University of "Ss. Cyril and Methodius" — Skopje FACULTY OF PHARMACY INFORMATION PACKAGE FOR THE STUDY PROGRAM ON THE FIRST AND SECOND CYCLE INTEGRATED STUDIES FOR THE MASTER OF PHARMACY INTRODUCED IN THE ACADEMIC YEAR 2009/2010 AND FOR THE CONDITIONS, CRITERIA AND RULES FOR STUDYING SKOPJE 20091 FACULTY OF PHARMACY - SKOPJE« MANAGEMENT AND ORGANIZATION Faculty Dean «Dr. Aleksandar Dimovski, full professor Faculty Vice dean * Dr. Kristina Mladenovska, associate professor Secretary + Katerina Anchevska Netkovska, master of law Faculty Board Dr. Aleksandar Dimovski, fill professor Dr. Kristina Mladenovska, associate professor Dr. Ljubica Shuturkova, full professor Dr. Lidija Petrushevska Tozi, full professor Dr. Aneta Dimitrovska, full professor Dr. Svetlana Kulevanova, fall professor Dr. Katerina Gorachinova, full professor Dr. Marija Glavash Dodov, associate professor Institutes 1. Institute of Pharmaceutical Chemistry - Department of Pharmaceutical Chemistry - Department of Biomolecular Sciences - Department of Clinical and Social Pharmacy 2. Institute of Appiled Chemistry and Pharmaceutical Analyses - Department of Inorganic Chemistry ~ Department of Organic Chemistry - Department of Analytical Chemistry - Department of Instrumental Methods - Department of Drug Analytics3. Institute of Pharmacognosy ~ Department of Phytochemistry - Department of Pharmacognosy - Department of Pharmaceutical botany 4. Institute of Pharmaceutical Technology - Department of Pharmaceutical Technology - Department of Biopharmacy 5. Institute of Applied Biochemistry ~ Department of Food and Nutrition - Department of Toxicology - Department of Biochemistry Centers, - Center for Drug Quality Control - National Center for Drug Information ~ Center for Continuous Education - Center for Biomolecular Pharmaceutical Analyses - Center for Poisoning Control = Center for Natural Products - Center for Pharmaceutical Nanotechnology Professional and administrative services Librarye« ACADEMIC STAFF AND ASSOCIATES ‘The undergraduate study program at the Faculty of Pharmacy is conducted by lecturers from the Faculty of Pharmacy and to a certain extent by lecturers from other faculties: The Faculty of Medicine, The Faculty of Mathematies and Natural Sciences, The Faculty of Sport, The Faculty of Phiology and The Faculty of Philosophy. Full professors = Professor Luibica Shuturkova, PhD = Professor Aleksandar Dimovski, PhD, MD ~ Professor Lidia Petrusheyska Tozi, PhD - Professor Katerina Gorachinova, PhD ~ Professor Svetlana Kulevanova, PhD Professor Suzana Trajkovic Jolevska, PhD Professor Aneta Dimitrovska, PhD + Professor Renata Slavevska Raichki, PhD + Professor Bilyana Bauer Petrovska, PhD Associate professors ‘Associate professor Zoran Kavrakovski, PhD = Associate professor Tatyana Penovska Kadifkova, PhD = Associate professor Diana Plasheska Karantfilska, PhD ~ Associate professor Rubincho Zareski, PhD = Associate professor Kristina Mladenovska, PhD Assistant professors = Assistant professor Rumenka Petkovska, PhD = Assistant professor Maria Glavash Dodov, PhD - Assistant professor Zoran Sterjev, PhD = Assistant professor Aleksandra Grozdanova, PhD - Assistant professor Goshe Stefkov, PhD = Assistant professor Katerina Ancevska Netkovska , PhDAssistants ‘Assistant Ana Poceva Panovska , MSci ‘Assistant Katerina Brezovska, MSci ‘Assistant Jasmina Tonic Ribarska, MSci ‘Assistant Maria Hiladnikova Bayro, MSci ‘Assistant Maya Simonovska Crearevska, Msci ‘Assistant Zorica Serafimovska, MSei Assistant Aleksandra Kapedanovska, MSci ‘Assistant Maria Karapandgova, MSci Assistant Tanya Petreska Ivanovska, MSci ‘Assistant Nikola Geshkovski, MSci Assistant Jelena Acevska, MSci ‘Assistant Nadica Matevska, MSci Assistant Natalia Nakov, MSci Assistant Lilyana Bogdanovska, MSei¢ EDUCATION AND TEACHING ACTIVITY What is ECTS? The central element of the reform of the educational and teaching process is the setting of new rules of studying and implementing the European credit transfer system (ECTS). The main purpose is to create a student who is creatively oriented towards studying, a mobile student, who will equally adapt to the European higher education system, an educated persona with a European spirit who will be enabled to work in the broad and free European space. This will be achieved by changing the technology of the approach towards studying, by setting flexible rules of studying and implementing ECTS, in which the student is the center of the educational process, the personnel and the organization are subservient to their needs. ECTS