Emeritus Professor of Pee
Psychodynamic
Treatment of
Depression
Fredric N. Busch, M.D.
1 Associnte Professor of Poychiatry
‘Weill Medical College of Cornell University
Faculty, Columbia Univesity Genter for
Paychoanalytic Training and Research
‘New York, New York
Marie Rudden, MLD.
al Assistant Professor of Poy
Berkshire Psychoanalyt
Faculty, New York Poychoanalytic Lust
‘New York, New York
Theodore Shapiro, MD.
Ws
fedical College of C
ing and Supervising Analyst,
i Tostione
Tr
New York Peychon
NewYork, New Yorkrr Psychodynamic treatment of Wepression
ele MB ans Dt, Klein DN: Semana ofthe DSNLIV mood doers eld
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Phy oop 6):1319, 1989
Chapter 2
Development of a
Psychodynamic Model of
Depression
Ticorists have developed variety of modesto explain why certain inde
viduals develop depresive disorders and to ad in the development of «
treatment plan for them. Vulneabihy to depresion has bees explained
‘arious it terms of Biochemical, interpersonal, and comnitvebehaviorst
todel: Other theorxs have sed a ryehodyainic model explain che
Comps et of Felings and behaviors dha make up depressive disorders
‘Tha book focuses oa the pryeodynamiec approach asa comprehosive
metus uvderstaningand testing depresioe thats complementary 0
the other models and approsches- tn thin chapter we provide brief sum.
inary of paychoonalyc ineotes of depreaion, describe sues of paycho-
Toga conthibutions tothe dixorder, and present a psychodynamic fr
‘maiaton tat canbe employed in guiing treatment.
Paychoanalys have developed succeatve, overlapping models to ex
pain the ecology and peristence of depressive ymdromes These models
hha considered the indivcual's iological and temperamental vilner
Vales, the quai ofthe persons east tachment relationships, and
significant chldnood experiences that may have been accompanied by
frastation, shame, loss, elplsinss, loneliness, gut. The impact of
suck experiences nd elings doing formative developmental sages on
individ’ perceptions of themselves and others is seen a creating
amie sucepbes to a range of depressive syudromes tse life
Jnckling narelsiie dna, comBlcted ange, excessively high ex
pectators of self and other, ad maladaptive defense mechanisms
13ro bestiussate the various psychodynamic models of depression, we
describe tir application ta specifi cae
case Bample
Ms Gasan nerve yeaolddorced acouncnt who presented
Tor reument wa isn af cera er of ety spe nd
reat epanter of sperinped sje depression. Dung depreine
‘Sines, er pms nade er ener and moun mpd
creeettannnncrened appeste wi wegen 20d mola et
‘it nsoanin Ms Cove here wore apd not deserving of
Teron umes pepe tbe sae ne hat he ws for about he
(eer Statcntion She was Requerty opel about changing her str
tig and wouter have cial oaghtsof pl verde She
pa aden nett se arava screwing ings up" Dui
Ue oun ofwentmens devel bl is Cece ses of mek
{aon wit moderate pact om ber deprive ples
Tir seid a tecaror tendency fel rejected others expe
siege ies ast aingor purposes Ni Cote
cena what ie pees o be unan eient epecil by pe
Sine ty Use on whom he depend. These feeings aerate ith
le othonelfa obese ie and ata
Tbcame apparent during the ail erent Mi Cb be i
slit fllowed a prs ae She entered mo relanshis 8
nie snl hang ion, sewing eel ara person oie ave
seerught appro! lm a power eang other Over ne owes
Meets tec unapplecned ined oroveooked Mi Could
reine net and doapgoiatt tat ne other peor wes ot bese
Ign scot respon atoning aretater Feng iinshed
MEtjecer se woul earring her ppoinunens outa at
Ther penn would eect hetero contr her suspicion tat
{Benes ened as inadequte and unde
inisconee Mo woul cna pone aggresie manne Fort
sa ins nuld come ne to metingrat er job or become wie
Pau in her aoa Ofer ste nav unnvare othe wy bind
SEESRMiuror othe potential impact ersllen stance Tn eponse
