SY12703 Genetics

Faculty of Science and Natural Resources

Universiti Malaysia Sabah

Practical 7 – Quantification of Genetic Linkages

Question 1

In a given organism, two pairs of contrasting genes are under investigation: A vs. a and B vs.
b. An F1 individual resulting from a cross between two homozygous strains was testcrossed,
and the following testcross progeny were recovered:

Phenotype Number of progeny

A B 621

A b 87

a B 92

a b 610

a) Are these two genes linked or independent?

b) If linked, what is the amount of recombination that has occurred between them?

Mock data

Females heterozygous for the recessive second chromosome mutations pn, px and sp are
mated to a male heterozygous for all three mutations. The offspring are as follows:

px sp cn 1410 + sp cn 8

px sp + 3498 + sp + 0

px + cn 1 + + cn 3483

px + + 11 +++ 1489

a) What is the genotype of the females that give rise to these progenies?
b) Determine the distances among the three genes.