are developed by the European commission with the intent to provide procedures that guarantee academic recognition of studies, built on mutual trust of the higher education institutions, based on the following grounds: complete information about the study program; agreement between partnered institutions (domestic and foreign high education institution) and use of the credit units as an indicator for the extent of the student’s completed work in a given period during the studies. ECTS credits are a numeric value attributed to course units in order to describe the student’s ‘engagement necessary for their completion. They reflect the quantity of the work needed for every course unit parallel to the overall quantity of work required in order to finish the whole year of academic studies at the institution, ie. lectures, practical work, seminars, field work, private studies ete, ECTS is based on the overall engagement of the student and is not limited only to the contact classes. ECTS credits are more of a relative measurement of the student's engagement in mastering the study program. Considering the recommendations of the “ECTS guides” and manuals of the University of Ss. Cyril and Methodius, the reorganization of the study program of the Faculty of Pharmacy includes: an overall transition to a semester lecturing for all subject programs, bigger number of classes for individual activities, implementing new optional subjects, implementing new methods of studying: seminars, individual projects, homework, field work, theoretical practice, summer practice, etc., implementing new methods of assessment of the continuous studying and a transparent system of forming the final grade.Rules of studying ‘The rules of studying are regulated according to the Law for high education (Gazette of the Republic of Macedonia number 35/2008, 103/2008 and 99/2009), the Statute of the University Ss. Cyril and Methodius in Skopje (passed in December 2008) and the Rulebook of conditions, criteria and rules of studying (passed in September 2009) available at the web page of the Faculty of Pharmacy (www.ffukimdu.mk) and University owww.ukim.edu.mky The integrated study program contains the enrolment preconditions i.e. taking all exams {from the second to the tenth term. The preconditions determine the order for enrolment ice. taking the exams in every term. * To have knowledge of a certain subject is to successfully master predetermined obligatory and non-obligatory forms of education of the particular subject. The knowledge is evaluated by continuous grading. By continually grading, maximum 50 points are acquired and the teacher signs the subject in the index. The signature is valid for one year. The student is obliged to pass the exam by the next wintet/summer term. On the contrary, the course is to be retaken, ‘A credit for a particular subject means to successfully master all obligatory and non-obligatory forms of education predetermined by the program as well as getting a final grade for the subject both in the form and the index. With the final grading a maximum of 50 points is acquired % The student who, within the continuous grading acquires the sufficient number of points predetermined by the integrated study program for acquiring a subject grade, will be graded with a final grade in the form and index, in the first exam session. The final grade is formed according to the grading scale provided in the program. ‘The student who did no win the minimum points determined by the subject program and did no acquire a signature, is obliged to retake the particular subject. The student who is retaking the subject from a former term is able to simultaneously sign up for a subject which is precondition by the retaken subject, taking into consideration the quota ofthe maximum credit count allowed per semester. Subject enrollment by semester is done according to the table listed below, which contains the necessary preconditions for every subject within the study plan and program of the integrated master of pharmacy studies. These conditions constitute the accredited study program. The student takes the exams chronologically according to the study program. ‘The student verifies the semester with the teachers’ signatures, which confirms they fulfilled all obligations predetermined. A student who did not fulfill the obligations appointed by the study program for a certain subject is not allowed to take the exam, ‘ The student has the right to take the exams within the winter, autumn and summer exam session. Two dates