CEERI eta? te Indiv wi om te nas dsapeined
son en wae i ie Coo fe igiea. Se would oe here
“Sunjy tem ond ws fr someone to rec hr and igh th or
SEE had ocsonet: Over ine, however se woul become ate
Iie sere an slr he longer ecreaing of eran
(Bipot sceur ler rage woul becone een alee
[canny of cored Cc, where she a bea &
secy uae members aien taking oa many ofthe del volumes
Tie pce aed he chee lade a orig arg men
hose pece regard soothe her longatanding Loy selesteem Hone
ToC ees fee che leaders ere eponsve fo
er prottems wih her hotbnd om whom she was ater doer
‘Ted penance her un vera abuse and cca, Whe
the yo of them me ith he ede she fk tat hey were siding wih
Fim andgronng her concern She came ary ae ot eve he
{Iscomen tote church lenders. However she appeated resend
tecame doteltnbe hes Thechurch aces, nes ated
sinh her betevion easly encousged Bort feave the paish When
Tie Cenaty sees he concen se id to ia seat terete
‘Me Cappeie her cae higher church lender, convince tht he
woud years poosnces Whe the dt pt oc she was ete)
Uapporeed and plunged ices depeese sate She tegen fo Dame
Senelir tes pres and il her vores nd inasegsny were
the wee ofher selection by the hare
“Aine senso event oeuired st Ne-C50b where she asshoeked
soseceneanefane work evi rect her employersdisaustcon
(Sats as efance an sullen, otha Alou she nally at
‘Noein resew's noprviy toners iporanee oferta are
stern en mie ender shri oe
Ma C dened proving up nan soghere of meetin whic she
fener press perc ocinreedio Beran abe bso ings
Her muther nar pel an aggressive. la otion to interateny
{erent Me abou her ful an aperfectons she woul eg
[Enpengae inaggrashe rslaton eters te communi, Ths
[edo censan.dsrpton fe mother ladon andan tolted
‘Sinenee forthe fay Her ner sph more ind Re wa ee
Sy pevced ws unmile sno sthr sorted nor fhe
iuhunetde thei the pes deal ih er ota Ms Cn
‘ied ofconttondng bee mothe bere he reported Dat hen she ha
Gone one paws hee other woul pt speds toes ey, ing
er tekng hep and sey
Me sone te tat inpotant te hat she nob ke
het mote an she made every effort ott do so This seed be
ne mon fr ber yon Belpal behavior on sialy nec
incon she weld ew any auemp ac sears it avery ctl
Ton asst sc fits er ter aggresive atc 09
‘rcs Ca el ey guy nen she wage se fared ping
‘they apurtnabe nd wen her mther co. Ulu Ms woul et
inc hemet'or being ike he oer wen sbe beeame cnrgedt other,
‘Ser wg se exjeewed er anity para in pave manne,
Psychodynamic Models of Depression
Ms. depresion can be explained by arin ofpehodymamic models,
‘putforth by ferent pachoanalyc theorists (Table2-1), Below, we apply
{Each mode! to the cave oF Ms. We then use chese theories to sil ase
‘St pnyetodyamie factors ental to the wadesstanding and reatment of
‘depression.we sychoaynamee treatment er vepression
ale TA Pophodjramie model oF depression
‘rata
Freud
Pripecing Bers
Dyamic
rdipoing actors
Drone
ving
redoing fain
Dream
Jacaboon
redoing fore
Proanie
Proame
Sander ano
Pretning coe
Dream
“Taunt ety expres temperment
roensiytvard speech becomes
Aicsed a odes
Ange projected onto oters, ho are then
hpetenced at stati contest eof
Rewinmdegonte an ober ofsorm and hor
eres In of sion fr wom he patient
‘apeiencer ines ambiraers tela
Tenicton whe ort oer, anger toward he
‘ter becomes dete ows there
‘Nace vlneabn nee for oten bates
veltexees
‘Ga ape ofthe ater internalized in
‘aperego what atace "ad sepecsteoalied ia
eyaraton ofa cis dependent esd
Discrepancy between the eo ea (hat one woud
The tobe} andthe eo the so
Atak of parental acepance aod emotional
indeeanding abaence tard eters
Augrenion toward deppekaing pares becomes
teleireced wo protec ibe loved wher
Intestine ng parental sts ead 0
pene geno
Distance of a eidhood celaonship with
lptenne an rseaton with ds selaonsip
tects reactive corer send fel
severe speres™
erento tia lu of 3 elton aus
Tdnging ir tedealized tte feng ove ane an
