2/24/2021 Summary - Epigenetic implication in coronavirus infection and therapy (1)
correo: jduartez@unal.edu.co
It has been demonstrated that viruses such coronaviruses
typically cannot hack the host genome but can alter the
host epigenome. They antagonize the immune system In viral infection
virus-fighting mechanism to promote conditions to
facilitate viral infection.
Specific methilation induces suppressiong of the
production of antigen presentation
Coronavirus family, influenza viruses, hepatitis C
virus and adenoviruses alter the holistic
Type I interferon responses are downregulated
functions of the immune system
Promote a pro-virus state
Drugs that can alter its expression may be beneficial in
Expression of ACE2 is regulated by methylation
Covid-19
Inflammation control of some epigenetic drugs
used in the treatment of cancer may be beneficial
Prevent multisystemic failure and reduce mortality
to control the high amounts of pro inflammatory
cytokines released during covid-9 severe cases.
References
https://whimsical.com/summary-epigenetic-implication-in-coronavirus-infection-and-ther-Xg1W39tFkXyjGLxj8w7VmY
Hecho por: Juan Felipe Duarte
Zambrano
CC. 1010077553
Acetylation is made by enzymes like histone
acetyltransferase which transfer an acetyl functional
group to the histones, this is related with a more relaxed
Epigenetics is an area of science which studies how
structure of chromatin that means an increase in levels of
changes in the chromatin structure can modify and
gene transcription. Deacetylation is made by histone
influence heritage and the expression of specific
deacetylase and removes the acetyl groups from histones
Epigenetics phenotypes. These modifications keep intact the
decreasing the level of gene transcription.
nucleotide chain in DNA. The main mechanism for
Histone methylation and regulation of gene expression
chromatin regulations involves both, acetylation, and
depends on which histone amino acids the methyl groups
methylation of the nucleosome histones.
are transferred to. So it can increase ore decrease gene
Epigenetic implication in coronavirus expression.
infection and therapy (1)
Virus infections have more chances to trigger a negative
Aging promotes modifications of the epigenome,
immune response by epigenetics mechanism that are per
compromising appropriate immune responses se affected in elderly population.
Interfere with antigen presentation and interferon
MERS-cov and SARS-cov
responses
1. Atlante S, Mongelli A, Barbi V, Martelli F,
Farsetti A, Gaetano C. The epigenetic implication
in coronavirus infection and therapy. Clin
Epigenetics [Internet]. 2020;12(1):1–12. Available
from: https://doi.org/10.1186/s13148-020-
00946-x
1/1