are given for every subject in every exam session,‘ For every subject that, according to the program practice is exercised, a final practice is taken in the presence of the subject teacher. The final practice can be taken two times. ¢ The student has the right and duty to take on and defend the graduation thesis. The title and the thesis for the graduation thesis are suggested by the subject teacher, within the chosen discipline in accord with the student, The Dean, by suggestion of the student candidate, determines the mentor and the subject of the thesis, and forms a commission for grading and defending the graduation thesis. A successful defending brings 10 ECTS credits which makes a total of 300 ECTS credits. Defending the graduate thesis is done in front of a 3-member commission, one of which is the mentor. The mentor, in accord with the student, sets the date for the defending. The commission after the defending of the graduate thesis grades the student from 5 to 10. For a successfully defended graduate thesis, a special form is filled and is signed by the commission members. Exam sessions The student has the right to take the exams within the winter, autumn and summer exam session. Two dates are given for every subject in every exam session. Each time the student enrolls but does not show up on the exam in the particular exam session, it is taken into account that the student has used the right of a single attempt to take the exam and itis written “did not pass” in the exam form. Academic year, semester study + The academic year begins September 15" and ends September 14” the next year, divided into ‘two semesters, summer and winter. 4 The winter semester takes place from September 15* to December 31%, the summer semester from February 1* to May 15".Credit system coordinators Faculty credit coordinator ‘Aleksandar Dimovski, PhD tel. 3126-032 email: adimovski@ffukim.edusmk Institute credit coordinators * Ljubica Shuturkova, PhD, Institute for Pharmaceutical Chemistry email: Ijsu@)fukim.edu.mk Aneta Dimitrovska, PhD, Institute for Applied Chemistry and Pharmaceutical Analysis email: andi@ff-ukim.edu.mk Marija Glavash Dodov, DD, Institute for Pharmaceutical Technology email: magl@fEukim.edu.mk Svetlana Kulevanova, PhD, Institute for Pharmacognosy email: svku@f¥-ukim.edu.mk ‘Lidija Petrushevska Tozi, PhD, Institute for Applied Biochemistry email: ito@ff.ukim.edu.mk¢ APPLICATIVE ACTIVITES ‘The Institutes of the Faculty and other Departments, the National Center for giving Drug Information and. the Center for Drug Control and Examination have a rich applicable activity. The National Center for Drug Information produces proposal programs for rational medication ‘use, monitoring the use and consumption of medications, drug misuse, priority drug lists, newly registered drugs, continuous education of health workers, educating the population etc. The Center for Drug Control and Examination as an accredited laboratory authorized by the Ministry of Health, controls the quality of pharmaceutical-chemical ingredients, ready-made ‘medicines, auxiliary medicinal ingredients, imported products, special control of specific drug groups, and other examinations predicted by the law. The Faculty is a competent institution for making. toxicological tests for medicinal ingredients, poisons, pesticides, and other products, attesting herbal raw material quality, food products and other natural products. The Center for Biomolecular Pharmaceutical Analysis provides analytical and diagnostical services to health institutions in the country. The Center for Pharmaceutical Nanotechnology within the activities of scientific research and development projects deals with the development and testing of the bioavailability of nanosystems for targeted action of therapeutics and biotherapeuties, as well as the preparation of pharmaceutical dosage forms composed of million particles smaller than cells that fimction at the level of nanoparticle / receptor / cell interaction, bringing the active substance to the site of action.a. STUDY PROGRAM AND CONDITIONS FOR STUDYING ‘The Academic Program for integrated studies of first and second cycle for acquiring « specialized academic title of Master of Pharmacy is designed within the Tempus Project JEP-18016-2003 Reconstruction of the pharmaceutical education in the Republic of Macedonia” and is in accordance with the Law of High Education, with more precisely defined criteria published in the competition by the university $s. Cyril and Methodius in Skopje and the EU Directives on recognition of regulated professions [Directive 2005/36/EC of the European parliament and of the Council of 7 September 2005 1 European Communities (Recognition of Professional Qualifications) Regulations 2007 of 19% October 2007], as well as with the declarations of the European Association of Faculties of Pharmacy (EAFP) from: La Laguna 2004, Malta 2005, Tartu 2006 and Lille 2008.