(pene of lrcepleton lading to depresion
Table EA. Pychadyramie modes of depression conte)
Fredieing factors Heterogeneous factor neu thot mentioned
‘omer eo
manic {canton or daempomerment sexpert for
egrnie compenie, eal wate a8 ges
“Efren sazeion in vxpone 0 Ba becomee
scbadoecet
Fea etre ‘una wea nse ihey ie
forlowscteseen
Ponty
Pepa iron on aap chet te om
Dynan Internal mode of ten as unloable nd
Trades ang ote 36 responsive ad
pine gtd by oe aera
Early Psychoanalytic Models of Depression:
Disappointment, Loss, and Anger
“The Gist payehoanalytic writezs to develop the concept that depresion
rginter om narcisiste valnerabili, developmental traumas, and
Coulied anger inched Abrabam (1011, 1924), Freud (1917) and Rado
(192),
‘Abrahars (191), 1924) provided an initia) analytic framework fr wx
dernanding depression when he Gescribed the syndrome as resulting
hom host tonard others tat becomes self directed, Depresed patents
tei whom fe wosked demonsratea propensity, based on temperment
srethy experiences toward hatred ad ristrat of others (Abraham
{oL0,Feeing unable ove the prople with whom hey are connected bt
{nghtened an guily about thelr age, uch patents repres thes hos:
ty andl peoject it external, They begin to fee ated and thea connect
tbetrsene of being disiked wih varios phological or piysica dein
‘des "People hate me because ofthese defees.”
Abraham's description oh cent woul be consistent with pects oF
Mes inerpemonal dilemmas and beequent depresions. Ms. C was
troubled ty penitent anger toward other of wich she was on minis
lezen escalated. She wove shen project this anger onto oderv and
tee the at hating her Ms. C would then eonelude tat she mest have 8etet dat woul Hea oer to eat her this way In ation, her pereep-
lon afte world asa hateful place wae during and demoralizing
"Sopplementng Abraliam’ nial oervaons on the dynais ix peo-
ple with depression, Freus (1917) dearbe an additional model or some
Bose: On the basis of his observations of simliaries between bereave
‘hent andthe depresed state, Feta hypothesized hatte fos of an i
‘Pont pero i the individual ie, ether in ral or in Faas, can
Tigger he onset of depression, As incom mourning, however. ade
presion fs smulaed when the person who i ost has been the abject of
Ftenely ambivalent feelings om the part of the patent The depresed
tua denies with or takes on as part of nel or herselt, one or
other ofthe ln person's characterises, to maintain a fecling of con
rection wth that person an to misigate aginst the sense of fos ar be
envement-flowerer,Becate the last person was vewed with ambivi
tence, the anger orignaly directed toward that person now becomes
lected toward the new atributes the paint has adopied. Axa est
the patent begins to experience intense selec and reproach, which
‘rental lal o depression,
Tn accord with Frew’ theory of entiation, when Ms, Cieatifed|
reef wih her mother's aggesive and hu behavoss omar’ oben,
the became extemely selFeriscal and fle worthless and unlowable. In
Ms. Cheats, however, te Tow that consected most immediately wis her
urrentdepresion was that of hee rapport wit che prewouly idealized
urchins nother ther Thi can bestbe understood by Abrahams
‘Hn to refine Freud's theory and make it consistent with his ear
Thodel. Abraham (1924) ee to view an episode of adult melancholia ax
Nemning rom a urrent diappoinunent in Ive wich viewed, usually
Tinconiioushy as repetition of an eary childhood trumade experience
‘Abraharn (1924) posted that the depremed padent had hada ever i
jry to a eaty healthy sense of narcissism (eater) byway of eit
‘hed nppointment in lave, tally tthe hands ofthe mother Such an
Ryuy could sem for example, fon losing view of the self as a parent
favorite or frm disappointments in gaining an allance wit the mother
pana the father (orice wera), Onset ofthe illess in advthood ig.
