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19.1 Multiple-Choice Questions: Chapter 19 Amino Acids and Proteins
19.1 Multiple-Choice Questions: Chapter 19 Amino Acids and Proteins
2) Collagen, a protein found in tendons and cartilage, would be classified as a ________ protein.
A) catalytic
B) structural
C) transport
D) storage
E) hormone
Answer: B
Objective: 19.1
Global Outcomes: GO2
4) Sucrase, the protein that facilitates the hydrolysis of sucrose, would be classified as a ________ protein.
A) transport
B) hormonal
C) catalytic
D) structural
E) contractile
Answer: C
Objective: 19.1
Global Outcomes: GO2
1
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5) The structural formulas of amino acids are the same EXCEPT for the
A) carboxyl group.
B) alpha carbon.
C) amino group.
D) side (R) group.
E) hydrogen bonding.
Answer: D
Objective: 19.1
Global Outcomes: GO2
- C HCH3
|
CH3
A) polar.
B) hydrophobic.
C) hydrophilic.
D) acidic.
E) basic.
Answer: B
Objective: 19.1
Global Outcomes: GO2
7) Which of the following would be most likely to be deficient in at least one essential amino acid?
A) eggs
B) milk
C) beans
D) steak
E) ham
Answer: C
Objective: 19.1
Global Outcomes: GO7
8) Amino acids that are not synthesized in the body and must be obtained from the diet are called
A) essential.
B) polar.
C) nonpolar.
D) complete.
E) incomplete.
Answer: A
Objective: 19.1
Global Outcomes: GO7
2
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9) Methionine is an amino acid that contains
A) a sulfur atom.
B) a chlorine atom.
C) a sodium atom.
D) a phenyl ring.
E) a heterocyclic ring.
Answer: A
Objective: 19.1
Global Outcomes: GO2
10) A completely vegetarian diet will contain all the essential amino acids if it includes
A) wheat and rice.
B) rice and beans.
C) almonds and walnuts.
D) corn and beans.
E) wheat and corn.
Answer: B
Objective: 19.1
Global Outcomes: GO7
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14) At a pH > 9, the zwitterion of glycine (pI=6.0) will have
A) a net positive charge.
B) a net negative charge.
C) an overall charge of zero.
D) low solubility in water.
E) a negative charge on the nitrogen.
Answer: B
Objective: 19.2
Global Outcomes: GO2
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16) What is the structural formula of glutamic acid (pI = 3.2) at pH = 1?
A)
B)
C)
D)
E)
Answer: A
Objective: 19.2
Global Outcomes: GO2
17) Consider a mixture of the amino acids lysine (pI = 9.7), tyrosine (pI = 5.7), and glutamic acid (pI = 3.2)
at a pH 5.7 that is subjected to an electric current. ________ will migrate towards the positive electrode(+).
A) Lysine
B) Tyrosine
C) Glutamic acid
D) All of the amino acids
Answer: C
Objective: 19.2
Global Outcomes: GO2
5
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18) Consider a mixture of the amino acids lysine (pI = 9.7), tyrosine (pI = 5.7), and glutamic acid (pI = 3.2)
at a pH 5.7 that is subjected to an electric current. ________ will remain stationary.
A) Lysine
B) Tyrosine
C) Glutamic acid
D) All of the amino acids
Answer: B
Objective: 19.2
Global Outcomes: GO2
20) The R group for serine is - CH2OH. As a zwitterion, serine has the structural formula
A) CH2OH
|
NH2 C HCOOH
B) CH2OH
|
NH2 C HCOO-
C) CH2O-
+ |
N H3 C HCOOH
D) CH2OH
+ |
N H3 C HCOOH
E) CH2OH
|
H3 C HCOO-
Answer: E
Objective: 19.2
Global Outcomes: GO2
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21) Which of the following functional groups of an amino acid would be in the ionized state at high pH?
A) O
-COH
B) -CH2OH
C) -CH3
D) O
-CNH2
E)
Answer: A
Objective: 19.2
Global Outcomes: GO2
7
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22) Which of the following is the correct structure for Ser-Ala-Asp? The appropriate side chains look like
this.
O
A) OH COOH
| |
CH3 O CH2 O CH2 O
| | |
H3 N+ C H - C - NH - C H - C - NH - C H - C O-
B) COOH OH
| |
CH2 O CH3 O CH2 O
| | |
H3 N+ C H - C - NH - C H - C - NH - C H - C O-
C) OH COOH
| |
CH2 O CH2 O CH3 O
| | |
H3 N C H - C - NH - C H - C - NH - C H - C O-
+
D) COOH OH
| |
CH2 O CH2 O CH3 O
| | |
H3 N C H - C - NH - C H - C - NH - C H - C O-
+
E) OH COO-
| |
CH2 O CH3 O CH2 O
| | |
H3 N+ C H - C - NH - C H - C - NH - C H - C O-
Answer: E
Objective: 19.3
Global Outcomes: GO2
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23) The peptide bonds that combine amino acids in a protein are
A) ester bonds.
B) ether bonds.
C) amide bonds.