(si0a) yonves daen upp sate ae nt San oem (sie) von mee s10900) ciao (siagp ‘amo sao sonatorg s1o300 (sia) i" ‘Sximee 233) psi 0 jr verso, eS yous (sioa peso paper Sak (s1539) ray) soa0n sisap ‘dnp signs 2011 £ ‘sqooeasngg 2m omuoxeseecinorg | Gasuoup etn 258 (s1oa scot 1 Aden 50 (sna9) 1 Sasa ooo woaD a0. 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The evaluation is given on the basis of: * Participation in compulsory activities * A written project and an oral presentation of it. ‘Teaching material: NA Purpos The object of the course is to give the students an introduction to the curriculum of the Faculty of Pharmacy and to put the pharmaceutical education into perspective to the pharmaceutical profession. This course also contains introduction to security matters in laboratory courses and the rules and regulations of safe laboratory practice. Content: ‘The course consists of introduction to: = Pharmacy profession — multiple aspects of being a pharmacist = Ethics in Pharmacy practice = Meeting with different professionals within the pharmacy practice = Basic aspects of Social Pharmacy health system in Macedonia with special emphasis on the pharmaceutical sector 0 definition/concept of a drug O drug effects and side effects absorption, distribution, metabolism and excretion of drugs relation between chemical structure and biological effects ‘o pharmacoepidemiology 7 Development, production, distribution and quality assurance of drugs explain why different forms of drugs exist and when they are used o knowledge of the production of different forms of drugs ‘quality assurance and quality control O registration of drugs by the National Drug Agency structure and purpose of the European Pharmacopoeia - Introduction to Laboratory Safety with an orientation on harmful effects of the occupational environment with focus on the chemical effects ~ acute as well as long-term actions is given. Prevention and treatment of corrosions and burs are described together with an introduction to fire chemistry as an introduction to a fire extinguishing exercise, The security organisation of the university is presented.Student load: Hours: Lectures 26 Preparation for lectures 13 Meeting with professionals 10 Laboratory exercises 4 Preparation for exercises 4 Subtotal 37 Individual project (individual and group work) 53. Presentation of the projects, 10 Total 120 Course responsible: Prof. Biljana Bauer, Department of Pharmacognosy and Botany ~ biba@ff.ukim.edu.mkGeneral and Inorganic Chemistry Practical Information Code FFIHI9 Status: Compulsory ‘Time schedul 1* semester Teaching methods: Lectures + numerical and laboratory exercises Dimension of course: 8.0 ECTS Number of hours: 45 lectures of 45 min, 45 laboratory and numerical exercises of 45, minutes Frequency: Once a year Evaluation: Continuing: 50 points Final: 50 points ‘A student can pass the subject without a final exam if he/she collects at least 71 points throughout the semester with the following mark scale: 71-76 points — 6 77-82 points ~7 83-88 points ~ 8 89-94 points —9 95-100 pints - 10 Teaching mater Whitten K.W., Davis R-E., Peck M.L., Stanley G.G. Brooks/Cole, Belmond USA, 2004; Cotton F.A., Wilkinson G., Murillo C.A., Bochman M., Advanced Inorganic Chemistry, 6° Edition, Hohn Wiley & Sons, New York, 1999; Arsenijevic S.R., Hemija Opsta i Neorganska, 14 dopunjeno izdanje, Nauena knjiga, Beograd, 1994 GeneralChemistry, 7 Edition, Thomson Purpose: The objective of the course is to provide learning of fundamental concepts of chemistry and to develop student's numerical problem-solving skills. Subjects are chosen to provide leaning of basic chemical properties of the elements and the most common inorganic compounds. Special attention is paid to elements that participate in important biological processes and pharmaceutical relevant inorganic compounds. The course is the foundation of the following compulsory courses: analytical chemistry, organic chemistry, bioorganic chemistry and pharmaceutical chemistry. Pre~ requests: None Content: General chemistry: The lectures provide theoretical knowledge of general chemistry. The ‘numerical exercises with individual