Update on SARS-CoV2 Variant

Omicron
Pompini Agustina Sitompul
Prof. Dr. Sulianti Saroso Infectious Disease Hospital
Jakarta 2021
 Omicron Variant

• 22 December 2021, the Omicron variant had been identified in

110 countries across all six WHO Regions

• There is consistent evidence that Omicron has a substantial

growth advantage over Delta. It is spreading significantly faster
than the Delta variant in countries with documented community
transmission, with a doubling time of 2-3 days

WHO,
 SARS-CoV-2 Mutation

WHO,
 Omicron Variant

• 26 November 2021  WHO designated the variant B.1.1.529 a

variant of concern (VOC) following advice from the WHO’s
Technical Advisory Group on Virus Evolution
• The variant has been given the name Omicron. Omicron is a highly
divergent variant with a high number of mutations, including 26-32
mutations in the spike protein, some of which may be associated
with humoral immune escape potential and higher transmissibility
WHO,
 Viral shedding SARS-CoV2

For survivors:
the median duration of viral shedding was 20·0 days (17·0–24·0) from
illness onset, but the virus was continuously detectable until death in
nonsurvivors
The shortest observed duration of viral shedding among survivors was 8
days, whereas the longest was 37 days.
Non survivors:
The median duration of viral shedding was 22·0 days (18·0–24·0)
The median duration of viral shedding was 19·0 days (17·0–22·0) in patients
with severe disease status and 24·0 days (22·0–30·0) in patients with critical
disease status.
WHO,
 Temporal Patterns of Viral Shedding

He X, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19

Nature MEDICINE | VOL 26 | MAY 2020 | 672–675
 Manifestasi klinis kasus Covid 19

WHO,
Manifestasi kasus di China
Survelians
kasus di
Eropa
23.343
Survelians
kasus di
Eropa
23.343
Kasus awal di Prov Gauteng, Afsel
WHO,
MANIFESTASI KLINIS (KEBUTUHAN OKSIGEN) KASUS AWAL OMICRON DI AFSEL

MA

WHO,
STATUS VAKSINASI KASUS AWAL OMICRON DI AFSEL

SARS-CoV-2 Mutation s

WHO,
 Omicron Variant

WHO,
 Omicron Variant

• In the European Region, Omicron has been confirmed as the dominant variant
in the United Kingdom (UK) with 71.5% of cases for which the S gene status of
COVID-19 cases was known to have SGTF in specimens collected between 18
and 19 December2021
• Omicron is expected to replace Delta and become the dominant variant in a
number of other countries
• In the United States of America, Omicron became the dominant variant the week
ending 18 December, accounting for approximately 73% of cases. A 1.1x
decrease in weekly cases (823 415 vs 725 750) as of 19 December was
reported. Data from 15-21 December has shown a 13% weekly increase,
suggesting an impact of Omicron on case incidence
WHO,
 Omicron Variant

WHO,
 Omicron

WHO,
 Omicron Variant

• Sampai saat ini ditemukan 68 kasus konfirm Omicron

• RSPI Sulianti saat ini melakukan isolasi kasus probable dan
konfirm Omicron tanpa gejala, gejala ringan dan sudah vaksin 2
dosis
• Tatalaksana: isolasi, multivitamin, dukungan psikologis,
rehabilitasi medik

WHO,
 Patient admission flow

Travellers quarantine officers refer patient confirmed COVID-19

Assess the clinical conditions using the mobile screening method

Short duration in Emergency Room or directly send to ward

to minimize contact with other patient and prevent spreading the infection

Immediately place the patients according to the clinical setting to a separate

isolation from patients who are not travellers
 Management

Isolation

Monitoring clinical condition

Multivitamin, comorbid control

Severe  steroid; anti IL 6

 SARS-CoV-2 Variants

• Mutations  normally happen in viruses

• Variations are still investigated in research and
new findings continue to grow  continue
making prevention efforts to reduce transmission
• Perform health promotion and safety, 3 T and
boost immunity
• Health promotion and safety : stay away from
crowds, keep your distance, wash your hands,
wear masks, limit mobility
• 3T : Testing, Tracing, Treatment
• Vaccine

WHO, EPI-Win, infodemic. An update on SARS-CoV-2 virus mutations & variants. WHO EPI-Win Update, Jan 25 2021 [Accessed April 8 2021]. Available from:
https://www.who.int/docs/default-source/coronaviruse/risk-comms-updates/update47-sars-cov-2-variants.pdf?sfvrsn=f2180835_4
Thank You 