Mechanism Of Action:

Monobenzone is a depigmenting agent whose mechanism of action is not fully understood.

Monobenzone, applied topically to the skin, is used as a depigmenting agent inhibiting melanin
produced by polymerization of oxidation products of tyrosine and dihydroxyphenyl compounds.
Monobenzone works by permanently removing color from normal skin located around skin with
vitiligo.

Monobenzone may cause destruction of melanocytes and permanent depigmentation. This effect is
erratic and may take one to four months to occur while existing melanin is lost with normal
sloughing of the stratum corneum. Hyperpigmented skin appears to fade more rapidly than does
normal skin, and exposure to sunlight reduces the depigmenting effect of the drug.

Administration:

• Apply a thin layer of Albaquin to the normal colored skin area which requires
depigmentation usually two to three times daily or as directed by physician. There is no
recommended dose for children under 12 years of age except under the advice and
supervision of a physician.
• It may take up to 4 months before the full benefit of this drug takes effect. Once the desired
skin color is achieved, this medication is applied only as needed to maintain the new skin
color (usually 2 times a week). Use Albaquin cream regularly to get the most benefit from it.
• Inform the doctor if your condition persists or worsens after 4 months.

Side Effects:

Mild burning, irritation, redness, cracking, or peeling of the treated skin may occur. If any of these
effects worsen, tell your doctor. Skin that is not treated with Monobenzone may also become
discolored or irregular in appearance. Sometimes these effects may be permanent.

Many people using this medication do not have serious side effects. A very serious allergic reaction
to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a
serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat),
severe dizziness, trouble breathing.

Precaution:

• This medication is for use on the skin only. Albaquin cream should be applied with a patch
test for 48 h to detect hypersensitivity.
• Avoid application of Albaquin to the eyelids and areas close to the eye.
• Avoid getting this product in your eyes or on the inside of your nose or mouth. If the cream
is accidentally applied in these areas, flush with plenty of water.
• After using this medication, the skin will be permanently affected and sensitive to sunlight.
Avoid prolonged exposure to sunlight. Always use a sunscreen of SPF 15 or greater, and
wear protective clothing when outdoors.
Warning:

• Monobenzone is a potent depigmenting agent, neither a skin fairness cream nor mild
cosmetic bleach. Do not use unless prescribed by your doctor or without strict supervision of
a Physician.
• Do not use this drug to treat other skin discoloration problems ("sun spots," "age spots,"
freckles, skin discoloration caused by hormone medicine, perfumes, pregnancy, or skin
trauma).
• Keep this out of reach of children.