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  • Colorectal Cancer Incidence Time Trends in GRELL Countries L Neamtiu, C Martos, N Dimitrova, F Giusti, G Randi, T Dyba, R Carvalho, M Flego, M Bettio

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    Raluca-Maria Sălcudean
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    Colorectal cancer incidence rates were analyzed from 29 cancer registries in Italy, Portugal, Spain, and Switzerland between 1973-2013. The results showed: 1) Incidence rates generally increased over time for males in Portugal, most Spanish regions, and several Italian regions, while decreasing in two Italian regions. 2) Incidence rates increased over time for females in most Spanish and Italian regions, but decreased in Tuscany and Geneva. 3) Detailed time trend analysis found increases starting in the late 1980s for males in two Spanish regions and several Italian regions, followed by decreases after 2006 in some Italian and Swiss regions. Increases were also seen for females in one Spanish and Italian region after 2007,

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    Colorectal cancer incidence rates were analyzed from 29 cancer registries in Italy, Portugal, Spain, and Switzerland between 1973-2013. The results showed: 1) Incidence rates generally increased over time for males in Portugal, most Spanish regions, and several Italian regions, while decreasing in two Italian regions. 2) Incidence rates increased over time for females in most Spanish and Italian regions, but decreased in Tuscany and Geneva. 3) Detailed time trend analysis found increases starting in the late 1980s for males in two Spanish regions and several Italian regions, followed by decreases after 2006 in some Italian and Swiss regions. Increases were also seen for females in one Spanish and Italian region after 2007,

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    13 views2 pages

    Colorectal Cancer Incidence Time Trends in GRELL Countries L Neamtiu, C Martos, N Dimitrova, F Giusti, G Randi, T Dyba, R Carvalho, M Flego, M Bettio

    Uploaded by

    Raluca-Maria Sălcudean
    Colorectal cancer incidence rates were analyzed from 29 cancer registries in Italy, Portugal, Spain, and Switzerland between 1973-2013. The results showed: 1) Incidence rates generally increased over time for males in Portugal, most Spanish regions, and several Italian regions, while decreasing in two Italian regions. 2) Incidence rates increased over time for females in most Spanish and Italian regions, but decreased in Tuscany and Geneva. 3) Detailed time trend analysis found increases starting in the late 1980s for males in two Spanish regions and several Italian regions, followed by decreases after 2006 in some Italian and Swiss regions. Increases were also seen for females in one Spanish and Italian region after 2007,

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    © All Rights Reserved
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    of 2

    Colorectal cancer incidence time trends in GRELL countries

    L Neamtiu, C Martos, N Dimitrova, F Giusti, G Randi, T Dyba, R Carvalho, M Flego, M Bettio

    Background

    Colorectal cancer (CRC) is the third most frequent cancer in Europe and increasing trends
    have been observed.

    The study objective is to explore time trends and geographical variations for CRC in GRELL
    countries.

    Methods

    CRC cases (ICD-O-3: C18-C20) were included in the analysis with the exclusion of
    morphology codes 9050-9055, 9140, 9590-9992.

    Age standardised incidence rates (ASR) were extracted from the European Cancer
    Information System (ECIS) web application. Cancer registries (CR) from GRELL countries
    covering until 2013 at least 15 years of incidence were included in the time-trend analysis.
    The annual percent change (APC), the annual average percent change (AAPC) and the
    corresponding confidence intervals (CIs) were calculated using the Joinpoint Trend Analysis
    Software.

    Results

    A total of 331510 cases from 29 CRs from Italy (17), Portugal (1), Spain (8) and Switzerland
    (3) were considered.

    AAPC for males showed a significant increase in Portugal (2.5%[0.5-4.5]), in the Spanish CRs
    (range 1.3[0.6-2.1] to 3.4[1.8-5.0]) except in Girona, and in 7 Italian CRs (0.7[0.4-1.1] to
    2.6[1.9-3.3]). Incidence decreased in 2 Italian CRs.

    AAPC for females increased in Spain (from 0.6[0.1 – 1.0] to 2.4[1.9 – 3.1]), except for
    Baleares and Girona, and in Italy (0.4[0.1-0.7] to 2.1[1.0-3.1]) except for Tuscany. In Tuscany
    and Geneva incidence decreased.

    APC analysis showed increase for males in 2 Spanish CRs, starting late 80s'. An increase in 7
    Italian CRs starting in mid80s' was followed by a decrease starting in 2006. A significant
    decrease was reported in 2 Italian CRs since 2006, and in 1 Swiss CR since 1973.

    For females an increasing trend in 1 Spanish CR since 2007 and 1 Italian CR since 2001 and a
    decrease in 3 Italian CRs were reported.

    Conclusions
    Geographical and time-trend variations in CRC incidence have been identified among GRELL
    countries, likely reflecting differences in the prevalence of risk factors and cancer control
    activities implemented across regions.

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