ured bys new disappointment, unleashing strong hostile feelings va
hove incivduals, pau and present who have darted the patient’ dese
far love. For MG, the church leaders she had rei on emosonall be
‘Sine the objees of considerable hosiisy once they dsappointed her
‘Tis she dcrmonsrated a teadiness to Become enraged at those indivi
“hwho lite her mother had diappointed or neglected her Int, com
runs by MC linked her anger at de leaders wth her mother. "people
‘ho preach ote thing and behave completely diferent
Like Freud, Abraham posite! chat an identification with he rejecting
petsne—past or present leads 0 pathologial and merciless attckon
the sele. Once Me. G experienced herself an having the same aggresive
impulses as her mother Had, she became irsiensely self-critical
Rado (1098) cinplifed the theme of injred narisism in depressed
patent, He observed that is patients wih depression had an intensely
Strong craving for others to utwess heir sefesteem, He noted dat ac
Companying iis intense ering fr nzcssisti graifcation wasan inte
Ceanceofdhappointmeatin the self or others. Ths, depresed patients
acted to rival ofeuses an to fires in expectation not onl with ir
[ppotstment and anger but ao tha sigoeane fal ntheir selbester,
‘They seemed wholly reliant om others to feel valued and value
iC resembles Rado's patients i this regard Her depresion con-
nected not ony tohersacneseand anger about the cris’ presume mor
“one unsesponsivenes bat also ro her perception that he effrs within
the church (aod a work) were overlooked or underestimated. This com
‘ete 0 the spiral of recsminstions—against the earch leaders and
Ther boss an also against here as being itadequate and without value,
‘Thus Ma Cattacked here not only for being angry lke her mother bit
hho forsceming wortlew to ors ad being unappreciated by them.
“Adding to the themte of ange thar becomes selFdirected, Rado for
thr deseribecaplit that ake place nthe perception of selfand otters,
iin the depressed patent begins wo sce the seo others a ether all
{ood oral bad Inthe proces of development of depression, the good
[Galiiesof she loved one ae internalized inthe patients sense of wom
ear ahe woul ie tobe (or te ego ideal), whereas the had qualities,
tin Freuds formulation, become incorporated into dhe perception of
the ego (ore). The self become the whipping by ofthe superego, oF
the comacience funeton, which pinahes the patient for flures to ve
Upto tie egoideal Thus Ms C internalized the selvighteoures of her
rrother i her superego and ego ideal, with the expectation that one
‘hould alaysbehave wi moralrecttade and kindnes, and atacked her
selfor being unable to meet these standard
Later Models far Depression: Problems With
Self-Esteem Regulation and Aggression
Biting (1958) followed Rado in hisemphasis on che depresied patient's
‘iteates wit feelings of nares njry but ditfered wih him ana
‘ihe aay in what he saw aster averemphasis on mates of the s-
perego and agro, Insead, Bibring viewed depresion aang px
unt om dius wih esteem regulation. Lowselfexeem, inthismodel, derives fom a significant gap between the patient's slew and
nat he orshe woul wish to be ofthe ego ideal deseribed i the previous
subsection
Tn Bibring’ sew, primal experience of helplessness was most signi
icant in contrbuting to the surcepebiay to depression, Hedplessness,
which can develop om persistent usration ofachilds dependent nee,
Teneo a sense of are and lew selesteem. Rather than anger toward
‘biersand subsequent gui fueling the depression, helplessness tggers
fettirected anger A predispossion toward depression is seen by Bib>
fing. then, as determined by a constiationa intolerance of rastation,
byte sewsity and extent ofstuation o helplessness and by ater dev
‘nee factors that might confirm de paints sense of elElsappoint
‘ment and faire
“Seen rom Brings pint afew Me. Cow selfesteem stems fom the
iserepaney between her sense of here 3 angry and hurtful ke her
nother and her ego ideal of being 2 very mora and caring person. She
Iayhave viewed thiinaceqvacy as he cause ofher father’s dsincinaion
Colelpherand of her mother’ perceived neglect A seve of heplessnes
Shout capturing their recognition stimulated significant anger tard
Fersef not only a 2 deflection of her rae and disappointment toad
erparenisbut alo onc ofa sense of fruraton and contempt card het
selffor her inabiy to capture cir love.
