers. Usually there are many mutations that are seen
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in this type of patients. Examples of mutations are ROS-1 Mutation, NTRK gene fusion etc. One type of

mutation that’s seen is BRAF mutation and this can be treated with the help of Dabrafenib (Tafinlar) and

Trametinib (Mekinist).

Methods: describe your search: databases used, your search terms, # of articles identified, # of

articles reviewed, how you selected your articles to include: (5 articles, only one systematic

review/meta-analysis) Developing new drug is expensive and it is time consuming as well so they are

usually treated with conventional approach.

Results: briefly describe the sources you reviewed and your main findings. Note: At least 5

articles should be reviewed to receive the credit. Literature dissection matrix should be filled and

submitted as an annex 1. Plagiarism rules does not apply to appendix A (You can use copy-paste, to fill

the table)

Discussion: Discuss strengths and limitations of the studies you reviewed. Provide your specific

recommendation for clinical or public health practice.

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References:

World Health Organization. (2021, September 21). Cancer. https://www.who.int/news-

room/fact-sheets/detail/cancer

Medscape.(2012, May 23). Asians vs Caucasians - Lung Cancer and Systemic Therapy.

https://www.medscape.com/viewarticle/763160_2

PubMed Central (PMC). (2017,July 17). Cancer medicines in Asia and Asia-Pacific: What is

available, and is it effective enough?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677966/

Tan, W. W., MD. Medscape. (2021, September 27). Non-Small Cell Lung Cancer (NSCLC)

Treatment & Management: Approach Considerations, Surgical Treatment, Radiation

Therapy. https://emedicine.medscape.com/article/279960-treatment#d12
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Appendix A

Literature Dissection Matrix1

  Study Design Variables

Random
assignment Primary
Author (all names), &/or Predictor
  Title, Journal Year Study Purpose Type selection Dependent Independent Variable
1          
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Literature Dissection Matrix2

  Subjects Data My additional

# Subject Source or Year data notes/areas for
  Subjects Characteristics Instrument collected Results limitations conclusions further research
1                
2                
3                
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5                
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8                
9                
10