numerical problem solving are used to answer a variety of examples and exercises based on fundamental laws in chemistry. ‘The course include: Basic definitions and basic laws in chemistry; energy changes in chemical reactions, basic thermodynamic laws. The atomic theory of structure of the atoms, Quantum theory and electronic structure of atoms, Periodic relationships among the elements. Chemical bonding Chemical kinetics. Chemical equilibrium in aqueous solution (acid/base reactions, the pH concept, buffer solutions, redox reactions, complex formation).Inorganic chemistry: The periodic table and chemistry of the elements, Non-metallic elements and their compounds. General properties of metal elements and their common compounds. Transitien metal chemistry and coordination compounds. Outcome: The aim of the course is that the student obtains basic knowledge of fundamental concepts of chemistry with the outcome that student after passing the course + has a basic knowledge of structure of atoms, periodic properties of the elements and nature of chemical bonding; * has a basic knowledge of composition stechiometty (the quantitative relationship among clements in compounds) and reaction stechiometry (the quantitative relationship among substances as they participate in chemical reactions); * has @ basic understanding of the relation between structure and reactivity of simple molecules based on their electronic structure; is able to make calculations of simple as well as more complex problems based on fundamental laws in chemistry and chemical equilibrium in aqueous solution; * has a knowledge of basic chemical properties ofthe elements and the most common inorganic compounds; * has a basic knowledge of elements that participate in important biological processes and pharmaceutical relevant inorganic compounds. Student load: Hours: Lectures 45 Preparation for lectures 45 Laboratory and numerical exercises 45 Preparation exercises 25 Subtotal 160 Evaluation 80 Total 240 Course responsible: Prof. Rumenka Petkovska, rupe@ff-ukim.edu.mk Insitute of Applied Chemsitry and Pharmaceutical analyses, Faculty of PharmacyMathematics Practical Information Code FFDP28 Status: Compulsory Time schedule: 1* semester Teaching methods: Lectures, practicals (class hours), Dimension of course: S ECTS-points, Number of hours: 30 lectures of 45 min, 30 practicals of 45 minutes, Frequenc} Once a year. Evaluation: Continuing: 50 points Final: 50 points A student can pass the subject without a final exam if he/she collects at least 71 points throughout the semester with the following mark scale: 71-76 points ~ 6 77-82 points ~ 7 83-88 points 8 89-94 points ~9 95-100 pints — 10 ‘Teaching material: llievski B., Matematika za farmacevti, Skopje, 2001 Purpose: The objective of the course is to give the students knowledge about several fields of mathematics focusing on differential and integral equations which are implicated in the courses of Physics, Physical pharmacy and the laboratory exercises later in the studies. Pre ~ requests: None Content: Sets, maps and binary operations; Number sets; Mathematical induction and binomial formula; Ratio, proportion and percent; Some applications of percent and proportion in chemical problems; Sequences of real numbers: definition and some elementary properties; Some theorems for convergent sequences; Arithmetical, geometrical and natural sequences; Real functions of one real variable; Limit of functions; Limits of some more important functions; Differential calculus; Differentiation formulas for explicit functions; Derivative of implicitly and paramettically given functions; First differential of functions; Geometrical, physical and chemical interpretation of the derivative; Derivatives and differentials of higher order, Local extreme and Fermat's theorem; Lopital formulas for indefinite terms; Indefinite integrals; Newton - Leibnitz theoret plications of the definite integral; Real functions of two independent variables. Outcome: Upon completion of the course the students are expected to: ‘+ Demonstrate knowledge in several fields of mathematics important to the future pharmacist ‘* Be able to deal with mathematical problems related to differential and integral counting,Student load: Hours: Lectures 30 Preparation for lectures 30 Practicals (class hours) 30 Preparation for practicals. 