“cabo (1954, 1971, 19%) offeredan altematie approach to consid
ring selfeteem regulation within the depressed patent, According
Jocaaon, alack of parental acceptance and emotional understanding
Innes the child's seesteem, Leading to ambivalence, aggresive fe
Tras tomard the pores and gui This aggression is turned against the self
ha defensive stegy to protect he loved person and to prevent the self
ftom enacting hose impulses toward the external worl, Jacobson be
eve that further counteract the negative impact of parental sitedes,
the deprrned patient develops an excersvelyperfecionistic reactive eg
deal snd an encesvely strict superego The patient bases hinselfor her
fellfor any ais or behawors that resemble those despised and eared
fe the parent Loved ones are deaired s part ofthe sategy of protect.
tng them rom aggression and supporting the patent’ agile seiestes,
‘This idealiaion leads the depressed individual to expect ser fo do
more than they realisealy ca, leading to recurrent disappoints,
“Thus, the dependency on an overated other andthe presence of exces
sively high settexpectations lead to. a8 waste and diminished sense of
seleescem and o nasi vlnerabily.
“Applying Jacobson’ Cormuation to the case of Ms. C further clarifies
thetypesot interpersonal relationships chat contribute to er suscepabi-
Development ofa Psychodynamic Model of Depression 2
iy eward depresne episodes, Namely, she ideals oxhers to support
ber fragile selfesteem and mite fer anger. Tais idealization, howeven
Ineitabiy leads to disappointment i those on whom she depends. Her
angerin espa to this appointment wigges gui at ceminds he of
Der voladle mother, lowering her sefesteem. She fis co ve up to her
coverh pefectiicselfexpectaons and er share about this adds 0
ber depressive affens,
‘Stone (1986) highighted particularly the reactive aggression that de
‘elopsin a deeply urating early relationship beeen the person who
Inter develop depression and hie or her parent. The aggression becomes
texpresed in repeated, fled attempts to cource he paentto respond io
Tis or er ces, Asevere superego develops, fale bythe helpless ange.
Following Stones model a therapist night explore extensively wit
-Ms, Couancesin het historical rlsenship wid ber moder, compasion
acl bighighiag her efor to coerce ths seemingly unresponsive pa
tent ai then others int secogaizing and addressing her needs, Thsap
proach might help the pasent recognize her hostility and its impact on
thers aa find alternate anentes for expressing her dsappoiauens
‘Sunler and Joe (1955) researched the extensive case Fes fe Hamp-
steal Clinic to look for dyanmie treba thei ld patients sowing ee
idence of depressive eromes. These authors found tat the depresive
reaction seemed to actu most often when children felt that hey hae lost
tomsthing eset other aelesteea and fet helpless io undo defo
“ypiealy thie was the lows of an esportant loved on in reality or fama,
and especially of tate of well ing mpi nthe relationship with dat
[pein This state of welling tends to become idealized: The more itis
leotard longed fo, the greater wil be the depresv reaction in he
face of isunatainbii, Wocking wih ther model, one might empbasne
trih Ms Cte los afer sente of welkbeing that existe when she Felt
hpported bythe cleric and pleted wth her sense of accomplishment at
ror and focus on her depression ax repressing yearning to ren
at ste
Rather than focusing om os aa wgge for depresion, Brean (197,
4979) sow many of bie patients a8 imagining themselves to be decisively
Auemponered, or symbolically castrate, by otters 8a punishment for
‘competitive, esual, and aggressive wshes Thus, actual or fancasized sc
ees could be a tigger of depresion wa the need for punishment, and
depression cold be 3 means of diminihing a more elfecve, competi
tre stance. Aggression i mobiled aging he person Died for creat
ing this dserapoweriiens but becomes self-directed 35 he patent begins
tesdopt an ingratiating or propidatory stance tovard the Blamed but
feared pry2 Psychodynamic Treatment of Depression
Using Brenner's pespectiv, a therapist would atemp 1 discern for
hich bildhood wishes sexual compete, aggresive Ms. Cmay have
Felt hat she had been punished, causing her to experience herself an
Ihelpiexs powerless indnadual overiooked and noved by al Tn fc. thi
patients childhood concerns about compective feelings toward ber
Inother forher futher’ attention and her appatent fear of punishment
tye mother were seen by her therapist asgafcant inthe evolution of
hee guilty inibitons.
out (1971) wrote extensively abot pases’ problems with marci
icin an was patculry interested in ses of technique in engag
Ing and treating such patieats, According to Kohut, depresive affects
innarcissisically wlserable individuals ae related to chose feelings
‘emptiness in response to raumnatialy unempathic parenting, When
children's alfecve experience are no sensively mirrored by thets pr
‘ary earetakers. they ae lel feeling alone wth del experience and emo-
tionally emp and they struggle to 6 themselves by finding others to
Ideal and went ith, Techical tention 1 itoring these pies
feelings and to iasves of iealzation and devaluation inthe wansference
felatonsip wit the therapist are emphasized (Kohut 1971), Ms. C's
eaten, described in Chapter § COverview of Pachodymamic Pacho-
‘herapy for Depression") in this wohume, was enhanced by ber therapit’s
tention to ths patent’ hunger for recognition and empathy.
