Acetaminophen overdoses, peak plasma concentrations are usually achieved within 4

hours. The half-life of acetaminophen is approximately 2 to 3 hours after

Paracetamol, Redutemp, Ridenol, Silapap, Tapanol, Tempra, Tylenol, Uni- therapeutic doses, yet can be increased to more than 4 hours in patients with
Ace hepatic injury.
Classification
Adverse Reactions/Side Effects
Therapeutic: antipyretics, nonopioid analgesics GI: HEPATIC FAILURE, HEPATOTOXICITY(OVERDOSE). GU: renal failure
Indications (high doses/chronic use). Hemat: neutropenia, pancytopenia,
leukopenia. Derm: rash, urticaria.
Mild pain. Fever.
Nursing Responsibilities
Contraindications
 Assess pain and other variables (range of motion, muscle strength) to
 caloric undernutrition document whether this drug is successful in helping manage the
 acute liver failure patient's pain and decreasing impairments.
 liver problems
 severe renal impairment
 Monitor signs of leukopenia and neutropenia (fever, sore throat, signs
 a condition where the body is unable to maintain adequate blood flow
called shock of infection) or unusual weakness, fatigue, and excessive bleeding that
 acetaminophen overdose might be due to anemia or other blood dyscrasias. Report these signs
 acute inflammation of the liver due to hepatitis C virus to the physician.
Action
Inhibits the synthesis of prostaglandins that may serve as mediators of pain  Implement appropriate manual therapy techniques, physical agents,
and fever, primarily in the CNS. Has no significant anti-inflammatory and therapeutic exercises to reduce pain and decrease the need for
properties or GI toxicity. Therapeutic Effects: Analgesia. Antipyresis.
acetaminophen and other analgesics.
Pharmacokinetics
 Help patient explore other nonpharmacologic methods to reduce
Upon ingestion, acetaminophen is rapidly absorbed from the gastrointestinal chronic pain, such as relaxation techniques, exercise, counseling, and
(GI) tract and quickly distributed throughout the body. Peak plasma
concentrations are achieved within 30 to 60 minutes; food may delay time to so forth.
peak concentration, but the extent of absorption is not affected. With
 Advise patient to reduce alcohol intake because alcohol increases the
risk of liver toxicity.