15 Subtotal 105 Evaluation 45 Total 150 hours Course responsible: Prof. Borko lievski, Faculty of natural sciences and mathematicsBasic of Organic Chemistry Practical Information Code FFIH20 Status: Compulsory ‘Time schedule: 1" semester Teaching method: Lectures, practical Dimension of course: 7.0 ECTS-points, Number of hours: 40 lectures of 45 miutes, 30 practical of 45 minutes, 5 group work of, 45 min Frequency: Once a year. Evaluation: Continuing: 50 points Final: 50 points, A student can pass the subject without a final exam if he/she collects at least 71 points throughout the semester with the following mark scale: 71-76 points — 6 71-82 points —~7 83-88 points — 8 89-94 points —9 95-100 pints ~ 10 ‘Teaching material: McMurry J. Fundamentals of Organic Chemistry, 5" Ed,, Brooks/Cole, 2003 Peter K., Vollhardt C., Schore N. Organic Chemistry: structure and function, 4" Ed W. H. Freeman and Company, 2003 Carey F. Organic Chenmistry 4" Ed McGraw-Hill, 2002 Brown W. Organic Chemistry, International Edition, Harcourt Brace College, 1995 Purpose: The objective of the course is to give the students knowledge about the molecular structure of organic compounds including stereochemistry, classes of organic compounds, their physical properties and chemical reactivity Pre— requests: None Content: Structure and Bonding; Bonding and Molecular Properties; The Nature of Organic Compounds, Alkanes and Cycloalkanes; Stereochemistry of Alkanes and Cycloalkanes; An Overview of Organic Reactions; Alkenes: Structure and Reactivity; Alkenes: Reactions and Synthesis; Allkynes; Alkyl Halides; Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations; Structure Determination: Mass Spectrometry and Infrared Spectroscopy; Structure Determination: Nuclear Magnetic Resonance Spectroscopy; Conjugated Dienes and Ultraviolet Spectroscopy; Benzene and Aromaties; Chemistry of Benzene: Electrophilic Aromatic Substitution; Alcohols and Thiols; Ethers, Epoxides, and Sulphides; Aldehydes and Ketones: Nucleophilic Addition Reactions; Carboxylic Acids; Carboxylic Acid Derivatives and Nucleophilie Acil Substitution Reactions; Carbonyl Alpha-Substitution Reactions; Carbonyl Condensation Reactions; Aliphatic Amines; Arylamines and PhenolsOutcome: After finishing the course the student: Can account for systematic nomenclature and structures of different classes of organic compounds © Can account for pathways of preparation/synthesis of different classes of organic compound Can account for the physical properties and chemical reactivity and reaction mechanism © Can describe the structure of molecules, their conformation, molecular geometry and molecular isomerism ‘© Has obtained knowledge for isolation, purification and characterization of organic compounds and is able to handle the equipment and carry out basic operations in a safe manner in organic chem, laboratory Student load: Hours: Lectures 40 Preparation for lectures 40 Laboratory classes 30 Preparation 15 Group work 15 Subtotal 140 Evaluation 70 Total 210 hours Course responsib! Prof, Vaska Arsova Ass. Ana Poceva-Panovska Insitute of Applied Chemsitry and Pharmaceutical analyses, Faculty of PharmacyBiophysics Practical Information Code FFDP29 Status: Compulsory ‘Time schedul 1* semester Teaching methods: Lectures, tutorials, practical, Dimension of course: 6 ECTS-points. Number of hours: 30 lectures of 45 min, 30 practical of 45 minutes, group work 15 of 45 minutes, Frequency: Once a year, Evaluation: Continuing: 50 points Final: 50 points ‘A student can pass the subject without a final exam if he/she collects at least 71 points throughout the semester with the following mark scale: 71-76 points 6 77-82 points —7 83-88 points ~ 8 89-94 points 9 95-100 pints ~ 10 Teaching material « Stoimenov S., Lectures of Biophysics-Inter publication-PMF, Skopje (2005) + Tipller Physics World Publisher (1995) # Andonovska N., Biophusics, Skopje (1998) « Stojanov Z, Stoimenov S., Fizicki principi na ultrazvuznata dijagnostika i terapija MANU (2001) Purpose: Biophysics can generally explain how physical phenomena such as mechanics, electricity, magnetism, light, heat, and radiation affecVaccount for the structure and the function of biological systems. Biophysics covers a wide scope of problems related to the main physical mechanisms of processes taking place on different organization levels in biosystems. It includes structure and dynamics and cells and tissues; the influence of the environment; energy transformation and transfer; thermodynamics; biological motility; and cell differentiation modeling; biomechanic and tissue reology; cybernetic modeling of complex systems in human body. Pre — requests: None Content: Ambient from a point of view of Physics and Biophysics; Fundaments