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• Personal history of breast cancer: A history of cancer in one breast increases the
likelihood of a second primary cancer in the contralateral breast.
• The family history of breast cancer and genetic risk factors: First-degree relatives of
patients with breast cancer have a 2-fold to 3-fold excess risk for developing the
disease. Five percent to 10% of all breast cancer cases are due to genetic factors,
but they may account for 25% of cases in women younger than 30
years. BRCA1 and BRCA2 are the 2 most important genes responsible for increased
breast cancer susceptibility.