D) glycosidic bonds.
E) sulfide bonds.
Answer: C
Objective: 19.3
Global Outcomes: GO2
26) Which of the following shows all of the tripeptides that can be formed from one molecule each of
glycine (Gly), valine (Val), and leucine (Leu)?
A) Gly-Val-Leu, Gly-Leu-Val, Val-Leu-Gly, Val-Gly-Leu, Leu-Gly-Val, Leu-Val-Gly
B) Gly-Val-Leu, Gly-Leu-Val, Leu-Gly-Val
C) Val-Gly-Leu, Gly-Val-Leu, Gly-Leu-Val, Leu-Gly-Val
D) Val-Gly-Leu, Gly-Leu-Val
E) Gly-Val-Leu
Answer: A
Objective: 19.3
Global Outcomes: GO2
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27) Which of the following shows all of the tripeptides that can be formed from one molecule each of
lysine (Lys), threonine (Thr), and histidine (His)?
A) Lys-Thr-His
B) Lys-Thr-His, Lys-His-Thr, His-Thr-Lys, His-Lys-Thr, Thr-Lys-His, Thr-His-Lys
C) Lys-Thr-His, Lys-His-Thr, His-Lys-Thr, Thr-His-Lys
D) Lys-Thr-His, Lys-His-Thr, His-Lys-Thr
E) Lys-Thr-His, Lys-His-Thr
Answer: B
Objective: 19.3
Global Outcomes: GO2
29) A chain made of more than 50 amino acids is usually referred to as a(n)
A) peptide.
B) protein.
C) enzyme.
D) globulin.
E) hormone.
Answer: B
Objective: 19.4
Global Outcomes: GO2
10
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31) The α helix of the secondary structure of a protein is held together by ________ between two widely
separated parts of a protein chain.
A) hydrogen bonds
B) disulfide bridges
C) salt bridges
D) hydrophilic interactions
E) hydrophobic interactions
Answer: A
Objective: 19.4
Global Outcomes: GO2
32) In the β-pleated sheet secondary structure of a protein, two or more amino acid sequences in separate
parts of the protein are held together
A) in a coil, by hydrogen bonding.
B) in random order, due to hydrophobic interactions.
C) in a triple helix.
D) in a double helix.
E) in a zig-zag conformation, by hydrogen bonding.
Answer: E
Objective: 19.4
Global Outcomes: GO2
11
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35) The interactions that are important in the secondary structure of a protein are
A) hydrogen bonds.
B) hydrophobic interactions.
C) disulfide bonds.
D) salt bridges.
E) peptide bonds.
Answer: A
Objective: 19.4
Global Outcomes: GO2
38) In insulin, two peptide chains are held together in a single unit by
A) disulfide bridges.
B) hydrogen bonds.
C) salt bridges.
D) a prosthetic group.
E) a β-pleated sheet.
Answer: A
Objective: 19.4
Global Outcomes: GO2
12
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40) The heme in hemoglobin is a(n)
A) protein chain.
B) small molecule within a protein.
C) helix area in the hemoglobin molecule.
D) pleated sheet area in the hemoglobin molecule.
E) oxygen molecule within the hemoglobin molecule.
Answer: B
Objective: 19.5
Global Outcomes: GO2
42) Hemoglobin has a total of ________ protein chains in its quaternary structure.
A) one
B) two
C) three
D) four
E) five
Answer: D
Objective: 19.5
Global Outcomes: GO2
43) The fibrous protein responsible for the structure of hair and wool is
A) keratin.
B) collagen.
C) endorphin.
D) myosin.
E) casein.
Answer: A
Objective: 19.5
Global Outcomes: GO2
13
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44) Which R group would most likely be found in a hydrophobic area of the tertiary structure of a
globular protein?
A) -CH2OH
B) -CH2COO-
C)
D) -CH2CH2CH2CH2 H3
E) O
-CH2 C NH2
Answer: C
Objective: 19.5
Global Outcomes: GO2
45) What type of interaction would you expect between the following R groups in the tertiary structure of
a protein?
A) disulfide bonds
B) salt bridges
C) hydrogen bonds
D) hydrophobic interactions
E) peptide bonds
Answer: B
Objective: 19.5
Global Outcomes: GO2
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47) What kinds of interactions are NOT part of tertiary protein structure?
A) peptide bonds
B) disulfide bonds
C) hydrophilic interactions
D) salt bridges
E) hydrophobic interactions
Answer: A
Objective: 19.5
Global Outcomes: GO2
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52) Denaturation of a protein
A) changes the primary structure of a protein.
B) disrupts the secondary, tertiary, or quaternary structure of a protein.
C) is always irreversible.
D) hydrolyzes peptide bonds.
E) can only occur in a protein with quaternary structure.
Answer: B
Objective: 19.6
Global Outcomes: GO2
16
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19.2 Bimodal Questions
2) What amino acids have polar R groups that are attracted to water?
A) hydrophilic
B) hydrophobic
C) nonpolar
D) aromatic
E) hydrocarbon
Answer: A
Objective: 19.1
Global Outcomes: GO2
3) At what pH would you expect valine, an amino acid with a neutral R group, to be in the zwitterionic
form?