Attachment Theory
[Auachinent theory, a# developed by Bowiby (1968, 1980), dravs heal
fon am etholgical and adaptational perspective and has bad igican
intuence on piychosnatc models of pychopathology. Bowiy viewed.
tachment aya behavioral satem easel for survival, and disruptions
attachment. such alos ofa parent, ax crucial in che etiology of ans
lous and deprenive disorders Lows riggers series of responses Soy
protest anaiety, mourning, and ultimately, detachment. Disrupted atach-
fem due to tsecure al uneable relatonships with paren ort heir
ejecting and crital behavior, ted to the development of internal od
‘lsat the seifasunlovable and inadequate and of othersas unresponsive
Sind punitive The individ! becomes vulnerable to depression inthe set
ting ofater experiences oflom or adversity secing such losses as signs of
falure and expecting litle seppor fom others
“Athough Ms Gi no lea parent eaey ia Lf, her experience of ds
rupted stachment from cateal and emotionally unresponsive parents
‘leuy contributed to her view of herself as inadequate and helpes to
‘ange complex and adverse siatone The fos ofthe church incensed
Development ofa Psychodynamic Model of Depression 2%
fecings offre, helt age, and hopeless aboucher abi to have
succes atachiments to ther For eaimpe, Ms Ccheugheit was uses
{olookfora ev erch beeaue woul invariably lead to another faire:
Defense Mechanisms in Depression
Psychoanalytic theorists have considered the posbiity that certain de
fem (.e inzmnal or behavioral means of averting painfl feelings or
‘vestening uncosscous fantasies) ether may be specially mobilized
ty depres alec or may predispose indinidals othe development of
depressive syndromes (Brenner 199; acobyoa 1971). Bloch et.al (1888)
Gecenbed tee posses inthis ear 1) defenses may become struc
fed in respoote toa chronie mood disturbance; 2} malsdaptve de
enses may sctually lead to depression, nd 8) the mood disorder and
defenses may each be related fo a thitd ctr, such a underlying low
teifeneem, For mots theoreticians, the defenses ip depressed patients
te iniallytggered to contend with inolerably angry Eatasis or with
analy fow self-esteem bye aca only revulin an exacerbation of de
presion, Thus, anger projected outa, accoring to Abraham (1911,
Ends up being directed toward he self whereas fforstoidealize che se
trorhers to cope wth low seextem eventually lead only o father di
ppoistencand demaluation Jacobson 197). Other defenses mentioneé
‘pecially by psychoanalytic thors as mobilized to cope with inoles
Hesnger and sadness incade den pase aggresion, reaction forma
tion. and idenafcation with the aggressor
Toa more astern study by Bloch etal. (1999, the defense mech
nismsemployed by patents with dpthymaic disorder were compared with
those of patients wath panic disorder, by uring the Defense Meckarsirn
Rating Seale (DMS) (Perry 190). The sale whieh contains criteria for
operationalized asessent forte presence or absence ofeach defense,
Sacored by ue ofa pychodynanie interview Two defenses, denial and
‘epresson, were found i be uted frequendy by both pauents wth panic
Alsorder and patients with dpsthymia. Compared with pane disorder pu
‘iets, dose wth dems were found to employ higher levels of eval
tin, pase aggression, prnjection, ypackondiiasis acting ot and pro-
{ecivesdentifetion. En the formation by Bloch ec al. (188) from die
tists depression could occur throws directing anger toward the sel
tesprestng anger pasively(pasive aggression), distorting perceptions of
‘elfand other (devaluation, projection). lnvingretaition from others
{Geing out, passive aggzesion), or asking foe and thea rejecting help (re
lated tothe DMRS formolaton fer hypochondriass)2 Psychodynamic Treatmenc af Depression
In invidlpatents, the clnician shoul he alert othe characterise