of Biocybernetics; Kinematics and Mechanics in Nature; Forces, and Centrifugal Systems; Locomotoric System of Men; Physics of Bone, Muscle and Joint; Pressure and Biological Systems; Atmospheric and Blood Pressure; Work and Power of Man and Heart; Physics and Biophysics of Fluids; Transport Phenomena in Living Organisms; Diffusion and Osmosis in Cell Membrane, Filtration; Heat and ‘Thermodynamics in Biological Systems; Humidity as a Biological Factor; Evaporation and Condensation; Bio Acoustics; Biomaterials; Bioelectricity; Bioelectric, Membrane’s and Action potentials; Magnetic and Electric Fields and Living Organisms; Light and the Optics of Vision; uPhotobiological Provesses and Mechanisms; Bioluminescence; Ionizing and Non Ionizing Radiation; Consequence and Safeguard of Radiation. Outcome: + Knowledge of the main physical principles and methods needed for explaining the bioprocesses. + Every organism must interact with its environment in order to obtain energy and substance, ‘+ Modelling and identification of bio systems. Moving in nature and biological systems. Work and power of men and heart, Biomechanics of fluids, Pressure, Viscosity, Tensioactivity, Capillarity, Sedimentation Life is an irreversible process. Bio energetic Temperature and Heat Life involves a temporary decrease of entropy for which energy is spent. Diffusion. Osmosis, Humidity. Evaporation, Filtration. Biophysics of hearing. Ultrasound. Equipment for diagnostics and therapy. Bioimplantant, New materials. Biomaterials. Electric current and living organisms. Therapeutic methods and equipment. Membrane’s Transport. Bio potentials. Na-K pump, ECG, EEG, EMG. Biophysies of vision. Physical phenomena, Optic instruments, fiberoptics. Lasers. Fundaments of Modem physics. Transmutation, Nuclear fusion and fission, Sources of radiation. Interaction of radiation and biomaterials. Radioisotopes in medicine. Measurement of radiation, monitoring and protections. Student load: Hours: Lectures 30 Preparation for lectures 30 Practicals 30 Preparation for practicals. 15 Group work 15 Preparation for group work 10 Subtotal 130 Evaluation 50 Total 180 hours Course responsible: Prof, Stanoja Stoimenoy, stanojas@iunona.pmf-ukim.edu.mk Institute of Physies, Faculty of natural scineces and mathematics 12Applied Statisties Practical Information Code FFDP30 Status: Compulsory ‘Time schedule: 2” semester Teaching methods: Lectures, practicals (class hours), Dimension of course: 3.5 ECTS-points. Number of hours: 15 lectures of 45 min, 30 practicals of 45 minutes, Frequency: Once a year. Evaluation: Continuing: 50 points Final: 50 points ‘A student ean pass the subject without a final exam if he/she collects at least 71 points throughout the semester with the following mark scale: 71-16 points — 6 77-82 points —7 83-88 points ~ 8 89-94 points ~ 9 93-100 pints — 10 Purpose: The objective of the course is toi roduce students into basic statistical parameters ant tests, Pre— requests: ‘The course is organised on the assumption that the students have knowledge in Mathematics, Content: ‘Combinatorial Analysis; Probability; Stochastic event and probability of the event; Formula of total probability; Binomial distribution of the probabilities; Random variables; Statisties definition, task of the statistics and some elementary measures of central tendency; Measures of spread; Normal distribution; Test of hypotheses. Outcome: Upon completion of the course the students are expected to be able to deal with statistical problems related to pharmaceutical practice Student load: Hours: Lectures 15 Preparation for lectures 15 Practicals 30 Preparation for practicals 15 Subtotal B Evaluation 30 Total 105 hoursCourse responsible: Prof. Borko Iievski, Faculty of natural sciences and mathematics 4Physical Chemistry Practical Information Code FFIH21 Statu Compulsory ‘Time schedul 2™ semester ‘Teaching methods: Lectures, practicals Dimension of course: 6.5 ECTS-points Number of hours: 30 lectures of 45 minutes and 45 practicals of 45 minutes Frequency: Once a year. Evaluation: Continuing: 50 points Final: 50 points ‘A student can pass the subject without a final exam if he/she collects at least 71 points throughout the semester with the following mark scale: 71-76 points ~ 6 77-82 points -7 83-88 points ~ 8 89-94 points ~9 95-100 pints ~ 10 ‘Teaching material: © Martin A. : Physical Pharmacy, Williams& Wilkins, 1993 © Minceva-Sukarova B.: Fizicka hemija, PMF, 1993 Purpose: ‘The objective of the course is to give the students knowledge about the main