A) 1
B) 4
C) 6
D) 10
E) 14
Answer: C
Objective: 19.2
Global Outcomes: GO2
17
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4) Consider the R groups of the following amino acids:
cysteine: -CH2SH; alanine: -CH3; serine: -CH2OH
The name for the dipeptide shown below is ________.
CH3 O CH2OH
| |
NH2 C H - C - NH C HCOOH
A) alanyl-cysteine
B) alanyl-serine
C) seryl-alanine
D) seryl-cysteine
E) serine-alanine
Answer: B
Objective: 19.3
Global Outcomes: GO2
5) The peptide hormone that regulates uterine contractions during labor is ________.
A) oxytocin
B) vasopressin
C) myoglobin
D) an endorphin
E) an enkephalin
Answer: A
Objective: 19.4
Global Outcomes: GO2
6) In an enzyme, the polypeptide chain folds into a compact shape known as the ________ structure.
A) pleated
B) primary
C) secondary
D) tertiary
E) quaternary
Answer: D
Objective: 19.5
Global Outcomes: GO2
7) When two protein chains combine to form an active protein, the structural level is ________.
A) pleated
B) primary
C) secondary
D) tertiary
E) quaternary
Answer: E
Objective: 19.5
Global Outcomes: GO2
18
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8) Hydrophobic interactions help to stabilize the ________ structure(s) of a protein.
A) primary
B) secondary
C) secondary and tertiary
D) tertiary and quaternary
E) secondary and quaternary
Answer: D
Objective: 19.5
Global Outcomes: GO2
9) What process occurs when heat, acids, bases, and heavy metal ions cause a loss of biological function of
a protein?
A) denaturation
B) saponification
C) hydrogenation
D) amidation
E) esterification
Answer: A
Objective: 19.6
Global Outcomes: GO2
10) In digestion, proteins are broken down into amino acids by a(n) ________ reaction.
A) saponification
B) reduction
C) hydrolysis
D) oxidation
E) denaturation
Answer: C
Objective: 19.6
Global Outcomes: GO2
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4) Amino acids that are not synthesized in the body but must be ingested with the diet are called
________ amino acids.
Answer: essential
Objective: 19.1
Global Outcomes: GO2
6) The isoelectric point for any amino acid is the pH at which the amino acid has a net charge of ________.
Answer: zero
Objective: 19.2
Global Outcomes: GO2
7) Electrophoresis is a laboratory technique for separating amino acids using their different ________.
Answer: isoelectric points
Objective: 19.2
Global Outcomes: GO2
Objective: 19.2
Global Outcomes: GO2
Answer:
Objective: 19.3
Global Outcomes: GO2
20
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19.4 True/False
4) The dipeptide abbreviated as Gly-Lys is the same as the dipeptide abbreviated as Lys-Gly.
Answer: FALSE
Objective: 19.3
Global Outcomes: GO2
5) Sickle-cell anemia is caused by a change in the primary structure of a subunit of the hemoglobin
protein.
Answer: TRUE
Objective: 19.4
Global Outcomes: GO2
9) Upon hydrolysis the dipeptide abbreviated as Gly-Lys will yield the same products as the dipeptide
abbreviated as Lys-Gly.
Answer: TRUE
Objective: 19.6
Global Outcomes: GO2
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10) Lead ions disrupt hydrophobic interactions.
Answer: FALSE
Objective: 19.6
Global Outcomes: GO2
A) quaternary
B) tertiary
C) secondary structure
D) primary structure
1) The protein folds into a compact structure stabilized by interactions between R groups.
Objective: 19.4, 19.5
Global Outcomes: GO2
3) pleated sheet
Objective: 19.4, 19.5
Global Outcomes: GO2
5) the structural level achieved when hydrogen bonds form between the carboxyl group of one amino
acid and the amino group of a different amino acid
Objective: 19.4, 19.5
Global Outcomes: GO2
Answers: 1) B 2) A 3) C 4) D 5) C
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Classify each protein by function.
A) contractile
B) structural
C) catalytic
D) protection
E) transport
9) antibodies
Objective: 19.1
Global Outcomes: GO2
Answers: 6) C 7) E 8) B 9) D 10) A
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Would an amino acid with the given R group be most likely to be found in the hydrophobic or hydrophilic region of
a protein?
A) both
B) hydrophilic
C) hydrophobic
12) - CH - CH3
|
OH
Objective: 19.5
Global Outcomes: GO2
13) - CH3
Objective: 19.5
Global Outcomes: GO2
14) -CH2CH2SCH3
Objective: 19.5
Global Outcomes: GO2
15) O
-CH2 - C - NH2
Objective: 19.5
Global Outcomes: GO2
16)
Objective: 19.5
Global Outcomes: GO2
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17)
Objective: 19.5
Global Outcomes: GO2
19)
Objective: 19.5
Global Outcomes: GO2
Answers: 11) C 12) B 13) C 14) C 15) B 16) B 17) B 18) C 19) C
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