kadar

waktu AUC SO Ln SO AUC IV Ln IV

oral iv
0 0 1.8142 0.6875 Err:502 1.7811 0.5956
0.5 2.75 5.31 2.2475 1.0116 2.4825 1.6696
1 6.24 4.62 3.6850 1.8310 2.1600 1.5304
1.5 8.5 4.02 4.5775 2.1401 1.8800 1.3913
2 9.81 3.5 8.6200 2.2834 3.0750 1.2528
3 7.43 2.65 6.5150 2.0055 2.3300 0.9746
4 5.6 2.01 8.7900 1.7228 3.1700 0.6981
6 3.19 1.16 5.1000 1.1600 1.8200 0.1484
8 1.91 0.66 -7.6400 0.6471 -2.6400 -0.4155

AUC (0-8) 32.5825 16.0586

Slope 3 titik terakhir (dalam bentuk ln)
AUC (8-~) =C (t-8)/b

AUC total 32.58 16.06

F absolut = AUC SO/AUC IV*D (IV)/D (SO)*100%

RUMUS TRAPEZOID (LUAS TRAPESIUM) Luas = 1/2 x Ruas Rusuk Sejajar x Tinggi

ORAL 500 mg
Iv 200 mg
 Oral
12

10

Axis Title
6 Column B

0
0 1 2 3 4 5 6 7 8 9
Axis Title

Grafik ln kadar oral

2.0000
1.8000
1.6000 f(x) = − 0.268915838920641 x + 2.79012528572265
R² = 0.999285236299989
1.4000
1.2000
1.0000
0.8000
0.6000
0.4000
0.2000
0.0000
3.5 4 4.5 5 5.5 6 6.5 7 7.5 8 8.5
 IV
6

4
Column B
3

0
0 1 2 3 4 5 6 7 8 9

LN kadar IV
0.8000

0.6000 f(x) = − 0.278412541508162 x + 1.81415501012484

R² = 0.999945649758282

0.4000

0.2000

0.0000
3.5 4 4.5 5 5.5 6 6.5 7 7.5 8 8.5
-0.2000

-0.4000

7.5 8 8.5 -0.6000

NO. SAMPEL AUC total kapsul A AUC Total kapsul STD F
1 15 15.8 94.9367
2 22 19 115.7895
3 18 19.3 93.2642
4 18 18.4 97.8261
5 16 17.2 93.0233
6 17 16.5 103.0303
7 18 17.9 100.5587
8 17 17.5 97.1429
Rata-rata F 99.4464
Standar deviasi (SD) 7.4539
Standar deviasi rataan (Sḟ) / (RSD) / (SDR) 2.6353
tα (dk=7) t0.1 (dk=7) 90% 95% 98%
1.8690 2.308 2.856
CI (+) 104.3718
CI (-) 94.5211
80<CI>125