principles of physical chemistry in thermodynamics (phase equilibria, solutions, electrolyte solutions, electrochemistry) and reaction kinetics; Application of physico-chemical principles on interface- and colloid- chemistry, durability problems, phase equilibria and structural aspects in systems of pharmaceutical interest together with macromolecular aspects of relevance to pharmacy and biology. Theoretical foundation for the laboratory course. Pre~ requests: The teaching is organized on the assumption that the students have a knowledge corresponding to the content of the courses Mathematics and Biophysics. Content: Main principles of physical chemistry in thermodynamies (phase equilibria, solutions, electrolyte solutions, electrochemistry) and reaction kinetics. Application of physico-chemical principles on interface- and colloid-chemistry, durability problems, phase equilibria and structural aspects in systems of pharmaceutical interest together with macromolecular aspects of relevance to pharmacy and biology. Theoretical foundation for the laboratory course. Outcome: Upon completion of the course the students are expected to: © Demonstrate knowledge of the principles in physical chemistry* Discuss and explain the application of physico-chemical principles in systems of pharmaceutical interest, * Have practical knowledge of the experimental methods covered by the course Student load: Hours: Lectures 30 Preparation for lectures 30 Practicals 45 Preparation for practicals 20 Subtotal 125 Evaluation 70 Total 195 Course responsible: Prof. Zoran Kavrakovski, zoka@ff.ukim.edumk Insitute of Applied Chemsitry and Pharmaceutical analyses, Faculty of PharmacyAnalytical Chemistry Practical Information Code FFIH22 Status: Compulsory Time schedule: 2" semester ‘Teaching methods: Lectures, tutorials, group work, projects, practicals Dimension of course: 8.0CP Number of hours 30 lectures of 45 min, 15 tutorials of 45 minutes, 45 practicals, 15 group work, 1 project Frequency: ‘Once a year. Evaluation: ‘Continuing: 50 points Final: 50 points ‘A student can pass the subject without a final exam if he’she collects at least 71 points throughout the semester with the following mark scale: 71-76 points ~ 6 77-82 points —7 83-88 points ~ 8 89-94 points —9 95-100 pints ~ 10 Teaching materi Skoog D., West D., Holler F., Fundamentals of Analytical Chemistry, 7 Edition Harcourt Brace College Publishers, Purpose: To provide the student knowledge on the theoretical fundamentals of qualitative and quantitative analyses and the influence of the ‘experimental conditions on the chemical reaction and analytical results Pre— requests: ‘The teaching is organized on the assumption that the students have a knowledge corresponding to the content of the course General and Inorganic Chemistry. Content: The course is a base for the future courses and deals with the main principles of analytical chemistry; principles and application of the classical quantitative methods; usage of chemical reaction schemes, calculations of concentrations and chemical equilibrium. ‘The course comprises: «The scope and function of analytical chemistry: chemical reactions in solution; acid-base equilibrium; complexation equilibrium; solvent extraction; redox equilibrium; colour and precipitation reactions © Qualitative inorganic analysis: procedures for detection of ions in solution; sensitivity and detection limit 7© Quantitative analysis: analytical problems and their solution, sampling and sample pre- ‘teatment, the assessment of analytical data, gravimetry, titrimetry (acid-base, redox, complexometric and precipitation titrations) * Introduction to electroanalytical methods: potentiometry, potentiometric titrations, ion selective electrodes; conduncometric titrations Outcome: ‘The aim of the course is that the student after passing the course: * has knowledge of the influence of equilibrium on chemical reactions * has knowledge of the classical analytical methods described * can explain the principles of the methods, their application area and potential sources of error * is able to use chemical reaction schemes and make the calculations needed in the application of the methods, Student load: Hours: Lectures 30 Preparation for lectures 30 Tutorials 15 Preparation for tutorials 15 Practicals 45 Preparation for practicals 25 Group work 15 Project, 3 Subtotal 180 Evaluation 60 Total 240 Course responsible: Prof. Suzana Trajkovic-Jolevska, suzana jolevska@ffukim.edu.mk Insitute of Applied Chemsitry and Pharmaceutical analyses, Faculty of Pharmacy 18